A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018

Chahine, Elias B.; Durham, Spencer H.; Mediwala, Krutika N; Chastain, Daniel B; Gauthier, Timothy P.; Hill, Brandon; Jones, Bruce M; Kisgen, Jamie; Marx, Ashley; Stover, Kayla R.; Worley, Marylee V.; Bland, Christopher M.; Bookstaver, P Brandon

doi:10.1093/ofid/ofz450

Cited by 7 publications

(1 citation statement)

References 42 publications

(35 reference statements)

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“…AMS interventions improve antibiotic use through education, audits of antibiotics, and feedback to providers [29]. There is little literature from SSA on AMS interventions; however, one study from South Africa revealed that AMS can be implemented in that context and have significant impacts in decreasing days of antibiotic consumption [30].…”

Section: Discussionmentioning

confidence: 99%

Antibiogram Development in the Setting of a High Frequency of Multi-Drug Resistant Organisms at University Teaching Hospital, Lusaka, Zambia

et al. 2021

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Antimicrobial resistance is a global challenge requiring reliable surveillance data collection and use. Prior studies on resistance in Zambia depended on laboratory methods with limited standardization. Since 2015, the University Teaching Hospital (UTH) microbiology laboratory has used the Vitek 2 Compact (bioMerieux, Inc., Marcy-l’Étoile, France) for standardized identification and susceptibility testing. We conducted a cross-sectional study of 2019 bacterial isolates collected from July 2015 to April 2017 to identify bacterial causes of infections, their susceptibility to commonly used antibiotics at UTH, and develop hospital antibiograms with a multidisciplinary team using World Health Organization guidance. We found high levels of antibiotic resistance among Gram negative bacteria. Escherichia coli and Klebsiella pneumoniae were highly resistant to all antibiotics except amikacin and carbapenems. E. coli had susceptibilities of 42.4% to amoxicillin/clavulanic acid, 41.4% to ceftriaxone, 40.2% to ciprofloxacin, and 10.4% to trimethoprim/sulfamethoxazole (TMP/SMX). K. pneumoniae had susceptibilities of 20.7% to amoxicillin/clavulanic acid, 15.6% to ceftriaxone, 48.5% to ciprofloxacin, and 12.3% to TMP/SMX. The high resistance to 3rd generation cephalosporins indicates high rates of beta-lactamase production. This is information that clinicians need to inform clinical decision making and choice of empiric antibiotics and that UTH requires to inform antimicrobial stewardship such as improvements in antibiotic use.

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Section: Discussionmentioning

confidence: 99%

Antibiogram Development in the Setting of a High Frequency of Multi-Drug Resistant Organisms at University Teaching Hospital, Lusaka, Zambia

et al. 2021

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Antimicrobial Stewardship: Knowing Why, Seeking How

Olans¹,

Olans²

2020

The Joint Commission Journal on Quality and Patient Safety

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A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2019

Stover

Chahine

Cluck

et al. 2020

Open Forum Infectious Diseases

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Staying current on literature related to antimicrobial stewardship can be challenging given the ever-increasing number of published articles. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2019. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training as well as to identify potential intervention opportunities within one’s institution

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A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018

Cited by 7 publications

References 42 publications

Antibiogram Development in the Setting of a High Frequency of Multi-Drug Resistant Organisms at University Teaching Hospital, Lusaka, Zambia

Antibiogram Development in the Setting of a High Frequency of Multi-Drug Resistant Organisms at University Teaching Hospital, Lusaka, Zambia

Antimicrobial Stewardship: Knowing Why, Seeking How

A Baker’s Dozen of Top Antimicrobial Stewardship Intervention Publications in 2019

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