A basic smell test is as sensitive as a dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson's disease

Deeb, Janina Golob; Shah, Mussadiq; Muhammed, Nizar; Gunasekera, Ranjan; Gannon, Kenneth N.; Findley, Leslie J.; Hawkes, Chris

doi:10.1093/qjmed/hcq142

Cited by 96 publications

(127 citation statements)

References 41 publications

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“…According to this study, olfactory testing can successfully distinguish PD patients from Non-parkinsonism, which is in line with previous studies [22][23][24][25]. However, olfactory testing fails in distinguishing PD from APS or APS from Non-parkinsonism.…”

Section: Olfactionsupporting

confidence: 91%

“…However, its specificity was poor (40%) in both cases. These results are comparable to Deeb et al [22] , but not in accordance with other studies where sensitivity and specificity were nearly on the same level [25,30]. A potential explanation for this divergence could depend on cultural biases and odour familiarity.…”

Section: Olfactionsupporting

confidence: 77%

“…Compared to the B-SIT test, the visual assessment of DaTSCAN was more efficient in discriminating parkinsonism from Non-parkinsonism in terms of sensitivity (96%), specificity (80%) and diagnostic accuracy (92%). These results contradict Deeb et al, who suggested that a basic smell test is as sensitive as DaTSCAN [22], but are in accordance with Hong et al who, by comparing the Cross-Cultural Smell Identification Test and dopamine transporter Positron Emission Tomography (PET), proved that the olfactory test alone has little power in detecting dopaminergic depletion [33].…”

Section: Datscancontrasting

confidence: 54%

“…The aforementioned studies by Deeb et al [22]. and Hong et al [33] also found strong correlation between the score of smell identification test and the DaTSCAN uptake in PD patients.…”

Section: Datscanmentioning

confidence: 80%

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The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

et al. 2015

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The aim of the study was to compare the efficacy of olfactory testing and presynaptic dopamine imaging in diagnosing Parkinsons disease (PD) and atypical parkinsonian syndromes (APS); to evaluate if the combination of these two diagnostic tools can improve their diagnostic value. A prospective investigation of 24 PD patients, 16 APS patients and 15 patients with non-parkinsonian syndromes was performed during an 18-month period. Single photon emission computed tomography with the presynaptic radioligand I-123-FP-CIT (DaTSCAN (R)) and olfactory testing with the Brief 12-item Smell Identification Test (B-SIT) were performed in all patients. DaTSCAN was analysed semi-quantitatively, by calculating two different striatal uptake ratios, and visually according to a predefined ranking scale. B-SIT score was significantly lower for PD patients, but not significantly different between APS and non-parkinsonism. The visual assessment of DaTSCAN had higher sensitivity, specificity and diagnostic accuracy compared to olfactory testing. Most PD patients (75 %) had visually predominant dopamine depletion in putamen, while most APS patients (56 %) had visually severe dopamine depletion both in putamen and in caudate nucleus. The combination of DaTSCAN and B-SIT led to a higher rate of correctly classified patients. Olfactory testing can distinguish PD from non-parkinsonism, but not PD from APS or APS from non-parkinsonism. DaTSCAN is more efficient than olfactory testing and can be valuable in differentiating PD from APS. However, combining olfactory testing and DaTSCAN imaging has a higher predictive value than these two methods separately.

Funding Agencies|Ostergotland County Council (ALF); Swedish Parkinsons Foundation

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Section: Olfactionsupporting

confidence: 91%

Section: Olfactionsupporting

confidence: 77%

Section: Datscancontrasting

confidence: 54%

“…The aforementioned studies by Deeb et al [22]. and Hong et al [33] also found strong correlation between the score of smell identification test and the DaTSCAN uptake in PD patients.…”

Section: Datscanmentioning

confidence: 80%

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The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

et al. 2015

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Funding Agencies|Ostergotland County Council (ALF); Swedish Parkinsons Foundation

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“…They make it possible to differentiate between persons suffering from PD and healthy individuals as well as to differentiate between various Parkinson's syndromes more accurately than in the case of the motor function [52]. The sensitivity and specificity of the olfactory function tests is in this regard higher than in the case of other diagnostic methods such as PET and SPECT imaging [53]. The inclusion of the olfactory function evaluation increased the accuracy of the PD diagnosis to 90% [15].…”

Section: Differential Diagnosis Of Parkinson's Syndromes Based On Thementioning

confidence: 99%

Olfactory dysfunctions occurring in the course of Parkinson’s disease

Śmigórski¹,

Śmigórska²

2017

ppn

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Purpose: The aim of this article is to provide a summary of findings concerning the olfactory loss associated with pathological neuro degenerative changes which occur in the course of Parkinson's disease. Views: Olfactory function deficits occur in the early, prodromal stage of Parkinson's disease and their severity is much higher, especially compared with other neurodegenerative diseases. Information on characteristics of olfactory loss in Parkinson's disease is presented in the article. Conclusions: Authors indicate that olfactory function assessment is useful in differential diagnosis of neurodegenerative disorders in their prodromal stage and physiological aging. Olfactory ability evaluation may be also very helpful in differential diagnosis of parkinsonism syndromes. Severity of the olfactory impairment may be a good predictor of neuropsychiatric complications de velopment in Parkinson's disease. Key words: Parkinson's disease, olfaction disorders, olfactory perception, dementia, smell. StreszczenieCel: Celem artykułu jest przedstawienie stanu wiedzy na temat utraty sprawności węchowej związanej z patologicznymi zmianami neurozwyrodnieniowymi zachodzącymi w przebiegu choroby Parkinsona. Poglądy: Zaburzenia sprawności węchowej pojawiają się we wczesnym, prodromalnym etapie rozwoju choroby Parkinsona, a ich natężenie jest większe niż w innych chorobach neurozwyrodnieniowych. W artykule przedstawiono informacje na temat charakte rystyki utraty węchu w chorobie Parkinsona.Wnioski: Autorzy wykazują, że ocena sprawności węchowej jest użyteczna w różnicowaniu zaburzeń neurozwyrodnieniowych w ich prodromalnym stadium z fizjologicznym starzeniem się. Ewaluacja sprawności węchowej może być również bardzo pomocna w róż nicowaniu diagnostycznym zespołów parkinsonowskich. Głębokość zaburzeń węchowych może być dobrym predyktorem rozwoju zaburzeń neuropsychiatrycznych w chorobie Parkinsona. Słowa kluczowe: choroba Parkinsona, zaburzenia węchu, percepcja węchowa, otępienie, węch.

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The Sense of Smell in Our Lives

Sell¹

2014

Chemistry and the Sense of Smell

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A basic smell test is as sensitive as a dopamine transporter scan: comparison of olfaction, taste and DaTSCAN in the diagnosis of Parkinson's disease

Cited by 96 publications

References 41 publications

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

The diagnostic value of dopamine transporter imaging and olfactory testing in patients with parkinsonian syndromes

Olfactory dysfunctions occurring in the course of Parkinson’s disease

The Sense of Smell in Our Lives

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