A Bi-national Analysis of 252 Pancreatic Resections for Chronic Pancreatitis with Regard to Incidental Carcinoma Sequence and Overall Postoperative Outcome

Malinka, Thomas; Klein, Fritz; Thu, Trang Le; Rösch, Christiane Sophie; Wundsam, Helwig; Biebl, Matthias; Pratschke, Johann; Bahra, Marcus; Függer, R.

doi:10.21873/anticanres.12812

Cited by 7 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, because there were many missing values and only five cases of PDAC, the regression model of risk factors was not successful in the group of patients without a pancreatic mass ( n = 110). Furthermore, the proportion (4.5%, 5/110) of patients with PDAC without a pancreatic mass was similar to the results of previous studies (5–7.1%) [ 32 , 33 ]. This may be due to the false image caused by the CP itself and the high proportion of cancer in the group of cases with pancreatic masses (29/94).…”

Section: Discussionsupporting

confidence: 89%

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

et al. 2022

View full text Add to dashboard Cite

Objectives Pancreatic calcifications (PC) are considered specific for chronic pancreatitis (CP), but PC may also be present in non-CP diseases. The aims are to understand the pattern of calcifications in different diseases and to determine they were related to malignant diseases. Methods A retrospective study was performed including patients with PC or CP undergoing surgery in the Department of General Surgery of Ruijin Hospital from January 2003 to June 2018. Results PC were observed in 168 (4.5%) of the 3755 patients with pancreatic lesions treated during the study period. The majority of patients with PC had three kinds of CP (73.2%) while 26.8% had other five kinds of non-CP diseases. In patients with non-CP diseases, the incidence of PC in malignant intraductal papillary mucinous neoplasm (IPMN) was significantly higher than benign IPMN (8.3% vs. 0.7%, p = 0.004). In patients of CP with pancreatic mass (n = 81), PC (Odds ratio = 28.6, p = 0.000), advanced age (> 55 years) and parenchymal atrophy were independent predictors for malignancy. In patients of CP without pancreatic mass (n = 110), there were 82 cases (74.5%) with PC and 5 cases (4.5%) with pancreatic ductal adenocarcinoma. The regression model of risk factors was not successful. Conclusions The disease spectrum with PC was very diverse. PC may be related to malignant IPMN in non-CP diseases and is related to malignancy in the patients of CP with pancreatic mass and indications for resection.

show abstract

Section: Discussionsupporting

confidence: 89%

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A total of 3110 articles were initially identified, and 75 studies remained after removing duplicates, irrelevant articles, and those that met our exclusion criteria (Figure 1). Characteristics of included articles are described in Table 1 …”

Section: Resultsmentioning

confidence: 99%

Etiology, Diagnosis, and Modern Management of Chronic Pancreatitis

Cohen

Kent

2023

JAMA Surg

View full text Add to dashboard Cite

ImportanceThe incidence of chronic pancreatitis is 5 to 12 per 100 000 adults in industrialized countries, and the incidence is increasing. Treatment is multimodal, and involves nutrition optimization, pain management, and when indicated, endoscopic and surgical intervention.ObjectivesTo summarize the most current published evidence on etiology, diagnosis, and management of chronic pancreatitis and its associated complications.Evidence ReviewA literature search of Web of Science, Embase, Cochrane Library, and PubMed was conducted for publications between January 1, 1997, and July 30, 2022. Excluded from review were the following: case reports, editorials, study protocols, nonsystematic reviews, nonsurgical technical publications, studies pertaining to pharmacokinetics, drug efficacy, pilot studies, historical papers, correspondence, errata, animal and in vitro studies, and publications focused on pancreatic diseases other than chronic pancreatitis. Ultimately, the highest-level evidence publications were chosen for inclusion after analysis by 2 independent reviewers.FindingsA total of 75 publications were chosen for review. First-line imaging modalities for diagnosis of chronic pancreatitis included computed tomography and magnetic resonance imaging. More invasive techniques such as endoscopic ultrasonography allowed for tissue analysis, and endoscopic retrograde cholangiopancreatography provided access for dilation, sphincterotomy, and stenting. Nonsurgical options for pain control included behavior modification (smoking cessation, alcohol abstinence), celiac plexus block, splanchnicectomy, nonopioid pain medication, and opioids. Supplemental enzymes should be given to patients with exocrine insufficiency to avoid malnutrition. Surgery was superior to endoscopic interventions for long-term pain control, and early surgery (&lt;3 years from symptom onset) had more superior outcomes than late surgery. Duodenal preserving strategies were preferred unless there was suspicion of cancer.Conclusions and RelevanceResults of this systematic review suggest that patients with chronic pancreatitis had high rates of disability. Strategies to improve pain control through behavioral modification, endoscopic measures, and surgery must also accompany management of the sequalae of complications that arise from endocrine and exocrine insufficiency.

show abstract

“…Secondly, PaCa may be an incidental nding of CP during pancreatic surgery. PaCa was found by histopathology in 7.1% of the CP surgical specimens reported by Malinka et al 29 . This was approximately equal to the rate in our study, in which the proportion of cases with PaCa detected during hospitalization was 7.0% among the articles that provided data on PaCa or death alone.…”

Section: Paca and Prognosismentioning

confidence: 90%

Regional Variations in Distribution, Diagnosis and Treatment of Chronic Pancreatitis in Mainland China: A Systematic Review of Case Articles Over 40 Years

Wang

Jiang

Meng³

et al. 2020

SSRN Journal

View full text Add to dashboard Cite

A Bi-national Analysis of 252 Pancreatic Resections for Chronic Pancreatitis with Regard to Incidental Carcinoma Sequence and Overall Postoperative Outcome

Cited by 7 publications

References 21 publications

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

Clinical significance of pancreatic calcifications: a 15-year single-center observational study

Etiology, Diagnosis, and Modern Management of Chronic Pancreatitis

Regional Variations in Distribution, Diagnosis and Treatment of Chronic Pancreatitis in Mainland China: A Systematic Review of Case Articles Over 40 Years

Contact Info

Product

Resources

About