A behavioral measure of the cochlear changes underlying temporary threshold shifts

Howgate, Stella; Plack, Christopher J.

doi:10.1016/j.heares.2011.03.009

Cited by 15 publications

(13 citation statements)

References 44 publications

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“…Kujawa and Liberman (2009) showed temporary threshold shifts, in response to 2 h of 100 dB SPL noise, of 40 dB one day post-exposure and 20–25 dB three days post-exposure in the ABR measured at 3 and 5 kHz. For comparison in humans, Howgate and Plack (2011) report a 10.8 dB temporary threshold shift at 4 kHz immediately after attending a music venue with a mean equivalent exposure level of 99 dBA. It may be that cochlear synaptopathy in humans only occurs for exposure levels close to or greater than those that produce a permanent threshold shift.…”

Section: Discussionmentioning

confidence: 99%

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology

Prendergast

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Munro³

et al. 2017

Hearing Research

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Noise-induced cochlear synaptopathy has been demonstrated in numerous rodent studies. In these animal models, the disorder is characterized by a reduction in amplitude of wave I of the auditory brainstem response (ABR) to high-level stimuli, whereas the response at threshold is unaffected. The aim of the present study was to determine if this disorder is prevalent in young adult humans with normal audiometric hearing. One hundred and twenty six participants (75 females) aged 18–36 were tested. Participants had a wide range of lifetime noise exposures as estimated by a structured interview. Audiometric thresholds did not differ across noise exposures up to 8 kHz, although 16-kHz audiometric thresholds were elevated with increasing noise exposure for females but not for males. ABRs were measured in response to high-pass (1.5 kHz) filtered clicks of 80 and 100 dB peSPL. Frequency-following responses (FFRs) were measured to 80 dB SPL pure tones from 240 to 285 Hz, and to 80 dB SPL 4 kHz pure tones amplitude modulated at frequencies from 240 to 285 Hz (transposed tones). The bandwidth of the ABR stimuli and the carrier frequency of the transposed tones were chosen to target the 3–6 kHz characteristic frequency region which is usually associated with noise damage in humans. The results indicate no relation between noise exposure and the amplitude of the ABR. In particular, wave I of the ABR did not decrease with increasing noise exposure as predicted. ABR wave V latency increased with increasing noise exposure for the 80 dB peSPL click. High carrier-frequency (envelope) FFR signal-to-noise ratios decreased as a function of noise exposure in males but not females. However, these correlations were not significant after the effects of age were controlled. The results suggest either that noise-induced cochlear synaptopathy is not a significant problem in young, audiometrically normal adults, or that the ABR and FFR are relatively insensitive to this disorder in young humans, although it is possible that the effects become more pronounced with age.

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Section: Discussionmentioning

confidence: 99%

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology

Prendergast

Guest

Munro³

et al. 2017

Hearing Research

Self Cite

191

204

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“…For example, in a recent study of temporary threshold shift, a noise level of 98 dB A L eq was recorded in Manchester nightclubs (Howgate & Plack, 2011). Considerable neuropathy has been observed in mice exposed to just 84 dB SPL for a week (Maison, Usubuchi, & Liberman, 2013).…”

Section: Animal Studies Of Noise-induced Cochlear Neuropathymentioning

confidence: 99%

Perceptual Consequences of “Hidden” Hearing Loss

2014

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Dramatic results from recent animal experiments show that noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity permanently. This cochlear neuropathy has been described as hidden hearing loss, as it is not thought to be detectable using standard measures of audiometric threshold. It is possible that hidden hearing loss is a common condition in humans and may underlie some of the perceptual deficits experienced by people with clinically normal hearing. There is some evidence that a history of noise exposure is associated with difficulties in speech discrimination and temporal processing, even in the absence of any audiometric loss. There is also evidence that the tinnitus experienced by listeners with clinically normal hearing is associated with cochlear neuropathy, as measured using Wave I of the auditory brainstem response. To date, however, there has been no direct link made between noise exposure, cochlear neuropathy, and perceptual difficulties. Animal experiments also reveal that the aging process itself, in the absence of significant noise exposure, is associated with loss of auditory nerve fibers. Evidence from human temporal bone studies and auditory brainstem response measures suggests that this form of hidden loss is common in humans and may have perceptual consequences, in particular, regarding the coding of the temporal aspects of sounds. Hidden hearing loss is potentially a major health issue, and investigations are ongoing to identify the causes and consequences of this troubling condition.

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“…Both level and duration are considerably higher than the levels used in this experiment. Howgate and Plack (2011) investigated cochlear changes in one ear after recreational noise for subjects with regular recreational exposure. They measured sound level values ranging from 90 -103 dB (A) averaging to 99 dB (A).…”

Section: Observed Effectsmentioning

confidence: 99%

Short-term music-induced hearing loss after sound exposure to discotheque music: The effectiveness of a break in reducing temporary threshold shift

Helleman

Dreschler

2014

International Journal of Audiology

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A behavioral measure of the cochlear changes underlying temporary threshold shifts

Cited by 15 publications

References 44 publications

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology

Effects of noise exposure on young adults with normal audiograms I: Electrophysiology

Perceptual Consequences of “Hidden” Hearing Loss

Short-term music-induced hearing loss after sound exposure to discotheque music: The effectiveness of a break in reducing temporary threshold shift

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