A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021

Abstract

Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research.Methods: The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software.Results: A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. Circulation Research was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study.Conclusion: We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.

Exosomes and the cardiovascular system: role in cardiovascular health and disease

“…Ischaemic stroke Chen et al, 2017;Ji et al, 2016;Li et al, 2017;Zhou et al, 2018 miR-30e, miR-92a Atherosclerosis Ma et al, 2021;Wang et al, 2019 miR-1, miR-133b, miR-183, miR-208, miR-208b, miR-499 Myocardial infarction Deddens et al, 2016;Ma et al, 2021;Zhao et al, 2019 miR-21, miR-92a, miR-126, miR-143, miR-181b, miR-221 Peripheral artery disease Sorrentino et al, 2020 miR-517-5p, miR-520a-5p, miR-525-5p Gestational hypertension and preeclampsia Hromadnikova et al, 2019 show an increase in serum concentration of exosomes and exosomal levels of the brain-specific miRNAs miR-9 and miR-124. This rise in miR-9 and miR-124 was positively correlated to infarct volumes, which suggests the potential use of exosomes to assess the degree of damage caused by ischaemic injury (Ji et al, 2016;Zara et al, 2020).…”

An Overview of Current Research on Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Bibliometric Analysis From 2009 to 2021

“…Notably, the period of the included studies has a significant impact on the bibliometric results, therefore, timely updating is essential to grasp the research frontier. Recently, MSC-EVs have become a research hotspot, while the relevant bibliometric analysis studies are limited, mainly focusing on the EVs or exosomes without a specific source (Yiran et al, 2017;Wang et al, 2019), or the role of exosomes in a particular sort of disease, including cardiovascular disease, cancer (Ma et al, 2021;Shi et al, 2021;Teles et al, 2021). In this study, we performed a bibliometric analysis of literature on MSC-EVs published from 2009 to 2021, covering the number of publications, countries, institutions, authors, journals, and keywords, to summarise current thematic trends and hot topics and provide guidance for future research.…”

Research Trends on Pulmonary Rehabilitation: A Bibliometric Analysis From 2011 to 2020

“…High-frequency keywords could reflect research hot spots ( 30 ). After calculation by VOSviewer, 10,747 keywords in total were extracted from all 4,521 publications.…”