A biochemical perspective on the fate of virgin olive oil phenolic compounds
            <i>in vivo</i>

Costa, Vânia; Lopes, Margarida; Paiva‐Martins, Fátima

doi:10.1080/10408398.2022.2116558

Cited by 6 publications

(5 citation statements)

References 205 publications

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“…Mal d 3, a lipid transfer protein (LTP), although not considered a major allergic component, has been associated with an elevated risk of severe allergic reactions to apple, particularly in southern European regions such as Spain. 37,38 Conversely, in regions abundant with birch trees, sensitization to Mal d 3 may not necessarily indicate severe reactions to apple but rather to peach or nuts. 19,39,40 According to a study conducted by Deng et al, 41 LTPs (Pru p 3, Mal d 3, etc) have been identified as the primary food allergens associated with mugwort pollen-related food allergy in China due to their homology with Art v 3.…”

Section: Discussionmentioning

confidence: 99%

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Wang,

Chen,

Ding

et al. 2023

JAA

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To investigate the major allergen components associated with birch pollen allergy in northern China and elucidate clinical relevance to pollen food allergy syndrome (PFAS). Methods: Fifty-eight patients were recruited for a cross-sectional study and categorized into two groups: PFAS group and non-PFAS group, as well as apple allergy group and non-apple allergy group. The sIgE levels of birch pollen and its components, namely Bet v 1, Bet v 2, Bet v 4, and Bet v 6, were analyzed. Results: Among 58 participants, 44 individuals (75.9%) reported PFAS. 32 out of 44 (72.7%) participants reported apple allergy. Bet v 1 exhibited the highest sensitization rate at 82.8%, followed by Bet v 2 (29.3%) and Bet v 6 (1.7%). The combined sensitization rate for Bet v 1 and/or Bet v 2 was 93.1%. A total of 77.6% of the subjects demonstrated sensitization to single component, while 19.0% exhibited sensitization to two components. The sIgE levels of birch pollen and Bet v 1 were significantly elevated in PFAS group compared to non-PFAS group (p=0.001, p<0.001, respectively), as well as in apple-allergic and non-apple-allergic group (p<0.001, p<0.001, respectively). The optimal cut-off values for birch pollen and Bet v 1 sIgE were determined to be 7.09 kUA/L (with a sensitivity of 84.1% and specificity of 78.6%) and 5.11 kUA/L (with a sensitivity of 75.0% and specificity of 85.7%) when diagnosing PFAS. In terms of apple allergy, the optimal cut-off value were 9.40 kUA/L (with a sensitivity of 81.3% and specificity of 76.9%) and 6.53 kUA/L (with a sensitivity of 84.4% and specificity of 84.6%), respectively. Conclusion:The predominant sensitization pattern is mono-sensitization to Bet v 1, but when considering immunotherapy, Bet v 2 should also be taken into account. Bet v 1 serves as a valuable biomarker for diagnosing PFAS and apple allergy.

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Section: Discussionmentioning

confidence: 99%

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Wang,

Chen,

Ding

et al. 2023

JAA

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“…Simple phenols (hydroxytyrosol, tyrosol), polyphenols (flavonoids, apigenin, luteolin), lignans (pinoresinol, 1-acetoxypinoresinol), secoiridoids (oleuropein, glycosylated oleuropein, demethyleoleuropein, elenolic acid, ligstroside their aglycons and an isomer of the oleuropein aglycon (3,4-DHPEA-EA) and oleocanthal (p-HPEA-EA)) are present in extra virgin olive oil. Secoiridoids and lignans are the most concentrated polyphenols in extra virgin olive oil [21]. They give extra virgin olive oil several desirable properties, including preventing oxidation, extending shelf life, and imparting bitter, astringent, and pungent organoleptic characteristics.…”

Section: Polyphenolsmentioning

confidence: 99%

“…They give extra virgin olive oil several desirable properties, including preventing oxidation, extending shelf life, and imparting bitter, astringent, and pungent organoleptic characteristics. They also exert strong antioxidant activity and show preventive action against cancer and cardiovascular diseases [1][2][3]18,19,21] along with reducing the chance of neurodegenerative illnesses and maintaining human well-being [20]. Tyrosol and hydroxytyrosol (absorption rates range from 40 to 95%) are extensively metabolised and the most absorbed phenolics are from the small intestine [6].…”

Section: Polyphenolsmentioning

confidence: 99%

Extra Virgin Olive Oil Composition and its Bioactive Phenolic Compounds

Kiritsakis

2023

NTNF

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“…Esters of these alcohols with elenolic acid or its derivatives are an important subclass of phenols known as secoiridoids. While phenolic acids, phenolic alcohols and flavonoids occur in many fruits and vegetables, secoiridoids are present exclusively in plants belonging to the family Oleaceae , which includes Olea europaea L. Major examples of phenolic secoiridoids include oleuropein, oleacein and oleocanthal ( Figure 3 ) [ 30 ].…”

Section: Antioxidantsmentioning

confidence: 99%

Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications

et al. 2022

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Natural antioxidants from fruits and vegetables, meats, eggs and fish protect cells from the damage caused by free radicals. They are widely used to reduce food loss and waste, minimizing lipid oxidation, as well as for their effects on health through pharmaceutical preparations. In fact, the use of natural antioxidants is among the main efforts made to relieve the pressure on natural resources and to move towards more sustainable food and pharmaceutical systems. Alternative food waste management approaches include the valorization of by-products as a source of phenolic compounds for functional food formulations. In this review, we will deal with the chemistry of antioxidants, including their molecular structures and reaction mechanisms. The biochemical aspects will also be reviewed, including the effects of acidity and temperature on their partitioning in binary and multiphasic systems. The poor bioavailability of antioxidants remains a huge constraint for clinical applications, and we will briefly describe some delivery systems that provide for enhanced pharmacological action of antioxidants via drug targeting and increased bioavailability. The pharmacological activity of antioxidants can be improved by designing nanotechnology-based formulations, and recent nanoformulations include nanoparticles, polymeric micelles, liposomes/proliposomes, phytosomes and solid lipid nanoparticles, all showing promising outcomes in improving the efficiency and bioavailability of antioxidants. Finally, an overview of the pharmacological effects, therapeutic properties and future choice of antioxidants will be incorporated.

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A biochemical perspective on the fate of virgin olive oil phenolic compounds in vivo

Cited by 6 publications

References 205 publications

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Profiles of Birch Allergen Component Sensitization and Its Association with Pollen Food Allergy Syndrome in Northern China

Extra Virgin Olive Oil Composition and its Bioactive Phenolic Compounds

Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications

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