A bioabsorbable microclip for laryngeal microsurgery: Design and evaluation

Chng, Chin Boon; Lau, David P.; Choo, J. Q.; Chui, Chee-Kong

doi:10.1016/j.actbio.2012.03.051

Cited by 39 publications

(15 citation statements)

References 32 publications

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“…In the field of minimally invasive surgery there is an exponentially growing interest in biodegradable and biocompatible polymers with shape memory behavior. Especially materials, for which the self‐expansion is induced by temperature increase, have been accepted as various implants or medical tools . The idea of application of such type of materials in regenerative medicine seems to be very interesting and indicates more appropriate way instead of that using mentioned above hydrogel matrices.…”

Section: Introductionmentioning

confidence: 99%

“…Especially materials, for which the self-expansion is induced by temperature increase, have been accepted as various implants or medical tools. 10,11 The idea of application of such type of materials in regenerative medicine seems to be very interesting and indicates more appropriate way instead of that using mentioned above hydrogel matrices. In this case, the implantation of material is possible in the highly compressed form allowing for the considerable reduction of trauma and subsequent improvement of patient comfort.…”

Section: Introductionmentioning

confidence: 99%

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Scaffolds with shape memory behavior for the treatment of large bone defects

Rychter

Pamuła

Orchel³

et al. 2015

J Biomedical Materials Res

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The aim of the presented study was preparation, analysis of properties, and in vitro characterization of porous shape-memory scaffolds, designed for large bone defects treatment using minimally invasive surgery approach. Biodegradable terpolymers of l-lactide/glycolide/trimethylene carbonate (LA/GL/TMC) and l-lactide/glycolide/ε-caprolactone (LA/GL/Cap) were selected for formulation of these scaffolds. Basic parameters of shape memory behavior (i.e. recovery ratio, recovery time) and changes in morphology (SEM, average porosity) and properties (surface topography, water contact angle, compressive strength) during shape memory cycle were characterized. The scaffolds preserved good mechanical properties (compressive strength about 0.7 to 0.9 MPa) and high porosity (more than 80%) both in initial shape as well as after return from compressed shape. Then the scaffolds in temporary shape were inserted into the model defect of bone tissue at 37°C. After 12 min the defect was filled completely as a result of shape recovery process induced by body temperature. The scaffold obtained from LA/GL/TMC terpolymer was found the most prospective for the planned application thanks to its appropriate recovery time, high recovery ratio (more than 90%), and cytocompatibility in contact with human osteoblasts and chondrocytes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Scaffolds with shape memory behavior for the treatment of large bone defects

Rychter

Pamuła

Orchel³

et al. 2015

J Biomedical Materials Res

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“…The task can be completed using our micro-clips in a few minutes regardless of the skill level of the surgeons. 5,6 The surgical clip may provide excellent healing results, and it can be easily exerted onto wound because of its extremely small size and able to withstand high vibration frequencies and shearing stresses during phonation. Magnesium-based micro-clips used in wound closure in laryngeal microsurgery involving vocal cord covers have been studied in previous works.…”

Section: Introductionmentioning

confidence: 99%

“…Magnesium-based micro-clips used in wound closure in laryngeal microsurgery involving vocal cord covers have been studied in previous works. 5,7,8 The clips would completely degrade and absorbed by the patient body within several weeks' time. The degradation of magnesium will have no influence on the properties of the connected tissue as magnesium metabolism of a living subject is dependent on the introduction of the magnesium.…”

Section: Introductionmentioning

confidence: 99%

Modeling and simulation of material degradation in biodegradable wound closure devices

et al. 2014

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Biodegradable materials have been used as wound closure materials. It is important for these materials to enhance wound healing when the wound is vulnerable, and maintain wound closure until the wound is heal. This article studies the degradation process of bioresorbable magnesium micro-clips for wound closure in voice/laryngeal microsurgery. A novel computational approach is proposed to model degradation of the biodegradable micro-clips. The degradation process that considers both material and geometry of the device as well as its deployment is modeled as an energy minimization problem that is iteratively solved using active contour and incremental finite element methods. Strain energy of the micro-clip during degradation is calculated with the stretching and bending functions in the active contour formulation. The degradation rate is computed from strain energy using a transformation formulation. By relating strain energy to material degradation, the degradation rates and geometries of the micro-clip during degradation can be represented using a simulated degradation map. Computer simulation of the degradation of the micro-clip presented in the study is validated by in vivo and in vitro experiments.

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“…Figure 8.1 shows some of the implants made of biomedical Mg alloys. Accordingly, the characteristics of modified Mg and its alloys are altered with the purpose of reducing and controlling the corrosion rates and increasing their (Erdmann et al, 2010), and microclips (c) (Chng, Lau, Choo, & Chui, 2012) made of magnesium alloys. During severe corrosive attacks, hydrogen Table 8.1 Mechanical properties of the metals that are used as biomedical and related materials (Gu et al, 2009;Yang et al, 2010;Hermawan et al, 2010, Witte et al, 2008 is produced rapidly and the OH À ion induces alkalization of the surrounding environments.…”

Section: Introductionmentioning

confidence: 99%