A bioactive “self-fitting” shape memory polymer scaffold with potential to treat cranio-maxillo facial bone defects

Zhang, Dawei; George, Olivia J; Petersen, Keri M.; Jimenez-Vergara, Andrea Carolina; Hahn, Mariah S.; Grunlan, Melissa A.

doi:10.1016/j.actbio.2014.07.020

Cited by 176 publications

(202 citation statements)

References 69 publications

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“…Also biocompatible gels obtained from acrylic derivatives or gelatin exhibiting cells stimulation effect have been reported . However, for formation of such types of the scaffolds, almost solely the cross‐linked polymers are used …”

Section: Introductionmentioning

confidence: 99%

Scaffolds with shape memory behavior for the treatment of large bone defects

Rychter

Pamuła

Orchel³

et al. 2015

J Biomedical Materials Res

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The aim of the presented study was preparation, analysis of properties, and in vitro characterization of porous shape-memory scaffolds, designed for large bone defects treatment using minimally invasive surgery approach. Biodegradable terpolymers of l-lactide/glycolide/trimethylene carbonate (LA/GL/TMC) and l-lactide/glycolide/ε-caprolactone (LA/GL/Cap) were selected for formulation of these scaffolds. Basic parameters of shape memory behavior (i.e. recovery ratio, recovery time) and changes in morphology (SEM, average porosity) and properties (surface topography, water contact angle, compressive strength) during shape memory cycle were characterized. The scaffolds preserved good mechanical properties (compressive strength about 0.7 to 0.9 MPa) and high porosity (more than 80%) both in initial shape as well as after return from compressed shape. Then the scaffolds in temporary shape were inserted into the model defect of bone tissue at 37°C. After 12 min the defect was filled completely as a result of shape recovery process induced by body temperature. The scaffold obtained from LA/GL/TMC terpolymer was found the most prospective for the planned application thanks to its appropriate recovery time, high recovery ratio (more than 90%), and cytocompatibility in contact with human osteoblasts and chondrocytes.

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Section: Introductionmentioning

confidence: 99%

Scaffolds with shape memory behavior for the treatment of large bone defects

Rychter

Pamuła

Orchel³

et al. 2015

J Biomedical Materials Res

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“…These materials promoted adhesion, proliferation, osteogenic gene expression and extracellular matrix deposition when cultured with human osteoblasts in vitro. [57] Furthermore, composite materials incorporating hydroxyapatite are commonplace in bone tissue engineering studies, and composites of poly(D,L-lactide) and hydroxyapatite have been reported to display temperature-responsive shape-memory properties. [58] Studies employing temperature-responsive foams based on composites of polycaprolactone and hydroxyapatite showed that they were capable of controlled release of bone morphogenetic protein-2 and displayed good cytocompatibility towards rabbit bone marrow-derived stem cells in vitro.…”

Section: Research Newsmentioning

confidence: 99%

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

et al. 2016

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Shape-memory polymers (SMPs) are morphologically responsive materials with potential for a variety of biomedical applications, particularly as devices for minimally invasive surgery and the delivery of therapeutics and cells for tissue engineering. A brief introduction to SMPs is followed by a discussion of the current progress toward the development of SMP-based biomaterials for clinically relevant biomedical applications.

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“…Grunland and Hahn recently designed a thermoresponsive SMP that were able to self-fit into irregular cranio-maxillo facial bone defects and exhibited interconnected porous morphology similar to that of bone. 127 Poly(ε-caprolactone) scaffolds were softened by heating to above their melting transition temperature ( T m ∼ 55 °C) for manual compression and subsequent expansion into irregular boundaries upon release of pressure. Cooling locked the final scaffold conformation for tailored bone implants.…”

Section: Structural Dynamics Of Polymer Assembliesmentioning

confidence: 99%

Biosynthetic Polymers as Functional Materials

2016

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The synthesis of functional polymers encoded with biomolecules has been an extensive area of research for decades. As such, a diverse toolbox of polymerization techniques and bioconjugation methods has been developed. The greatest impact of this work has been in biomedicine and biotechnology, where fully synthetic and naturally derived biomolecules are used cooperatively. Despite significant improvements in biocompatible and functionally diverse polymers, our success in the field is constrained by recognized limitations in polymer architecture control, structural dynamics, and biostabilization. This Perspective discusses the current status of functional biosynthetic polymers and highlights innovative strategies reported within the past five years that have made great strides in overcoming the aforementioned barriers.

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A bioactive “self-fitting” shape memory polymer scaffold with potential to treat cranio-maxillo facial bone defects

Cited by 176 publications

References 69 publications

Scaffolds with shape memory behavior for the treatment of large bone defects

Scaffolds with shape memory behavior for the treatment of large bone defects

Responsive Biomaterials: Advances in Materials Based on Shape‐Memory Polymers

Biosynthetic Polymers as Functional Materials

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