A bibliometric analysis of the top 50 most cited papers in cartilage regeneration

Abstract

Purpose: To investigate the efficacy and safety of UC-MSC(umbilical cord mesenchymal stem cells, UC-MSC) transplantation for osteoarthritis. Methods: Three patients with knee osteoarthritis, admitted by our hospital from May 2016 to July 2016, were received UC-MSC transplantation once with total cellular number of UC-MSC was 5~7Â10 7 by intra-articular injection. These patients were followed up regularly for 3 months after transplantation. The clinical situation and recovery of knee joint function were observed. Results: After transplantation the joint pain relieve significantly,the recovery of the ability of daily activities of the three patients improved obviously. No significant difference was observed when compared posttreatment with pre-treatment of biochemical parameters, which contains blood routine, hepatic function, renal function. Conclusions: The intra-articular injection of UC-MSC transplantation could ameliorate clinical manifestations and delay progression of osteoarthritis. It may be safe and effective in the treatment of osteoarthritis , but further observation was still required to evaluate its long term efficacy.