A Bifunctional Spray Coating Reduces Contamination on Surfaces by Repelling and Killing Pathogens

Abstract

Surface-mediated transmission of pathogens is a major concern with regard to the spread of infectious diseases. Current pathogen prevention methods on surfaces rely on the use of biocides, which aggravate the emergence of antimicrobial resistance and pose harmful health effects. In response, a bifunctional and substrateindependent spray coating is presented herein. The bifunctional coating relies on wrinkled polydimethylsiloxane microparticles, decorated with biocidal gold nanoparticles to induce a "repel and kill" effect against pathogens. Pathogen repellency is provided by the structural hierarchy of the microparticles and their surface chemistry, whereas the kill mechanism is achieved using functionalized gold nanoparticles embedded on the microparticles. Bacterial tests with methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa reveal a 99.9% reduction in bacterial load on spraycoated surfaces, while antiviral tests with Phi6�a bacterial virus often used as a surrogate to SARS-CoV-2�demonstrate a 98% reduction in virus load on coated surfaces. The newly developed spray coating is versatile, easily applicable to various surfaces, and effective against various pathogens, making it suitable for reducing surface contamination in frequently touched, heavy traffic, and high-risk surfaces.

Synthesis, Characterization, and Docking Study of Novel Thioureidophosphonate-Incorporated Silver Nanocomposites as Potent Antibacterial Agents

“…Accordingly, BTP exhibited higher antiadhesion activity in all utilized concentrations towards MRSA (ATCC-43300) than MTP, which could be attributed to its superior hydrophobic characteristics as the non-polar parts (aromatic rings) exceeded the polar ones, based on its molecular formula (M.F), namely, C 34 H 32 N 4 O 6 P 2 S 2 , comparable to MTP with M.F of C 21 H 19 N 2 O 4 PS. Moreover, the electrostatic repulsion forces assessed between the negatively charged MTP/Ag NCs and MRSA (ATCC-43300) surface played a critical role [ 69 ]. As a result, MTP capped AgNPs in 100, 500, and 1000 formulations ascertained more significant increases (relative to raw) in the detachment ability against MRSA (ATCC-43300), most notably for 5 and 10 mg/mL.…”

Novel Antibacterial Materials and Coatings—A Perspective by the Editors

“…This is achieved by modifying the interfacial properties of medical devices without disrupting the bulk properties of materials. Over the past decade, a variety of surface modification or treatment techniques has emerged for the fabrication of antibacterial surfaces, either presenting bacteria-repellent properties [ 32 ], contact-killing mechanisms [ 33 ], or the release of antimicrobial agents [ 34 ]. Antibacterial surfaces have been functionalized by plasma polymerization to improve the functionality of the surface, enabling the binding of antimicrobial agents, which has received considerable research interest and has broad applications.…”