This thesis demonst rates a real time automated hybrid method for process monitoring. Motivation of this research comes from the fact that there is hardly any single techniques available which is decent enough for process fault detection and diagnosis simultaneously. Process history based methods are well known as early fault detectors but operators require complex analysis t o find out the root cause of the fault.Knowledge based qualitative models are worthy for root cause analysis but mostly done in off-line fashion. Moreover, modern processes are equipped with thousands of variables and structurally they are very complex in nature. All these influences make manual diagnostic task more complicated for the operators. T herefore, there is a need for automated process monitoring tool that has good detection and diagnosis performance.In this work, a hybrid method based on principal component analysis (P CA) and Bayesian belief network (BBN) is described for process monitoring. P CA is very profi cient as early faul t detector but not for faul t diagnosis. On the ot her hand , BBN is good for diagnosis. This hybrid method combines t he strong features of both P CA and BBN to an a utomated monitoring system that can detect fault early as well as diagnose the root cause precisely. Upon successful detection of fault from PCA, diagnostic information from t he P CA is passed to the BBN for root cause analysis.Pearl's message passing algorithm is used for belief updating. T his monitoring tool 11 integrates prior process knowledge along with the present observed evidence processed by the multivariate sta tistical method to come up with the most probable explanation of process fault. Efficacy of t he proposed method is verified by simulating different scenarios on a simulated dissolution tank model. The monitoring tool is also validated using indust rial data from a pure terephthalic acid (PTA) plant .iii Acknowledgements Foremost, I would like to express my sincere gratitude to my supervisor Dr. Syed A Imtiaz for all his generous help , support and valuable suggestions. Since the first day, he had been guiding me in this difficult voyage. There were t imes of frustration in research, when his patience, motivation, enthusiasm and immense knowledge provided me the right directions.