“…A wrong partitioning will certainly result in an unbalanced health service and might cause extensive flow of patients from one microregion to another for the sole purpose of a required procedure not available in the patient's home microregion, and thus it may increase cost and reduce quality. [25] Salt spreading operations Antwerp, Belgium MO H MHP Bergey et al [5] Electrical power districting Republic of Ghana MO MH GA Bozkaya et al [6] Electoral problem Edmonton, Canada SO MH TS Galvão et al [19] Delivery problem São Paulo, Brazil MO H WVD Tavares-Pereira et al [32] Public transportation Paris, France MO MH GA Haugland et al [20] Routing problem Benchmark instances SO MH TS Datta et al [14] Land-use management Southern Portugal MO MH GA Ricca and Simeone [28] Electoral problem Italian regions MO MH LS Ricca et al [27] Electoral problem Italian regions MO H WVD Novaes et al [26] Delivery problem São Paulo, Brazil MO H VD Salazar-Aguilar et al [30] Distribution problem Monterrey, Mexico MO EX ϵ-constraint Shirabe [31] School bus transportation Sweden SO H Map algebra Contreras et al [8] Combined facility location and network design Benchmark instances SO EX MILP Knight et al [21] Locating emergency medical services Wales SO MH GA Datta et al [15] Census tracts London, Ontario, Canada MO MH GA Datta et al [13] Healthcare East England MO MH GA Lin et al [23] Determination of resource levels in surgical services Benchmark instances MO MH GA Benzarti et al [4] Home healthcare France MO EX MILP Ríos-Mercado and López-Pérez [29] Distribution problem Monterrey, Mexico SO EX MILP Assis et al [1] Power meter reading São Paulo, Brazil MO MH GRASP Li et al [22] Urban land use Southern California, USA SO EX MILP Liu et al [24] Periodic vehicle routing problem The Parana State has a total area of 199,314.85 km 2 and its population (close to 11 million inhabitants) is around 5% of the total Brazilian population. The health services in Parana are offered through a public system managed by the government and also complemented by private companies, but the latter are paid services affordable only by a section of the population.…”