A bifunctional hydrogel incorporated with CuS@MoS2 microspheres for disinfection and improved wound healing

Zhang, Xingyu; Zhang, Guannan; Zhang, Hongyu; Liu, Xiaoping; Shi, Jing; Shi, Huixian; Yao, Xiaohong; Chu, Paul K.

doi:10.1016/j.cej.2019.122849

Cited by 138 publications

(99 citation statements)

References 70 publications

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“…Moreover, the CuS/MoS 2 /PVA hydrogel could produce hyperthermia and reactive oxygen species under NIR/visual light to provide an antibacterial treatment. As shown in Figure 2 , after the bacteria were incubated with the hydrogel, the cell membranes were damaged to varying degrees [ 104 ]…”

Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Potential Mechanisms Of Photothermal Hydrogels For Wound Healing and Tissue Engineeringmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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“…In the same context of exploring the synergistic effects rendered by hyperthermia and ROS, Zhang and co-workers [ 86 ] reported the preparation of another promising photoactive hydrogel composite based on PVA but now embedded with CuS@MoS 2 microspheres ( Figure 30 A). After 15 min of co-irradiation at 660 nm (visible light) and 808 nm (NIR light) with an irradiance of 0.2 mW/cm 2 , the hydrogel was able to inactivate 99.3% of E. coli and 99.5% of S. aureus .…”

Section: Photosensitizing Dyesmentioning

confidence: 99%

“… ( A ) Schematic of preparation of CuS@MoS 2 –poly(vinyl alcohol) (PVA) hydrogel and ROS production after dual irradiation with visible (660 nm) and near-infrared (NIR) (808 nm) light; ( B ) Antibacterial rates after 2, 4 and 6 days of therapy; ( C ) Photographs of S . aureus -induced wound infections at days 0, 2, 6 and 14 (figure adapted from [ 86 ] with permission of Elsevier). …”

Section: Figurementioning

confidence: 99%

An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing

Vallejo

Moura

Faustino

et al. 2020

IJMS

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The concept behind photodynamic therapy (PDT) is being successfully applied in different biomedical contexts such as cancer diseases, inactivation of microorganisms and, more recently, to improve wound healing and tissue regeneration. The effectiveness of PDT in skin treatments is associated with the role of reactive oxygen species (ROS) produced by a photosensitizer (PS), which acts as a “double agent”. The release of ROS must be high enough to prevent microbial growth and, simultaneously, to accelerate the immune system response by recruiting important regenerative agents to the wound site. The growing interest in this subject is reflected by the increasing number of studies concerning the optimization of relevant experimental parameters for wound healing via PDT, namely, light features, the structure and concentration of the PS, and the wound type and location. Considering the importance of developing PSs with suitable features for this emergent topic concerning skin wound healing, in this review, a special focus on the achievements attained for each PS class, namely, of the non-porphyrinoid type, is given.

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“…In a Cu 2 S/MoS 2 hydrogel, there was an increase in the intensity of ⋅OH and 1 O 2 under dual irradiation of 808 nm NIR and 660 nm visible light. [ 230 ] Due to the photogenerated ROS and hyperthermal effects, the hydrogel lessened the bacterial activity and caused their death. Furthermore, the adsorption of water molecules preferably on the oxidative sites of photocatalysts will positively influence the H 2 O oxidation process.…”

Section: Ros‐induced Bacteria Inactivation Over 2d Semiconductorsmentioning

confidence: 99%

“…So far, various types of MoS 2 ‐based heterojunctions, including MoS 2 /Cu and MoS 2 /Ag 3 PO 4 , have been extensively assembled for the 1 O 2 ‐mediated antibacterial processes. [ 230,255 ]…”

Section: Ros‐induced Bacteria Inactivation Over 2d Semiconductorsmentioning

confidence: 99%

Solar‐Driven Photocatalytic Disinfection Over 2D Semiconductors: The Generation and Effects of Reactive Oxygen Species

Liu

Zeng

et al. 2020

Solar RRL

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Solar‐driven photocatalysis has been developing as a sustainable process and it holds appreciable promise to address the pollutants and risks posed by biohazards. The unique geometrical and electric features of 2D semiconductors have nurtured a variety of advanced photocatalytic bactericides where oxidative oxygen species are generated as the main disinfection reagents. Herein, the state‐of‐the‐art progress of solar‐driven photocatalytic disinfection based on 2D semiconductors with an emphasis on the generation and effects of various reactive oxygen species is summarized. Moreover, the immobility of the photocatalyst for practical applications is discussed. Finally, perspectives and challenges are presented to guide future research on photocatalytic disinfection.

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A bifunctional hydrogel incorporated with CuS@MoS2 microspheres for disinfection and improved wound healing

Cited by 138 publications

References 70 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

An Insight into the Role of Non-Porphyrinoid Photosensitizers for Skin Wound Healing

Solar‐Driven Photocatalytic Disinfection Over 2D Semiconductors: The Generation and Effects of Reactive Oxygen Species

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