A bifunctional nanomodulator for boosting CpG-mediated cancer immunotherapy

Wang, Zhenzhen; Zhang, Yan; Liu, Zhen; Dong, Kai; Liu, Chaoqun; Ran, Xiang; Pu, Fang; Ju, Enguo; Ren, Jinsong; Qu, Xiaogang

doi:10.1039/c7nr04396a

Cited by 49 publications

(40 citation statements)

References 66 publications

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“…For example, MnO 2 NSs were designed as a unique support to integrate DOX and cytosine‐phosphate‐guanine (CpG)‐Ag NPs together for TME‐mediated DOX and CpG deliveries . Another case is that core–shell Au@MnO 2 (AM) NPs were produced for FL/PA/MR‐imaging guided O 2 ‐boosted PDT and immunotherapy by Cai group ( Figure a,b) .…”

Section: Therapeutic Applicationsmentioning

confidence: 99%

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Section: Therapeutic Applicationsmentioning

confidence: 99%

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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“…In this treatment, CuS nanoparticles transform the laser energy to the thermal energy to induce the cancer cell apoptosis, while CpG/LPS act as the bioadjuvant to stimulate the immunity against the tumors. Similarly, doxorubicin was encapsulated in MnO 2 ‐CpG‐silver nanoclusters via π–π stacking interactions, which significantly inhibited the growth of large solid tumors …”

Section: Delivery System For Provoking Antitumor Immunitymentioning

confidence: 99%

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Liu

Zhang

2019

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109

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Cancer immunotherapy is a promising cancer terminator by directing the patient's own immune system in the fight against this challenging disorder. Despite the monumental therapeutic potential of several immunotherapy strategies in clinical applications, the efficacious responses of a wide range of immunotherapeutic agents are limited in virtue of their inadequate accumulation in the tumor tissue and fatal side effects. In the last decades, increasing evidences disclose that nanotechnology acts as an appealing solution to address these technical barriers via conferring rational physicochemical properties to nanomaterials. In this Review, an imperative emphasis will be drawn from the current understanding of the effect of a nanosystem's structure characteristics (e.g., size, shape, surface charge, elasticity) and its chemical modification on its transport and biodistribution behavior. Subsequently, rapid‐moving advances of nanoparticle‐based cancer immunotherapies are summarized from traditional vaccine strategies to recent novel approaches, including delivery of immunotherapeutics (such as whole cancer cell vaccines, immune checkpoint blockade, and immunogenic cell death) and engineered immune cells, to regulate tumor microenvironment and activate cellular immunity. The future prospects may involve in the rational combination of a few immunotherapies for more efficient cancer inhibition and elimination.

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“…To avoid the undesired in vivo distribution of activated immune cells, nanomaterials, including liposomal, polymeric, or inorganic nanocarriers, have been developed to concentrate immunostimulatory drugs within tumors to boost the regional immunity . Several pioneering works have demonstrated the potential to stimulate the local T‐cell immune response by delivering immunomodulators with various types of carriers to achieve effective tumor elimination . Although great efforts have been devoted to enhancing the stability and the targeting efficiency of the delivered molecules, little has been investigated on the precise control of the interactions between immune cells and the cancer cells, which ultimately determines the therapeutic efficacy .…”

mentioning

confidence: 99%

In Situ Modification of the Tumor Cell Surface with Immunomodulating Nanoparticles for Effective Suppression of Tumor Growth in Mice

Zheng

Wang

et al. 2019

Advanced Materials

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Current cancer immunotherapies including chimeric antigen receptor (CAR)-based therapies and checkpoint immune inhibitors have demonstrated significant clinical success, but always suffer from immunotoxicity and autoimmune disease. Recently, nanomaterial-based immunotherapies are developed to precisely control in vivo immune activation in tumor tissues for reducing immune-related adverse events. However, little consideration has been put on the spatial modulation of interactions between immune cells and cancer cells to optimize the efficacy of cancer immunotherapies. Herein, a rational design of immunomodulating nanoparticles is demonstrated that can in situ modify the tumor cell surface with natural killer cell (NK cell)-activating signals to achieve in situ activation of tumorinfiltrating NK cells, as well as direction of their antitumor immunity toward tumor cells.Using these immunomodulating nanoparticles, the remarkable inhibition of tumor growth is observed in mice without noticeable side effects. This study provides an accurate immunomodulation strategy that achieves safe and effective antitumor immunity through in situ NK cell activation in tumors. Further development by constructing interactions with various immune cells can potentially make this nanotechnology become a general platform for the design of advanced immunotherapies for cancer treatments.

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A bifunctional nanomodulator for boosting CpG-mediated cancer immunotherapy

Cited by 49 publications

References 66 publications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

In Situ Modification of the Tumor Cell Surface with Immunomodulating Nanoparticles for Effective Suppression of Tumor Growth in Mice

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