A biocompatible chitosan-based fluorescent polymer for efficient H2O2 detection in living cells and water samples

Sun, Hui; Xu, Qingyu; Ren, Mingguang; Kong, Fangong

doi:10.1016/j.ijbiomac.2023.128760

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…It is an analyte used in food [13], agricultural [14], pharmaceutical [15], clinical [16], industrial and environmental analyses [17,18]. Techniques for detecting H 2 O 2 include colorimetry [19,20], spectrometry [21], chemiluminescence [22,23], titrimetry [24], spectrophotometry [25], fluorimetry [26][27][28][29][30][31][32], the use of fiberoptic devices [33] and chromatography [34], but most of these are time-consuming, use expensive reagents and suffer with interference from various species. As such, the use of electrochemical methods such as voltammetry and amperometry presents advantages, such as low detection limits and a rapid response time [35][36][37][38][39][40][41][42][43][44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Low-Cost Carbon Paste Cu(II)-Exchanged Zeolite Amperometric Sensor for Hydrogen Peroxide Detection

Gligor,

Maicaneanu,

Varodi

2024

Chemosensors

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The aim of this work was to explore the possibility of using a Cu-exchanged zeolitic volcanic tuff (which is natural and easy to prepare and apply) for the preparation of a new low-cost carbon paste amperometric sensor for H2O2 detection. The properties of the zeolitic volcanic tuff were determined using chemical analysis, energy-dispersive X-ray spectroscopy, the specific surface area, electron microscopy, X-ray diffraction spectroscopy, and Fourier-transform infrared spectroscopy. The sensor was successfully built and operates at pH 7, at an applied potential of −150 mV Ag/AgCl/KClsat, presenting a sensitivity of 0.87 mA M−1, a detection limit of 10 µM and a linear domain up to 30 mM H2O2. These good electroanalytic parameters for H2O2 detection (a low detection limit and high sensitivity) support the possibility of using these sensors for the detection of many analytes in environmental, food and medical applications.

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Section: Introductionmentioning

confidence: 99%

Low-Cost Carbon Paste Cu(II)-Exchanged Zeolite Amperometric Sensor for Hydrogen Peroxide Detection

Gligor,

Maicaneanu,

Varodi

2024

Chemosensors

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AI‐Assisted Plasmonic Enhanced Colorimetric Fluidic Device for Hydrogen Peroxide Detection from Cancer Cells

del Real Mata,

Yedire,

Jalali

et al. 2024

Adv Materials Technologies

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Hydrogen peroxide (H2O2) is an essential molecule to various physiological processes and is commonly used for the detection and monitoring of glucose and cell viability. Furthermore, it is identified as a signal of oncogenic growth due to its widespread presence within the cancer cell environment. However, the low concentrations of H2O2 released by cancer cells' metabolism challenge current detection methods' capabilities and their practicality for translation to clinical applications. Colorimetric assays with simple readouts are a promising solution, provided that their sensitivity and rapidity in detecting H2O2 improve. Here, a plasmonic enhanced nanopatterned platform is proposed coupled with an Amplex Red assay to monitor the color change of H2O2 released from cancer cells. The nanopatterned platform embedded into a multiplexed microfluidic device enhances the kinetics of the reaction ≈7 times. This approach has reached a limit of detection of 1 pm when tested in breast (MCF‐7) and prostate (PC‐3) cancer media. The collected color images are processed and analyzed by a machine learning algorithm that categorizes them into “high” or “low‐to‐no” concentrations of H2O2 with 91% accuracy. This study is a step toward developing a device for highly sensitive H2O2 detection that is easily adaptable, user‐friendly, portable, and automated.

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A biocompatible chitosan-based fluorescent polymer for efficient H2O2 detection in living cells and water samples

Cited by 2 publications

References 49 publications

Low-Cost Carbon Paste Cu(II)-Exchanged Zeolite Amperometric Sensor for Hydrogen Peroxide Detection

Low-Cost Carbon Paste Cu(II)-Exchanged Zeolite Amperometric Sensor for Hydrogen Peroxide Detection

AI‐Assisted Plasmonic Enhanced Colorimetric Fluidic Device for Hydrogen Peroxide Detection from Cancer Cells

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