A behavioral and cognitive neuroscience perspective on impulsivity, suicide, and non-suicidal self-injury: Meta-analysis and recommendations for future research

Liu, Richard T.; Trout, Zoë M.; Hernandez, Evelyn M.; Cheek, Shayna M.; Gerlus, Nimesha

doi:10.1016/j.neubiorev.2017.09.019

Cited by 141 publications

(94 citation statements)

References 95 publications

(151 reference statements)

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“…Although suicide is most often associated with depression, impulsivity, or a lack of self-control has also been found to predict suicide attempts [107] though this relationship is under debate [108,109]. Teens who experienced earlier life stress report higher rates of impulsive behavior [110], and suicide rates among teens are higher than the general population [111].…”

Section: Mirnas In Els and Suicidal Behaviormentioning

confidence: 99%

MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior

2019

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Childhood environment can have a profound impact on brain structure and function. Epigenetic mechanisms have been shown to play a critical role in adaptive and maladaptive processes by regulating gene expression without changing the genome. Over the past few years, early life stress (ELS) has been established as a major risk factor for major depression and suicidal behavior along with other psychiatric illnesses in adulthood. In recent years, the emergence of small noncoding RNAs as a mega controller of gene expression has gained attention for their role in various disease processes. Among various noncoding RNAs, microRNAs (miRNAs) are the most studied and well characterized and have emerged as a major regulator of neural plasticity and higher brain functioning. More recently, although limited in number, studies are focusing on how miRNAs can play a role in the maladaptive processes associated with ELS both at adolescent and adult age and whether these processes are critical in developing depression and suicidal behavior. In this review, we critically evaluate how postnatal ELS relates to abnormalities in miRNA expression and functions from both animal and human literature and draw connections from these findings to depression and suicidal behavior later in life.

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Section: Mirnas In Els and Suicidal Behaviormentioning

confidence: 99%

MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior

2019

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“…While impulse behavior is a co-occurring behavior of the FASD diagnosed, FASD and impulsivity is not fully understood in relation to suicide. Indeed, studies on attempt impulsivity have produced widely divergent results, thus showing a need for prospective studies linking behavioral impulsivity (and co-occurring conditions) with non-suicidal and suicidal injury or means [80].…”

Section: Resultsmentioning

confidence: 99%

Reflecting back to move forward with suicide behavior estimation for First Nations in Canada

Elias¹

2019

SJI

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While many countries produce suicide rates, within country estimation practices may privilege the dominant society and fail to report suicide estimates for populations historically discriminated against. In Canada, national suicide mortality studies are rarely reported for Indigenous populations. Yet, this population is known for high suicide behavior. Administrative, census and survey data are available but are not systematically or critically analyzed. To address this gap, this paper provides an overview of social-political drivers to improve Indigenous statistics (particularly for suicide) and opportunities to report Indigenous suicide via different data sources in Canada. A case study illustrates the use of multiple data sources to report suicide and its correlates for an Indigenous group residing in the Province of Manitoba (Canada). Recommendations then follow to improve Indigenous statistics for suicide.

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“…19 Many studies have reported that impulsivity is associated with suicidal behavior. [20][21][22][23] One study showed that greater self-reported impulsivity was associated with more self-reported thoughts of suicide and self-harm. 24 Recently, one study reported that local atrophy of the left hippocampus, right caudate, and right pallidum had a positive correlation with impulsivity among major depressive disorder patients with suicidal ideation in comparison between MDD with suicidal ideation and without.…”

Section: The Relationship Between Performance Of Attention Task and Smentioning

confidence: 99%

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

Kim

Kong

2020

Psychiatry Investig

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Objective We examined the performance of attention tests related to suicidal ideation in mood disorder patients and to explain the difference of attention test performance in relation to suicidal ideation after controlling clinical and psychological variables of mood disorder patients.Methods Seventy-three in- and outpatients with major depressive disorder (n=41) or bipolar disorder (n=32) completed a self-rating questionnaire assessing socio-demographic characteristics, and clinical and psychological variables. Comprehensive Attention Test (CAT) also was conducted.Results Thirty-three patients were the high-suicidal ideation (SI) group, and forty patients were the low-SI group. The errors of commission (CEs) of visual sustained attention in the high-SI group was 6.3 times higher on average than that of the low-SI group. After controlling for sex, age, and diagnosis, a higher number of CEs on visual sustained attention tasks predicted higher SI score. However, after controlling for sex, age, diagnosis, and depressive mood, this predictive ability was no longer observed.Conclusion This study showed that CE on the visual sustained attention task seems to influence suicidal ideation as a result of interaction with depressive symptoms.

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A behavioral and cognitive neuroscience perspective on impulsivity, suicide, and non-suicidal self-injury: Meta-analysis and recommendations for future research

Cited by 141 publications

References 95 publications

MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior

MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior

Reflecting back to move forward with suicide behavior estimation for First Nations in Canada

The Relationship between Performance of Attention Task and Suicidal Ideation in Korean Patients with Mood Disorders

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