A bi-functionalized metal-organic framework based on N-methylation and Eu3+ post-synthetic modification for highly sensitive detection of 4-Aminophenol (4-AP), a biomarker for aniline in urine

Jin, Yingmin; Yan, Bing

doi:10.1016/j.talanta.2021.122209

Cited by 30 publications

(16 citation statements)

References 53 publications

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“…In order to elucidate the possible sensing mechanism of 1 for monitoring of HT and HIAA, some experiments were systematically performed. First, PXRD patterns and IR spectra of 1 after immersion in HT and HIAA solutions are similar to those of the as-synthesized 1 (Figures S1 and S5), indicating that the luminescence quenching does not result from decomposition of the framework. , Second, to further understand the quenching mechanism of the luminescence sensor, the luminescence lifetimes of 1 at 546 nm with and without HT and HIAA were measured. As seen in Figure S20 and Table S5, the luminescentce lifetimes of 1 displayed different degrees of decay after HT and HIAA were added, suggesting a dynamic quenching process should be responsible for the quenching effect. ,, As is known to all, luminescence quenching may also be attributed to the competitive absorption of the excitation light between sensors and analytes. , It can be observed that the absorption spectra of HT and HIAA displayed an obvious overlap with the absorption band of 1 , indicating the occurrence of a competitive absorption between 1 and the biomarkers.…”

Section: Resultsmentioning

confidence: 65%

“…First, PXRD patterns and IR spectra of 1 after immersion in HT and HIAA solutions are similar to those of the as-synthesized 1 (Figures S1 and S5), indicating that the luminescence quenching does not result from decomposition of the framework. 42,43 Second, to further understand the quenching mechanism of the luminescence sensor, the luminescence lifetimes of 1 at 546 nm with and without HT and HIAA were measured. As seen in Figure S20 and Table S5, the luminescentce lifetimes of 1 displayed different degrees of decay after HT and HIAA were added, suggesting a dynamic quenching process should be responsible for the quenching effect.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…In recent years, the detection of biomarkers has become more and more important in health risk assessment and early diagnosis of diseases as well as monitoring in the process of treatment. − Among them, serotonin (5-hydroxytryptamine, HT), an inhibitory neurotransmitter in the central nervous system, at an abnormal level can cause a variety of diseases, including carcinoid, schizophrenia, migraine, anxiety disorder, Alzheimer’s disease (AD), and so on . Abnormalities of HT and its metabolite 5-hydroxyindole-3-acetic acid (HIAA) can be detected in the blood plasma or urine components of patients with malignant tumors; thus, HT and HIAA are regarded as discriminating biomarkers for the early detection of carcinoid tumors .…”

Section: Introductionmentioning

confidence: 99%

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Dual-Functional Metal–Organic Framework for Luminescent Detection of Carcinoid Biomarkers and High Proton Conduction

Zhou

Liu

et al. 2021

Inorg. Chem.

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It remains a challenge to exploit dual-functional metal–organic frameworks (MOFs) for applications, including luminescence detection and proton conduction. With the deliberate selection of the bifunctional organic ligand 5-sulfoisophthalic acid monosodium salt (NaH2bts), and the phosphonic acid ligand N,N′-piperazine (bismethylenephosphonic acid; H4L), a robust three-dimensional (3D) noninterpenetrating dual-functional MOF, [Tb(H2L)(H2bts)(H2O)]·H2O (1), has been synthesized hydrothermally. On the basis of the excellent thermal and chemical as well as superior luminescence stabilities in water and solutions with different pHs, 1 can serve as the simple, rapid, and highly selective and sensitive luminescence detection of the carcinoid biomarkers 5-hydroxytryptamine (HT) and its metabolite 5-hydroxyindole-3-acetic acid (HIAA) with detection limits of nanomolar magnitude in water and in simulated blood plasma and urine systems. Due to the change in the signals that could be readily differentiated by the naked eye under a UV lamp, a portable test paper has been developed. The probable quenching mechanisms are discussed in detail. In addition, a great number of hydrogen-bonding networks are formed among the uncoordinated carboxylic oxygen atoms, sulfonate oxygen atoms, protonated nitrogen atoms, and water molecules, which provide potential proton-hopping sites for proton conduction, leading to a maximum proton conductivity of 2.3 × 10–4 S cm–1 at 368 K and 95% relative humidity. The above results suggest that rationally designed dual-functional MOFs can open an avenue for the development of occupational diagnostic tools and alternative energy technology.

