A behavioral bioassay for analysis of rabbit nipple-search pheromone

Keil, W.; Stralendorff, F. v.; Hudson, Robyn

doi:10.1016/0031-9384(90)90120-s

Cited by 56 publications

(26 citation statements)

References 13 publications

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“…Our neuropathological studies support that oromotor dysfunction was related to supranuclear injury, because we failed to observe either acute or delayed injury to brainstem nuclei by TUNEL staining (data not shown). A more detailed study is needed to investigate the basis of such complex behavior that may be the summative response of many reflexes (Drewett et al, 1982;Keil et al, 1990;Kindermann et al, 1994). We also observed deficits in aversive head turning in response to noxious olfactory stimuli, such as peppermint or alcohol (data not shown), in the P1 survivors of hypoxia-ischemia.…”

Section: Nature Of the Hypertonic Motor Deficitsmentioning

confidence: 76%

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy?

Derrick¹,

Luo²,

Bregman³

et al. 2004

J. Neurosci.

194

264

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Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. Despite the enormous impact of CP, there is no animal model that reproduces the hypertonia and motor disturbances of this disorder. We report a rabbit model of in utero placental insufficiency, in which hypertonia is accompanied by marked abnormalities in motor control. Preterm fetuses (67-70% gestation) were subjected to sustained global hypoxia. The dams survived and gave spontaneous birth. At postnatal day 1, the pups that survived were subjected to a battery of neurobehavioral tests developed specifically for these animals, and the tests were videotaped and scored in a masked manner. Newborn pups of hypoxic groups displayed significant impairment in multiple tests of spontaneous locomotion, reflex motor activity, and the coordination of suck and swallow. Increased tone of the limbs at rest and with active flexion and extension were observed in the survivors of the preterm insult.Histopathological studies identified a distinct pattern of acute injury to subcortical motor pathways that involved the basal ganglia and thalamus. Persistent injury to the caudate putamen and thalamus at P1 was significantly correlated with hypertonic motor deficits in the hypoxic group. Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia.

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Section: Nature Of the Hypertonic Motor Deficitsmentioning

confidence: 76%

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy?

Derrick¹,

Luo²,

Bregman³

et al. 2004

J. Neurosci.

194

264

View full text Add to dashboard Cite

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“…To locate the nipples rapidly, pups rely on odour cues emitted on the surface of the females' abdomen and/or in milk (e.g. Schley, 1976;Hudson and Distel, 1983;Keil et al, 1990;Coureaud et al, 2001). These odour cues may be learned before birth (e.g.…”

Section: Introductionmentioning

confidence: 99%

The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability

Coureaud

Fortun-Lamothe

Langlois³

et al. 2007

Animal

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Newborn rabbits depend on a daily nursing interaction with the mother to gain milk and to survive. During this interaction, they localise and seize the nipples displaying a typical behaviour triggered by maternal odour cues. The mammary pheromone constitutes such a signal in domestic rabbits: it elicits sucking-related movements in more than 90% of the pups. However, some newborns remain unresponsive to the presentation of the pheromone, even pups apparently healthy and highly motivated to suck. The main goal of the present study was therefore to explore the link between the unresponsiveness of rabbit pups to the mammary pheromone and their growth and survival in breeding conditions. To that end, 293 newborns from 30 litters were tested for their head searching-oral grasping responses to the mammary pheromone on days 1 and 3, and their milk intake and mortality were followed up from days 1 to 21. It was hypothesised that unresponsive newborns would have subsequent difficulties in finding nipples, sucking and surviving. Early weight and success in milk intake were further considered as mediating factors in growth and viability. The results showed that pups that were unresponsive to the mammary pheromone on day 1 were less successful in gaining milk and had a higher rate of mortality than the responsive pups. However, this impact was modulated by the weight of pups: it appeared only in the lightest newborns. Moreover, this impact vanished on day 3. On the other hand, the pup weight and sucking success on days 1 to 3 strongly influenced viability and growth during the period extending from days 1 to 21. Taken together, the results show that the day-1 responsiveness of rabbit pups to the mammary pheromone can be considered as an indicator of individual viability in pups having a small weight (,48 g on day 1). The predictive validity of the pups' pheromonal reactivity seems however time-limited as it works only during the first, but crucial, postnatal days.

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“…Chemical cues releasing nipple-search behaviour and nipple grasping are present in the milk (Schley 1981;Keil et al 1990), and a compound in the milk releasing grasping, 2-methylbut-2-enal, has been recently identified (Schaal et al 2003;Moncomble et al 2005). However, it is still not clear if a single substance can account for the complete nipple-search sequence, nor how the cues come to be distributed on the doe's ventrum in such a way as to release the search behaviour and guide pups to nipples, and then even in non-lactating does Distel 1983, 1990;Distel and Hudson 1984;.…”

Section: Nursing and Sucklingmentioning

confidence: 97%

Mother-Young and Within-Litter Relations in the European Rabbit Oryctolagus cuniculus

2008

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A behavioral bioassay for analysis of rabbit nipple-search pheromone

Cited by 56 publications

References 13 publications

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy?

Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy?

The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability

Mother-Young and Within-Litter Relations in the European Rabbit Oryctolagus cuniculus

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