A Bayesian Approach to Identifying New Risk Factors for Dementia

Wen, Yao-Ko; Wu, Shihn-Sheng; Lin, Chun-Hung Richard; Tsai, Jui‐Hsiu; Yang, Pinchen; Chang, Yang‐Pei; Tseng, Kuan-Hua

doi:10.1097/md.0000000000003658

Cited by 21 publications

(25 citation statements)

References 41 publications

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“…Twelve of the 17 studies (70.6%) included in this analysis were prospective cohort studies measuring hearing loss as a risk factor and some form of dementia as an outcome . Four of the 17 studies (23.5%) were cross‐sectional .…”

Section: Resultsmentioning

confidence: 99%

“…Twelve of the 17 studies (70.6%) included in this analysis were prospective cohort studies measuring hearing loss as a risk factor and some form of dementia as an outcome. 3,4,[13][14][15][16][17][18][19][20][21][22] Four of the 17 studies (23.5%) were cross-sectional. [23][24][25][26] Twelve of the studies followed participants living in the United States.…”

Section: Resultsmentioning

confidence: 99%

“…[23][24][25][26] Twelve of the studies followed participants living in the United States. Five took place in other localities: Italy (1/17), 24 Australia (1/17), 25 Germany (1/17), 26 Taiwan (1/17), 20 and Japan (1/17). 22 The number of participants ranged anywhere from 200 to 1,338,462.…”

Section: Resultsmentioning

confidence: 99%

“…4,19,21 Covariates Many studies controlled for potentially confounding variables such as diabetes, hypertension, smoking status, high cholesterol, and history of stroke or cerebrovascular disease. 4,13,[15][16][17][18][19][20]22,23,25,26 Some studies controlled for less commonly tested variables such as depression (7/ 17) 4,17,[20][21][22]27 and a genetic test indicating the presence of the APOE-e allele which has been identified as being associated with Alzheimer's Disease (AD) (1/17). 15…”

Section: Hearing Loss Ascertainmentmentioning

confidence: 99%

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Hearing loss as a risk factor for dementia: A systematic review

Thomson

Auduong

Miller

et al. 2017

Laryngoscope Investig Oto

262

189

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ObjectivesTo review evidence of hearing loss as a risk factor for dementia. Data Sources: PubMed Review methods: A systematic review was conducted using the PubMed database using the search terms (hearing loss OR presbycusis) AND (dementia OR cognitive decline). Initially, 488 articles were obtained. Only those studies evaluating an association between hearing loss and incident dementia or cognitive decline were included in the analysis. This resulted in 17 articles which were thoroughly evaluated with consideration for study design, method for determining hearing loss and cognitive status, relevant covariates and confounding factors, and key findings.ResultsAll of the 17 articles meeting inclusion criteria indicate that hearing loss is associated with dementia or cognitive decline. The methods used among the studies for ascertaining hearing loss and dementia were notably varied. For hearing loss, peripheral auditory function was tested far more than central auditory function. For peripheral audition, pure tone audiometry was the most commonly reported method for defining hearing loss. Only a few studies measured central auditory function by using the Synthetic Sentence Identification with Ipsilateral Competing Message test (SSI‐ICM) and the Staggered Spondaic Word Test (SSW). Dementia was most often defined using the Mini Mental State Exam (MMSE). However, many studies used extensive batteries of tests to define cognitive status, often including a neuropsychologist. Confounding variables such as cardiovascular risk factors were measured in 17 studies and family history of dementia was only evaluated in 1 study. Overall, the methods used by studies to ascertain hearing loss, cognitive status and other variables are valid, making their evaluation appear reliable.ConclusionWhile each of the studies included in this study utilized slightly different methods for evaluating participants, each of them demonstrated that hearing loss is associated with higher incidence of dementia in older adults.Level of EvidenceLevel V, systematic review.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Hearing Loss Ascertainmentmentioning

confidence: 99%

See 2 more Smart Citations

Hearing loss as a risk factor for dementia: A systematic review

Thomson

Auduong

Miller

et al. 2017

Laryngoscope Investig Oto

262

189

View full text Add to dashboard Cite

show abstract

“…VD is one of the most common types of senile dementia, second only to Alzheimer's disease, accounting for about 10–50% of patients with dementia (8). With an ever increasing aging population and increasing incidence of cardiovascular and cerebrovascular diseases, the incidence of VD may become the most common type of dementia (9).…”

Section: Discussionmentioning

confidence: 99%

Expression of S100β protein in patients with vascular dementia after basal ganglia hemorrhage and its clinical significance

Shu

Wang

Zhang

et al. 2017

Experimental and Therapeutic Medicine

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We investigated the expression levels and clinical significance of S100β protein in patients with vascular dementia (VD) after basal ganglia hemorrhage. From June 2014 to December 2015, in 138 patients with basal ganglia hemorrhage, we carried out the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in patients on the day before the operation, the day after the operation and 9 days after the operation. Thirty-two patients (blood vessel group) had cognitive dysfunction and 106 patients (control group) had VD. One hundred thirty-eight cases of healthy adult volunteers were treated in Henan Provincial People's Hospital and were selected in the same period as healthy controls. The expression levels of serum S100β in the three groups were tested through the ELISA method and the statistical analysis was carried out. In VD patients, the serum S100β levels of patients were significantly higher than VD and healthy control groups; differences were statistically significant (P<0.05). However, there was no significant difference between those without VD after operation and the healthy control group (P>0.05). The correlation analysis was carried out with serum S100β as an independent variable and mean arterial pressure, BMI, MMSE and MoCA scores as dependent variables. Our results suggest that S100β expression levels were negatively correlated to the MMSE score (rs=−4.19) and the difference was statistically significant (P<0.05). The length of hospital stay of patients with basal ganglia hemorrhage associated with VD was significantly extended, with a mean of 23.4±2.8 days. The expression levels of S100β protein in the serum of patients with VD after basal ganglia hemorrhage was significantly increased and negatively correlated to the cognitive function of patients. Therefore, it can be used as a differential diagnosis indicator of VD after the basal ganglia hemorrhage and treatment target point of the VD.

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