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Section: Resultsmentioning

confidence: 65%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dual-Functional Metal–Organic Framework for Luminescent Detection of Carcinoid Biomarkers and High Proton Conduction

Zhou

Liu

et al. 2021

Inorg. Chem.

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“…As shown in Figure 3 a, the powder X-ray diffraction pattern of UA/Cu 2+ @Tb-MOFs collected from UA aqueous solution is in good agreement with that of Cu 2+ @Tb-MOFs and Tb-MOFs. This result not only indicates the structural stability of Cu 2+ @Tb-MOFs, but also excludes the possibility of fluorescence recovery caused by structural collapse or reorganization [ 48 , 49 ]. The luminescence lifetime is a very important parameter to explore the fluorescence recovery mechanism of Cu 2+ @Tb-MOFs; we determined the fluorescence lifetime of Tb-MOFs, Cu 2+ @Tb-MOFs and UA/Cu 2+ @Tb-MOFs samples.…”

Section: Resultsmentioning

confidence: 89%

A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

et al. 2022

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As an important biomarker in urine, the level of uric acid is of importance for human health. In this work, a Cu(II) functionalized metal–organic framework (Cu2+@Tb-MOFs) is designed and developed as a novel fluorescence probe for wide-range uric acid detection in human urine. The study shows that this fluorescence platform demonstrated excellent pH-independent stability, high water tolerance, and good thermal stability. Based on the strong interaction between metal ions and uric acid, the designed Cu2+@Tb-MOFs can be employed as efficient turn-on fluorescent probes for the detection of uric acid with wide detection range (0~104 µM) and high sensitivity (LOD = 0.65 µM). This probe also demonstrates an anti-interference property, as other species coexisted, and the possibility for recycling. The sensing mechanisms are further discussed at length. More importantly, we experimentally constructed a molecular logic gate operation based on this fluorescence probe for intelligent detection of uric acid. These results suggest the Cu(II) functionalized metal–organic framework can act as a prominent candidate for personalized monitoring of the concentration of uric acid in the human urine system.

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“…Such materials have been used in the detection of analytes such as ionic species, [68] small molecules, [69] volatile organic molecules, [70] biomolecules [71] etc . For example, Yan ’s group has used lanthanide MOFs [72] to sense and detect molecules such as Levofloxacin, [73] pyrethroids, [74] nitrophenols, [75] mitoxantrone, [76] diphenyl phosphate, [77] 4‐aminophenol [78] and 5‐fluorouracil [79] . Hao et.…”

Section: Sensitized Lanthanide Emissive Mofs As Sensorsmentioning

confidence: 99%

Sensitized Lanthanide Photoluminescence Based Sensors–a Review

Maitra

Afzal

2022

Helvetica Chimica Acta

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Photoluminescent supramolecular systems such as hydrogels and metal‐organic frameworks (MOFs) can be useful for applications in many areas. In aqueous media, lanthanides exhibit luminescence by sensitization through covalently linked chromophores (antenna effect), making them valuable for sensing and imaging applications. Fluorescent sensing by sensitized lanthanide emission in gels and MOFs provides a simple and rapid detection of analytes with high sensitivity and selectivity. This review presents the gradual evolution and the intriguing conceptualization of sensitized luminescence of lanthanides spanning the sensing of biomolecules, drugs, small organic molecules and enzymes employing hydrogels or MOFs as the sensing platform.

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A bi-functionalized metal-organic framework based on N-methylation and Eu3+ post-synthetic modification for highly sensitive detection of 4-Aminophenol (4-AP), a biomarker for aniline in urine

Cited by 30 publications

References 53 publications

Dual-Functional Metal–Organic Framework for Luminescent Detection of Carcinoid Biomarkers and High Proton Conduction

Dual-Functional Metal–Organic Framework for Luminescent Detection of Carcinoid Biomarkers and High Proton Conduction

A Novel Turn-On Fluorescence Probe Based on Cu(II) Functionalized Metal–Organic Frameworks for Visual Detection of Uric Acid

Sensitized Lanthanide Photoluminescence Based Sensors–a Review

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