A Biochemical Background of Calory Restriction Therapy of Obesity: Lipid Peroxide Mobilization

Ohtsu, Eiji; Endo, Satoshi; Ohki, Akiko; Matsuzawa, Daiju

doi:10.1016/b978-0-08-023799-2.50032-0

Cited by 2 publications

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“…This has been typically shown in the obese hypertensives rather than in the obese (7). Therefore, in the present work, we examined the endogenous capacity for individual prostanoid biosynthesis in the brain-stem using hypertensive animals.…”

Section: Discussionmentioning

confidence: 99%

Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1.ALPHA., thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats.

Ohtsu

Matsuzawa

1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryEndogenous biosynthetic capacities for prostaglandin (PG)E2, thromboxane (TX)B2 (a stable degradation product of TXA2) and 6 keto-PGF1a (a stable degradation product of PGI2) in the brain stem fractions of stroke-resistant spontaneously hypertensive rats (SHRSR) and control Wistar-Kyoto rats (WKR) were determined with novel methods and presented in an original report. In comparison with WKR, it is characteristically found that TXB2 synthesis is increased in excess of threefold in the pons-medulla oblongata of SHRSR, while being decreased by 75% in the hypothalamic region of SHRSR (0.01

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Section: Discussionmentioning

confidence: 99%

Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1.ALPHA., thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats.

Ohtsu

Matsuzawa

1980

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Endogenous formation of prostanoids and the levels of long‐chain fatty acyl CoA derivatives in suspensive and adhesive cells from in vitro embryoid bodies of teratoma OTT 6050

1981

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Attachment of the cell surface to a substratum may play a critical role in initiating some cellular developmental commitments and in sustaining differentiation of cells that have already been specialized. Embryoid bodies of teratoma OTT6050 were divided, on day 10 of initial culture, into myogenic adhesive cells which were already (at day 6) characterized by endogenous prostaglandin (PG)12 formation and little-specialized suspensive cells which formed only thromboxane (TX)B2 in the same culture system. Since at day 10 both cell types reached a stationary phase in which the nature of each cell was mature enough for the analyses with mass fragmentographic technique and gas chromatography-mass spectrometry (GCMS), the total levels of predominant long-chain fatty acyl CoA (acyl CoA) derivatives could be measured comparatively as methyl esters after methanolysis. I t was found as a result of major differentiation that adhesive cells had a rather low ratio of arachidonyl CoA to stearyl CoA, although adhesive cells accumulated a larger total amount of acyl CoA derivatives than that accumulated in suspensive cells.

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A Biochemical Background of Calory Restriction Therapy of Obesity: Lipid Peroxide Mobilization

Cited by 2 publications

References 0 publications

Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1.ALPHA., thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats.

Metabolic alterations in the endogenous formation of 6 keto-prostaglandin F1.ALPHA., thromboxane B2 and prostaglandin E2 in the brain-stem of stroke-resistant spontaneously hypertensive rats.

Endogenous formation of prostanoids and the levels of long‐chain fatty acyl CoA derivatives in suspensive and adhesive cells from in vitro embryoid bodies of teratoma OTT 6050

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