A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study

Angélico, M.; Nardi, Alessandra; Romagnoli, Renato; Marianelli, T.; Corradini, Stefano Ginanni; Tandoi, Francesco; Gavrila, C.; Salizzoni, Mauro; Pinna, Antonio Daniele; Cillo, Umberto; Gridelli, Bruno; Carlis, Luciano Gregorio De; Colledan, M.; Gerunda, G.E.; Costa, Alessandro Nanni; Strazzabosco, Mario

doi:10.1016/j.dld.2013.11.004

Cited by 19 publications

(24 citation statements)

References 27 publications

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“…This discrepancy can be in part explained by the fact that immune-competent women may lose their advantage over men once they reach the post-menopausal state, possibly due to a favourable role played by oestrogens in controlling known cofactors for HCV disease progression such as inflammation [15,16] and steatosis [17,18]. However, while the "male-like" faster fibrosis progression observed in post-LT females may be attributed to the hormonal changes associated with the menopausal state, the reason why women fare even worse than men after LT remains unclear.…”

Section: Discussionmentioning

confidence: 90%

Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort

Belli

Romagnoli

Nardi

et al. 2015

Digestive and Liver Disease

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Section: Discussionmentioning

confidence: 90%

Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort

Belli

Romagnoli

Nardi

et al. 2015

Digestive and Liver Disease

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“…Eight full text articles were excluded for lacking a DBD comparison group . Six studies did not report on IC or biliary outcomes and did not report absolute figures for graft and recipient survival so were excluded for lack of information . Two studies described uncontrolled DCD donor populations and one had an inadequate control group .…”

Section: Resultsmentioning

confidence: 99%

A meta-analysis and meta-regression of outcomes including biliary complications in donation after cardiac death liver transplantation

et al. 2014

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SummaryDonation after cardiac death (DCD) liver transplantation is increasingly common but concerns exist over the development of biliary complications and ischemic cholangiopathy (IC). This study aimed to compare outcomes between DCD and donation after brain death (DBD) liver grafts. Studies reporting on post-transplantation outcomes after Maastricht category III DCD liver transplantation were screened for inclusion. Odds ratios (OR) with 95% confidence intervals were produced using random-effects models for the incidence of biliary complications, IC, graft and recipient survival. Meta-regression was undertaken to identify betweenstudy predictors of effect size for biliary complications and IC. PROSPERO Record: CRD42012002113. Twenty-five studies with 62 184 liver transplant recipients (DCD = 2478 and DBD = 59 706) were included. In comparison with DBD, there was a significant increase in biliary complications [OR = 2.4 (1.9, 3.1); P < 0.00001] and IC [OR = 10.5 (5.7, 19.5); P < 0.00001] following DCD liver transplantation. In comparison with DBD, at 1 year [OR = 0.7 (0.5, 0.8); P = 0.0002] and 3 years [OR = 0.6 (0.5, 0.8); P = 0.001], there was a significant decrease in graft survival following DCD liver transplantation. At 1 year, there was also a nonsignificant decrease [OR = 0.8 (0.6, 1.0); P = 0.08] and by 3 years a significant decrease [OR = 0.7 (0.5, 1.0); P = 0.04] found in recipient survival following DCD liver transplantation. Eleven factors were entered into meta-regression models, but none explained the variability in effect size between studies. DCD liver transplantation is associated with an increase in biliary complications, IC, graft loss and mortality. Significant unexplained differences in effect size exist between centers.

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“…On the other hand, PVT did not emerge as a significant risk factor for early graft loss in the study by Angelico et al . on data from an Italian multicenter LT cohort (“Liver match”).…”

Section: Discussionmentioning

confidence: 99%

Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis

et al. 2018

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Portal vein thrombosis (PVT) is the most common thrombotic event in liver transplant (LT) recipients, but its impact on mortality after LT has been analyzed in heterogeneous cohorts with mixed results. To conduct a meta-analysis on the impact of PVT on post-LT survival. A systematic search was conducted on studies (published from January 1986 to January 2018) that reported 30-day and 1-year mortality after LT of PVT patients. Four hundred twenty-seven articles were reviewed and 44 were included. Among 98 558 LT, 7257 (7.3%) involved patients with PVT. The mean quality was high (7.1 on the Newcastle-Ottawa scale). The 30-day pooled mortality rate was higher for patients with PVT (64/490; 13%) than for others (259/3357; 7%) (OR 2.29; 95% CI 1.43-3.68; P < 0.0001). One-year mortality was likewise higher in recipients with (853/6302; 13.5%) than in those without PVT (7476/75 355; 9.9%) (OR 1.38; 95% CI 1.14-1.66; P < 0.0001). Heterogeneity wasn't significant (I 46% and 65%). Patients whose PVT was complete had a higher 30-day pooled mortality rate (OR 5.65; 95% CI 2-15.96; P < 0.0001), and a 1-year mortality rate (OR 2.48; 95% CI 0.99-6.17; P = 0.38) than patients with partial PVT. PVT is common in LT candidates and it is associated with higher short- and medium-term mortality after LT.

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A Bayesian methodology to improve prediction of early graft loss after liver transplantation derived from the Liver Match study

Cited by 19 publications

References 27 publications

Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort

Recipient female gender is a risk factor for graft loss after liver transplantation for chronic hepatitis C: Evidence from the prospective Liver Match cohort

A meta-analysis and meta-regression of outcomes including biliary complications in donation after cardiac death liver transplantation

Mortality in liver transplant recipients with portal vein thrombosis - an updated meta-analysis

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