A biochemical study of the origin of arginine aminopeptidases in human gingival fluid

Mäkinen, Kauko K.; Hyyppä, T

doi:10.1016/0003-9969(75)90213-7

Cited by 13 publications

(2 citation statements)

References 21 publications

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“…The oral fluid of healthy persons is known to exhibit a very low Oactivated aminopeptidase activity. The source of these enzymes seems to be the gingival fluid, where their activity increases with the severity of gingival inflammation (Makinen & Hyyppa 1975). The enzyme activity has also been found to be connected with the increase of leucocytes and mononuclear phagocytes (Knuuttila et al 1978).…”

Section: Discussionmentioning

confidence: 99%

Studies on immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis

Hyyppä

1981

J Clinic Periodontology

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To study the salivary response in asthma and periodontitis, calcium and phosphorus concentrations were determined from parotid and whole saliva. The IgE and histamine concentrations and the activities of lysozyme and arginine aminopeptidases were assayed from whole saliva. The values were compared with those obtained from matched healthy controls (n = 20 in each group). In whole saliva the phosphorus concentrations were elevated in the asthma group and the calcium concentrations in the periodontitis group. Regarding parotid saliva no significant differences between the groups were observed. The results indicate that in patients with asthma the IgE concentrations in whole saliva were elevated, while in patients with periodontitis and in healthy controls no detectable values were obtained. Both histamine and lysozyme concentrations seemed to increase in the asthma and periodontitis groups. A slight increase was also observed in the arginine aminopeptidase activities in the saliva of patients with asthma and patients with periodontitis.

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Section: Discussionmentioning

confidence: 99%

Studies on immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis

Hyyppä

1981

J Clinic Periodontology

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“…soni 1983). With the exception of aminopep-At least 5 more enzymes of this class have tidase (Makinen & Hyppa 1975), all pro-been characterized; namely., cathepsins H, teinases studied in gingival fluid belong to L, N, S and T, of which cathepsin L exhibits the endopeptidases. In this group of proteo-the highest proteolytic activity and collagenlytic enzymes the aspartic proteinase -ca-olysis of insoluble collagen at pH 3.5 thepsin D (Tzamouraniset al 1977)., neutral (Kirschke et al 1982).…”

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confidence: 99%

Detection of cathepsin L‐like proteinase and cathepsin D in gingival fluid

Lah

Skallrič

Babnik

et al. 1986

J of Periodontal Research

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Intracellular proteinases play an important role in normal and pathological degradative processes. The contribution of cysteine proteinases in connective tissue breakdown is known, but their activity in the inflammatory process of periodontal disease received only limited attention. Gingival fluid was collected from eight female patients with different degrees of periodontal disease as indicated by pocket depth. Proteolytic activity of cathepsins, D and L was measured using hemoglobin as substrate. Evidence that cathepsin L‐like proteinase contributed significantly to acid proteolytic activity in gingival fluid was found. In addition, proteolytic activity at pH 3.5 and cathepsin L‐like activity in gingival fluid were positively correlated with the degree of periodontal disease as measured by the pocket depth at the site of fluid collection. Cathepsin D in crevicular fluid was also determined immunologically. These results may contribute to a better understanding of the etiopathology of periodontal disease.

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References

Mäkinen

1978

Biochemical Principles of the Use of Xylitol in Medicine and Nutrition With Special Consideration of Dental Aspects

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A biochemical study of the origin of arginine aminopeptidases in human gingival fluid

Cited by 13 publications

References 21 publications

Studies on immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis

Studies on immunologic and inflammatory factors in saliva in patients with asthma and in patients with periodontitis

Detection of cathepsin L‐like proteinase and cathepsin D in gingival fluid

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