A bi-directional DEM-PBM coupling to evaluate chipping and abrasion of pharmaceutical tablets

Cabiscol, Ramon; Finke, Jan Henrik; Kwade, Arno

doi:10.1016/j.apt.2021.06.002

Cited by 12 publications

(4 citation statements)

References 54 publications

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“…The friability test measures weight loss caused by abrasion on the tablet surface. 22 The test results demonstrated that EAFG film-coated tablets exhibited excellent friability, at 0.02%. This result is consistent with the findings of Yunarto et al (2016), who observed that Opadry AMB II coating material in the formulation of dihydroartemisininpiperaquine (DHP) film-coated tablets was able to keep the tablets strong and not brittle with a friability value of 0.02%.…”

Section: Resultsmentioning

confidence: 93%

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

2024

TJNPR

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Catechins from gambir leaves have high antioxidant activity. 4 They can inhibit the activity of the HMG-CoA reductase and lipase enzymes. The inhibitory activity of catechins increases with their concentration, lowering total cholesterol levels. 5 The development of raw materials in the form of the ethyl acetate fraction of gambir leaf extract will improve the quality of raw materials due to the high catechin content in the ethyl acetate fraction of gambir (EAFG), cleaner physical appearance, lower water, and ash content. Catechin compounds are less stable in the presence of humidity and water, making them more easily oxidized. 6 Also, catechins are less stable to UV light and visible light. 7 One effort to increase the stability of catechins in EAFG is by formulating them in film-coated tablet dosage forms. Film-coated tablets can increase product stability by containing active substances sensitive to moisture and light and easily oxidized. 8 The present study aimed to produce and evaluate film-coated tablets made from the ethyl acetate fraction of gambir leaves. The quality of film-coated tablets was assessed based on their physicochemical properties, drug release, and stability during storage. Materials and Methods Preparation of gambir leaf extractThe extract of gambir leaves was prepared from plants obtained from Mungka District,

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Section: Resultsmentioning

confidence: 93%

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

2024

TJNPR

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“…m i is the particle mass fraction in size group of N groups, K i is the breakage constant and b ij is the breakage distribution parameter defining particle mass fraction formed in size group i from group j (ref. 112).…”

Section: Replacement Model For Particle Crushingmentioning

confidence: 99%

“…Population balance modelling is a semi-empirical approach with simplified mechanical consideration of the particle crushing process used widely in chemistry and pharmaceutics 110,111 . Population balance modelling has recently been coupled with the replacement approach in DEM to better capture the mechanical process 112 .…”

Section: Crushable Particlesmentioning

confidence: 99%

The role of particle shape in computational modelling of granular matter

Zhao,

Luding

2023

Nat Rev Phys

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Granular matter is ubiquitous in nature and is present in diverse forms in important engineering, industrial and natural processes. Particle-based computational modelling has become indispensable to understand and predict the complex behaviour of granular matter in these processes. The success of modern computational models requires realistic and efficient consideration of particle shape. Realistic particle shapes in naturally occurring and engineered materials offer diverse challenges owing to their multiscale nature in both length and time. Furthermore, the complex interactions with other materials, such as interstitial fluids, are highly nonlinear and commonly involve multiphysics coupling. This Technical Review presents a comprehensive appraisal of state-of-the-art computational models for granular particles of either naturally occurring shapes or engineered geometries. It focuses on particle shape characterization, representation and implementation, as well as its important effects. In addition, the particles may be hard, highly deformable, crushable or phase transformable; they might change their behaviour in the presence of interstitial fluids and are sensitive to density, confining stress and flow state. We describe generic methodologies that capture the universal features of granular matter and some unique approaches developed for special but important applications. Sections• Consideration of shape effects in coupled simulations of granular particles and environmental fluids requires revamped theories and methods to faithfully reflect their underpinning multiphase, multiphysics nature.• Incorporating realistic particle shapes in granular matter modelling must harness the latest advances in parallel computing and machine learning for effective large-scale computations.Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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“…In applications when solid binding agents are used to generate particle agglomerates or for particles of high mechanical strength, bonded particle models, along the lines of the force models of Brown, Chen, and Ooi [ 29 ] or Potyondy and Cundall [ 30 ], are typically employed within DEM simulations. Examples of this treatment include the breakage of L-threonine crystals [ 31 ] and the abrasion of pharmaceutical tablets [ 32 ]. In solids handling for biomass processing, constituent particles are often held together in agglomerates via liquid bridging.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Regimes of Particle Behavior upon Impact via the Discrete Element Method

Nguyen,

Curtis,

Salari

2024

Pharmaceutics

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Discrete element method simulations are conducted to probe the various regimes of post-impact behavior of particles with solid surfaces. The impacting particles are described as spherical agglomerates consisting of smaller constituent (or primary) particles held together via surface adhesion. Under the influence of a wide range of impact velocities and particle surface energies, five distinct behavioral regimes—rebounding, vibration, fragmentation, pancaking, and shattering—are identified, and force transmission patterns are linked to post-impact behavior. In the rebounding regime, the coefficient of restitution decreases linearly as impact velocity increases and the particle agglomerate experiences compaction. In the fragmentation regime, rebound velocity generally decreases with increasing fragment size. The rebound velocity of fragments decreases with time except for the smallest fragments, which can increase in velocity due to collisions with other fragments of high velocity. Particle breakage in the pancaking regime does not follow common mechanistic models of breakage.

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A bi-directional DEM-PBM coupling to evaluate chipping and abrasion of pharmaceutical tablets

Cited by 12 publications

References 54 publications

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

Evaluation of Film-Coated Tablets of Ethyl Acetate Fraction of Uncaria gambir (Hunter) Roxb

The role of particle shape in computational modelling of granular matter

Exploring the Regimes of Particle Behavior upon Impact via the Discrete Element Method

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