A bihemispheric autonomic model for traumatic stress effects on health and behavior

Lee, Sung W.; Gerdes, Lee; Tegeler, Catherine L.; Shaltout, Hossam A.; Tegeler, Charles H.

doi:10.3389/fpsyg.2014.00843

Cited by 30 publications

(35 citation statements)

References 51 publications

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“…For example, noninvasive photic and auditory technologies have shown promising initial results in the chronic phase of treatment [126,127]. The benefits of near-infrared light for intracellular healing have also been associated with reduced depressive severity and improved sleep quality over a 2-month period among 10 patients with persistent TBI symptoms [128].…”

Section: What Are Treatment Development Opportunities For Sleep Distumentioning

confidence: 99%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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Disturbed sleep is one of the most common complaints following traumatic brain injury (TBI) and worsens morbidity and long-term sequelae. Further, sleep and TBI share neurophysiologic underpinnings with direct relevance to recovery from TBI. As such, disturbed sleep and clinical sleep disorders represent modifiable treatment targets to improve outcomes in TBI. This paper presents key findings from a national working group on sleep and TBI, with a specific focus on the testing and development of sleep-related therapeutic interventions for mild TBI (mTBI). First, mTBI and sleep physiology are briefly reviewed. Next, essential empirical and clinical questions and knowledge gaps are addressed. Finally, actionable recommendations are offered to guide active and efficient collaboration between academic, industry, and governmental stakeholders.

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Section: What Are Treatment Development Opportunities For Sleep Distumentioning

confidence: 99%

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

et al. 2016

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“…Freely [14,15]. We cannot determine how long after BLAST an individual may experience cognitive and physiological symptoms of anxiety again, as this is highly variable per individual.…”

Section: Methodsmentioning

confidence: 99%

The Therapeutic Effect of Bilateral Alternating Stimulation Tactile Form Technology on the Stress Response

Serin¹,

Hageman

Каде

2018

JBBS

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The application of bilateral alternating stimulation in tactile (BLAST) form technology, a non-invasive, somatosensory-based method, has been shown to modulate the electrical activity of brain networks that mediate the stress response, resulting in a stress-reducing effect in individuals with high reported levels of anxiety, such as post-traumatic stress disorder (PTSD). In this study, we examined archival data from a heterogeneous group of users (n = 1109) of BLAST technology via Touchpoints, a novel BLAST-based treatment modality, all of whom had high self-reported levels of stress and anxiety. Ratings of levels of emotional stress and bodily distress on a scale of 0 (no stress/distress) to 10 (worst stress/distress of one's life) before and after the application of Touchpoints for 30 seconds were entered into an app. Results showed a statistically significant reduction in the levels of both emotional stress and bodily distress, 62.26% and 50.502%, respectively, after 30 seconds of BLAST technology was applied. This demonstrates a clear benefit of BLAST on the stress response, reducing both emotional stress and disturbing body sensations. Recent work examining EEG changes after BLAST technology is applied suggests that BLAST may reduce sympathetic activation by reducing the electrical activity of key areas of the salience network. Further work will more precisely characterize the effects of BLAST, its potential clinical uses, and the mechanisms of actions behind it's apparent stress-reducing effects.

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“…Moreover, such asymmetry is not static but dynamic and adjustable depending on the variability in exogenous conditions such as light or dark conditions (Ramirez et al 2004) or endogenous environment like type and level of sex steroids (Ramirez et al 2008;Rueda et al 2016), stress (Lee et al 2014), brain dopamine content (Banegas et al 2009 or drug treatments involving the RAS, such as ACE inhibitors (Segarra et al 2012.…”

Section: Brain Asymmetrymentioning

confidence: 99%

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

Prieto

Segarra

Martı́nez-Cañamero

et al. 2017

Endocrine Regulations

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Th e cardiovascular control involves a bidirectional functional connection between the brain and heart. We hypothesize that this connection could be extended to other organs using endocrine and autonomic nervous systems (ANS) as communication pathways. Th is implies a neuroendocrine interaction controlling particularly the cardiovascular function where the enzymatic cascade of the renin-angiotensin system (RAS) plays an essential role. It acts not only through its classic endocrine connection but also the ANS. In addition, the brain is functionally, anatomically, and neurochemically asymmetric. Moreover, this asymmetry goes even beyond the brain and it includes both sides of the peripheral nervous and neuroendocrine systems. We revised the available information and analyze the asymmetrical neuroendocrine bidirectional interaction for the cardiovascular control. Negative and positive correlations involving the RAS have been observed between brain, heart, kidney, gut, and plasma in physiologic and pathologic conditions. Th e central role of the peptides and enzymes of the RAS within this neurovisceral communication, as well as the importance of the asymmetrical distribution of the various RAS components in the pathologies involving this connection, are particularly discussed. In conclusion, there are numerous evidences supporting the existence of a neurovisceral connection with multiorgan involvement that controls, among others, the cardiovascular function. Th is connection is asymmetrically organized.

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A bihemispheric autonomic model for traumatic stress effects on health and behavior

Cited by 30 publications

References 51 publications

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

Sleep, Sleep Disorders, and Mild Traumatic Brain Injury. What We Know and What We Need to Know: Findings from a National Working Group

The Therapeutic Effect of Bilateral Alternating Stimulation Tactile Form Technology on the Stress Response

Bidirectional asymmetry in the neurovisceral communication for the cardiovascular control: New insights

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