A biochemical study on the hypotensive effect of berberine in rats

Chun, Ye; Yip, T.T.; Lau, K.L.; Kong, Yao; Sankawa, Ushio

doi:10.1016/0306-3623(79)90085-5

Cited by 52 publications

(28 citation statements)

References 9 publications

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“…Previous studies have shown that berberine and its derivatives have antihypertensive activities [3][4][5][6]. In this study, consistent with previous reports, PTB-6 was an effective hypotensive agent in conscious SHR and WKY rats, and this effect was dose dependent.…”

Section: Discussionsupporting

confidence: 82%

“…A previous study has shown that berberine-induced hypotension may arise from ·-adrenoceptor blockade, rather than from direct relaxation of vascular smooth muscle [5]. However, Chun et al [4] have demonstrated that berberine can lower blood pressure, dilate blood vessels and decrease heart rate through the inhibition of acetylcholinesterase. The mechanisms underlying the cardiovascular effects of berberine are therefore not fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have found that berberine sulfate, a natural plant alkaloid isolated from Coptis chinensis, has antimicrobial and cardiovascular activities, including effects on arrhythmia, hypertension and hemodynamics [1][2][3][4][5][6][7][8]. It has been shown that intravenous infusion of berberine sulfate to rats can lower blood pressure in a dose-dependent manner [4]. With increasing doses, it may dilate peripheral blood vessels, and decrease cardiac contractility [6].…”

Section: Introductionmentioning

confidence: 99%

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The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats

et al. 1999

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Berberine is a natural isoquinoline alkaloid found in plants of the Ranunculaceae and Berberidaceae families. Extracts from berberine-containing plants have been used as traditional Chinese folk remedies for centuries. The antihypertensive effects of the berberine derivative 6-protoberberine (PTB-6) were studied in spontaneously hypertensive rats (SHRs). In conscious SHRs, PTB-6 lowered the systolic blood pressure in a dose-dependent manner (6-PTB: 5 mg/kg, –31.1 ± 1.6 mm Hg; 10 mg/kg, –42.4 ± 3.1 mm Hg). Cardiac output using the thermodilution method was reduced in PTB-6-treated anesthetized SHRs with a tendency to decrease in heart rate. Injection of PTB-6 into the intracerebral ventricles of SHRs lowered the systolic arterial blood pressure and heart rate. The berberine derivative PTB-6 is an effective antihypertensive agent. The mechanism of the antihypertensive effect of PTB-6 is probably through a central sympatholytic effect.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats

et al. 1999

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“…In traditional medicine, barberry has been used for the treatment of various heart diseases such as hypertension and arrhythmia (DerMaderosian, 2001;. Several pharmacological studies have indicated the cardiovascular effects of barberry and berberine, its famous alkaloid constituent, such as preventing ischemia-induced ventricular tachyarrhythmia, improving cardiac contractility and lowering peripheral vascular resistance, and blood pressure (Chun et al, 1979;Marin-Neto et al, 1988). A study demonstrated that the administration of the barberry extract, the fruit of B. vulgari (0.05-1 mg/100 g body weight), significantly decreased the systemic arterial blood pressure and the heart rate dose dependently in rats .…”

Section: Introductionmentioning

confidence: 99%

The promising effect of barberry (Zereshk) extract against experimental pulmonary microvascular remodeling and hypertension: A comparison with sildenafil

Mahdavi

Joukar

Najafipour

et al. 2015

Pharmaceutical Biology

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Context: Despite the beneficial effects of barberry (Berberis integerrima Berberidaceae) on decreasing systemic hypertension, its influence has not been investigated on pulmonary hypertension. Objective: The objective of this study is to examine the effect of barberry fruit, on monocrotaline-induced pulmonary hypertension. Materials and methods: Nine groups were arranged as follows: the control group, the monocrotaline (M) group, the barberry groups with doses of 50, 100, and 200 (mg/kg), the M plus barberry groups, and the M plus sildenafil group. Two weeks after a single injection of monocrotaline (60 mg/kg, s.c.), barberry water extracts or sildenafil (30 mg/kg/d) were gavaged daily for 2 weeks. At the end of the 4th week, hemodynamic, biochemical, and histopathological parameters were assessed. Results: In comparison with the M group, barberry (200 mg/kg) or sildenafil significantly reduced the right ventricular systolic pressure (RVSP) (22.95 ± 1.78 mm Hg and 30.71 ± 1.64 mm Hg, versus 41.28 ± 1.5 mm Hg), right ventricular hypertrophy (RVH) (0.39 ± 0.03 and 0.42 ± 0.02, versus 0.57 ± 0.02), and the medial wall thickness (MWT) (4.56 ± 0.15 mm and 5.97 ± 0.19 mm, versus 7.02 ± 0.43 mm). Barberry or sildenafil had no significant effect on the plasma level of endothelin-1, glutathione peroxidase, and the malondialdehide of lung. Conclusion: 200 mg/kg of barberry has an improving effect on the monocrotaline-induced pulmonary hypertension. This effect was stronger than that of the sildenafil's and may have been mediated through mechanisms other than the modulation of the endothelin-1 or redox system.

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“…25,26 The mechanism for berberine's antiarrhythmic effect is not clear, but an animal study indicated it may be due to suppression of delayed after-depolarization in the ventricular muscle. …”

mentioning

confidence: 99%

Therapeutic Aspects of Goldenseal

Asmi¹,

Lakshmi²

2013

Int. Res. J. Pharm.

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Goldenseal, commonly known as yellow puccoon has wide therapeutic activity. The bioactive components present are isoquinoline alkaloids, hydrastine, berberine and canadine. Berberine is used to treat heart failure also have sedative actions, anti secretory, anti parasitic, anticancerous actions. Hence an attempt was taken to review the pharmacological actions of Goldenseal with respect to its role in dental practice.

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A biochemical study on the hypotensive effect of berberine in rats

Cited by 52 publications

References 9 publications

The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats

The Antihypertensive Effect of the Berberine Derivative 6-Protoberberine in Spontaneously Hypertensive Rats

The promising effect of barberry (Zereshk) extract against experimental pulmonary microvascular remodeling and hypertension: A comparison with sildenafil

Therapeutic Aspects of Goldenseal

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