A binary solvent gel as drug delivery carrier

Kong, Li; Zhang, Feng; Xing, Peng; Chu, Xiaoxiao; Hao, Aiyou

doi:10.1016/j.colsurfa.2017.03.016

Cited by 16 publications

(8 citation statements)

References 34 publications

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“…Pluronic ® polymers were self-assembled into Pluronic micelles with a hydrophilic PEO segment at the corona and a hydrophobic PPO segment in the core. Studies elucidated that 5-FU would be hydrophilic [ 20 , 21 , 22 , 23 , 24 ] or hydrophobic molecules [ 25 , 26 , 27 , 28 ]. However, for drug release, the encapsulation of the drug in micelles was highly dependent on its loading location rather than the intrinsic solubility of the drug in aqueous solution.…”

Section: Resultsmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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Chemotherapy is one of the most important ways to treat cancer. At present, chemotherapy medicines are mainly administered by intravenous injection or oral administration. However, systemic medical care requires the dosage of high concentrations of drugs to defeat the malignant tumor growth. In recent years, the use of polymer composites for local and sustained drug release has become an important field of research to minimize side effects due to high-concentration chemotherapy drugs. Here, 19F-{1H} heteronuclear Overhauser enhancement spectroscopy (HOESY) was used to study the micellular environment of the F-containing chemotherapeutic drug 5-FU in Pluronic F127, Pluronic L121, and F127/L121 binary blending composites. The distribution of 5-FU in micelles is related to the PEO and PPO segment length of Pluronic polymers and the environmental temperature. The drug release tests further confirm that if 5-FU medicines were loaded in the PPO segment inside the micelles, the purpose of the prolonged drug release carrier is achieved.

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Section: Resultsmentioning

confidence: 99%

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Lin

Yeh

2021

Polymers

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“…Doxorubicin as a hydrophilic drug was dispersed in the water channels, which is beneficial to diffuse through dissolution. 29 The release profiles of HEC-GEL(DOX), GEL(DOX), and DOX in PBS were shown in Figure 4B. There was no significant difference in drug release (p > 0.05) between the HEC-GEL(DOX) and GEL(DOX) group, indicating that the release of the doxorubicin was only controlled by dissolution and corrosion of gelatin.…”

Section: Resultsmentioning

confidence: 95%

“…PEG formed water channels between gel skeletons due to its high water storage performance. Doxorubicin as a hydrophilic drug was dispersed in the water channels, which is beneficial to diffuse through dissolution …”

Section: Resultsmentioning

confidence: 99%

Doxorubicin-Loaded In Situ Gel Combined with Biocompatible Hydroxyethyl Cellulose Hemostatic Gauze for Controlled Release of Drugs and Prevention of Breast Cancer Recurrence Postsurgery

Yan

Liu

et al. 2020

ACS Biomater. Sci. Eng.

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Biodegradable hemostatic gauze used for surgical hemostasis has attracted great interest due to its excellent compliance and local anti-inflammatory and therapeutic effects when combined with drugs. Herein, we demonstrate the successful fabrication of water-soluble absorbed cellulose hemostatic material by introducing a biocompatible hydroxyethyl cellulose (HEC) hemostasis gauze into doxorubicin-loaded in situ gel (GEL(DOX)) for the prevention of breast cancer recurrence after surgical tumor resection. The present results show that HEC has a shorter metabolic period, no anaphylaxis and peripheral nerve toxicity, and possesses more advantages than oxidative regenerated cellulose hemostasis gauze, a commercially available product in market. HEC is of the physical hemostasis in mechanism, which does not induce physiological hemostasis and hemolysis. In addition, the combination of HEC with GEL(DOX) not only stops the bleeding efficiently, but also effectively reduces the proliferation of tumor with no cardiac toxic and bone marrow suppression. After treatment, the tumor inhibition rate is up to 90%, resulting in prolonged survival time to 58 days. In conclusion, HEC hemostatic gauze has a broad prospect in clinical application due to its perfect biocompatibility, and we envision that it is a new strategy for the prevention of breast cancer to implant HEC hemostatic gauze containing GEL(DOX) at the postoperative site after surgery.

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“…[9][10][11][12] As compared to the other DDSs, metal-organic frameworks (MOFs) are fascinating materials having many advantages such as, tunable structures, compositions and chemical properties enriched methods of modication and functionality. [13][14][15][16][17][18][19] Interestingly, the benecial physicochemical features of MOFs are unaffected by modication. Beside this, large surface areas and high porosity endow MOFs with high loading capacity of different type of molecules like gas and drugs.…”

Section: Introductionmentioning

confidence: 99%

Development of a pH-sensitive functionalized metal organic framework:in vitrostudy for simultaneous delivery of doxorubicin and cyclophosphamide in breast cancer

et al. 2021

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A binary solvent gel as drug delivery carrier

Cited by 16 publications

References 34 publications

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Thermosensitive Interfacial Migration of 5-FU in the Microenvironment of Pluronic Block Copolymers

Doxorubicin-Loaded In Situ Gel Combined with Biocompatible Hydroxyethyl Cellulose Hemostatic Gauze for Controlled Release of Drugs and Prevention of Breast Cancer Recurrence Postsurgery

Development of a pH-sensitive functionalized metal organic framework:in vitrostudy for simultaneous delivery of doxorubicin and cyclophosphamide in breast cancer

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