A Biochemical Study of Cerebral Tissue, and of the Changes in Cerebral Ædema

Stewart-Wallace, A. M.

doi:10.1093/brain/62.4.426

Cited by 73 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, the corpus cal losum has a higher water content (Stewart-Wallace, 1939), and thus a higher A of 0.94 ml/g, than the white matter of the centrum semi-ovale. The water contents of the thalamus and caudate nucleus are lower than that of cortical gray matter (Randall, 1938;Stewart-Wallace, 1939). Thus, their computed partition coefficients are 0.94 mllg and 1.01 ml/g, respectively, which are lower than that of cortical gray matter.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique

Herscovitch

Raichle

1983

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Summary:The equilibrium C 1502 inhalation method for measuring cerebral blood flow with positron emission to mography (PET) is based on a one-compartment model for which it is assumed that the local flow and partition coefficient are uniform in the tissue region in which flow is to be determined. However, because of the limited spa tial resolution of PET, a region of interest will contain a mixture of gray and white matter. We used a computer simulation to examine the effect of this heterogeneity on flow measurement in both normal and pathological states. With gray and white matter flows of 0.80 and 0.20 mll min/g, respectively, flow is underestimated by a max imum of 20% in a region that is 30% gray. Errors occur not only because of flow heterogeneity, but also because of heterogeneity of partition coefficient and the sensiPositron emission tomography (PET) makes pos sible the in vivo, regional quantitation of radio tracers labeled with positron-emitting radionu elides. By using appropriate mathematical models which describe the behavior of specific radio tracers, cerebral blood flow (CBF) can be deter mined from measurements of brain and blood ra dioactivity.Several methods have been proposed for mea suring regional CBF (rCBF) with PET using ox ygen-15-labeled water as an inert tracer (Subra manyam et al., 1978;Raichle et al., 1981;Huang et al., 1982). These techniques differ with respect to the mode of radiotracer administration and the im-

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique

Herscovitch

Raichle

1983

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

show abstract

“…Cerebral cortex water content was determined using a previously described wet-to-dry weight ratio technique [40,41]. Briefly, oven dried eppendorf's were weighed, then 50 mm 2 wet frontal cortex samples placed into individual eppendorf's and reweighed; all samples weighed within 0.1 mg of each other.…”

Section: Brain Watermentioning

confidence: 99%

Role of aquaporin-4 in the development of brain oedema in liver failure

Wright

Soper²,

Brooks

et al. 2010

Journal of Hepatology

View full text Add to dashboard Cite

“…26 The water content of brain tissue was measured as an indicator of brain edema. Following induction of a state of deep anesthesia, the left and right hemispheres were removed from the rats and samples of the frontal, parietal, and occipital lobes were obtained for the measurement of AQP4.…”

Section: Measurement Of Brain Edemamentioning

confidence: 99%

Regulation of aquaporin-4 in a traumatic brain injury model in rats

Sun¹,

Honey²,

Berk³

et al. 2003

Journal of Neurosurgery

117

View full text Add to dashboard Cite

show abstract

A Biochemical Study of Cerebral Tissue, and of the Changes in Cerebral Ædema

Cited by 73 publications

References 0 publications

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique

Role of aquaporin-4 in the development of brain oedema in liver failure

Regulation of aquaporin-4 in a traumatic brain injury model in rats

Contact Info

Product

Resources

About

A Biochemical Study of Cerebral Tissue, and of the Changes in Cerebral Ædema

Cited by 73 publications

References 0 publications

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C15O2Inhalation Technique

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C15O2Inhalation Technique

Role of aquaporin-4 in the development of brain oedema in liver failure

Regulation of aquaporin-4 in a traumatic brain injury model in rats

Contact Info

Product

Resources

About

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique

Effect of Tissue Heterogeneity on the Measurement of Cerebral Blood Flow with the Equilibrium C¹⁵O₂Inhalation Technique