A bélmikrobiom, a metabolikus betegségek és a                     hypertonia kapcsolatának irodalmi áttekintése

Barna, István; Nyúl, Dóra; Szentes, Tamás; Schwab, Richard J.

doi:10.1556/650.2018.30787

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…Osteoarthritis is a multifactorial and slowly progressive disease, resulting in a difficult early diagnosis through radiography or plasma biochemical analysis [23]. Different studies have revealed the relationship between cardiovascular disease, obesity, type 2 diabetes, and osteoarthritis, focusing on the role of the metabolic syndrome in provoking joint and bone damage [24,25].…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome of Healthy and Arthritic Dogs

Cintio

Scarsella

Sgorlon

et al. 2020

Veterinary Sciences

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Several studies have underlined the interplay among host-microbiome and pathophysiological conditions of animals. Research has also focused specifically on whether and how changes in the gut microbiome have provoked the occurrence of pathological phenomena affecting cartilage and joints in humans and in laboratory animals. Here, we tried to evaluate the relationship between the gut microbiome and the hip and elbow arthritis in owned dogs. The study included 14 dogs suffering from chronic arthritis (AD) and 13 healthy dogs (HD). After the first visit and during the period of the study, the dogs, under the supervision of the owner, were fed a semi-moist complete diet supplemented with omega 3 fatty acids. Feces and blood samples were collected in the clinic at the first visit (T0) and after days (T45). The plasma C-reactive protein (CRP) was higher, and the serum vitamin B12 and folate concentrations were lower (p < 0.05) in the AD group in comparison to the HD group. Data of the fecal microbiome showed that the relative abundances of the genus Megamonas were higher in AD (p < 0.001), while the relative abundance of the families Paraprevotellaceae, Porphyromonadaceae, and Mogibacteriaceae was significantly lower in comparison to HD. The results of the study identified several bacterial groups that differed significantly in the fecal microbiome between healthy and diseased dogs. If the observed differences in fecal bacterial composition predispose dogs to hip and elbow arthritis or if these differences reflect a correlation with these conditions deserves further investigation.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiome of Healthy and Arthritic Dogs

Cintio

Scarsella

Sgorlon

et al. 2020

Veterinary Sciences

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“…22 These microbiotas are closely associated with nutrition, metabolism, immunity, and health of the host. 23 - 25 In fact, the microbiome has been referred to as the “second genome” of animals. 26 - 30 With regard to the great effect the gut microbiota exerts on the host, studying the gut microbiota of plateau zokor provides new insight into its special adaptive mechanism.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiome Changes in Captive Plateau Zokors (Eospalax baileyi)

Liu

Song

Yan

et al. 2021

Evol Bioinform Online

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Wild-caught animals must cope with drastic lifestyle and dietary changes after being induced to captivity. How the gut microbiome structure of these animals will change in response receives increasing attention. The plateau zokor ( Eospalax baileyi), a typic subterranean rodent endemic to the Qinghai-Tibet plateau, spends almost the whole life underground and is well adapted to the environmental pressures of both plateau and underground. However, how the gut microbiome of the plateau zokor will change in response to captivity has not been reported to date. This study compared the microbial community structure and functions of 22 plateau zokors before (the WS group) and after being kept in captivity for 15 days (the LS group, fed on carrots) using the 16S rRNA gene via high-throughput sequencing technology. The results showed that the LS group retained 973 of the 977 operational taxonomic units (OTUs) in the WS group, and no new OTUs were found in the LS group. The dominant bacterial phyla were Bacteroides and Firmicutes in both groups. In alpha diversity analysis, the Shannon, Sobs, and ACE indexes of the LS group were significantly lower than those of the WS group. A remarkable difference ( P < 0.01) between groups was also detected in beta diversity analysis. The UPGMA clustering, NMDS, PCoA, and Anosim results all showed that the intergroup difference was significantly greater than the intragroup difference. And compared with the WS group, the intragroup difference of the gut microbiota in the LS group was much larger, which failed to support the assumption that similar diets should drive convergence of gut microbial communities. PICRUSt revealed that although some functional categories displayed significant differences between groups, the relative abundances of these categories were very close in both groups. Based on all the results, we conclude that as plateau zokors enter captivity for a short time, although the relative abundances of different gut microbiota categories shifted significantly, they can maintain almost all the OTUs and the functions of the gut microbiota in the wild. So, the use of wild-caught plateau zokors in gut microbial studies is acceptable if the time in captivity is short.

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“…It is a multifactorial disorder with a very complicated etiology, where the triggering factor is still a “mystery”. Recent studies, confirming an association between type 2 diabetes, cardiovascular diseases, obesity and OA, have focused on the role of the metabolic syndrome in inducing or exacerbating joint damage [6, 7]. There is some evidence showing that the linking factor between metabolic abnormalities and the OA onset could be represented by the persistence of a chronic low-grade systemic inflammation [8].…”

Section: Introductionmentioning

confidence: 99%

A correlation between intestinal microbiota dysbiosis and osteoarthritis

Szychlinska

Rosa

Castorina

et al. 2019

Heliyon

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Osteoarthritis (OA) is a degenerative disease of the articular cartilage, resulting in pain and total joint disability. Recent studies focused on the role of the metabolic syndrome in inducing or worsening joint damage suggest that chronic low-grade systemic inflammation may represent a possible linking factor. This finding supports the concept of a new phenotype of OA, a metabolic OA. The gut microbiome is fundamental for human physiology and immune system development, among the other important functions. Manipulation of the gut microbiome is considered an important topic for the individual health in different medical fields such as medical biology, nutrition, sports, preventive and rehabilitative medicine. Since intestinal microbiota dysbiosis is strongly (http://creativecommons.org/licenses/by-nc-nd/4.0/). associated with the pathogenesis of several metabolic and inflammatory diseases, it is conceivable that also the pathogenesis of OA might be related to it. However, the mechanisms and the contribution of intestinal microbiota metabolites in OA pathogenesis are still not clear. The aim of this narrative review is to review recent literature concerning the possible contribution of dysbiosis to OA onset and to discuss the importance of gut microbiome homeostasis maintenance for optimal general health preservation.

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A bélmikrobiom, a metabolikus betegségek és a hypertonia kapcsolatának irodalmi áttekintése

Cited by 10 publications

References 18 publications

Gut Microbiome of Healthy and Arthritic Dogs

Gut Microbiome of Healthy and Arthritic Dogs

Gut Microbiome Changes in Captive Plateau Zokors (Eospalax baileyi)

A correlation between intestinal microbiota dysbiosis and osteoarthritis

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