A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds

Deepa, D; Chaudhuri, Aiswarya; Kumar, Dulla Naveen; Patil, Rohit; Gangwar, Mayank; Rastogi, Shishir; Kumar, Dinesh; Nath, Gopal; Agrawal, Ashish Kumar

doi:10.3390/ph16070942

Pharmaceuticals

2023

DOI: 10.3390/ph16070942

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A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds

D Deepa

Aiswarya Chaudhuri

Dulla Naveen Kumar

et al.

Abstract: Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is one of the major pathogens present in burn wound infections. Biofilm formation makes it further challenging to treat with clinically available antibiotics. In the current work, we isolated the A. baumannii-specific bacteriophages (BPABΦ1), loaded into the chitosan microparticles followed by dispersion in gel, and evaluated therapeutic efficacy against MDR A. baumannii clinical strains. Isolated BPABΦ1 were found to belong to the Corticoviridae… Show more

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2024

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Cited by 3 publications

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Phage therapy: an alternative treatment modality for MDR bacterial infections

Pal,

Sharma,

Kumawat

et al. 2024

Infectious Diseases

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Phage therapy: an alternative treatment modality for MDR bacterial infections

Pal,

Sharma,

Kumawat

et al. 2024

Infectious Diseases

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Modern views on the microflora of burn wounds and its antibiotic resistance

Zurnadzh’yants,

Kchibekov,

Mel’nikova

et al. 2024

jour

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Prognosis of outcome of the burn injury depends on recovery speed of damaged layers of derma, therefore execution of the authodermoplasty stays the main principle of the burn injury treatment. However, local infectious complication retard processes of reparation and epithelization of tissues, hinder the engraftment of the donor skin graft, promote the lasting of healing of the donor wounds. But penetration of pathogenic microflora via damaged skin covers leads to infectious generalization with development of multiple organ failure, sepsis, pneumonia, to the increase of lethal outcome quantity. Considering the role of infection in a structure of mortality of burned patients, the significance to study of its etiology, pathogenesis and treatment does not raise doubts. Opportunistic microflora, causing hospital-acquired, or nosocomial, infections, plays a great role in the development of the similar condition in severely burned patients. Among these representatives are Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii and Enterobacteriaceae spp. The main clinical significant characteristics of such flora are multiresistance to most antimicrobial drugs, high prevalence in hospitals, and the ability to form biofilms on the surface of burn wounds. It should be noted that with every year the trend of antimicrobial resistance is increasing, and the number of resistant strains is also increasing. Therefore, it is getting more difficult to select adequate antibacterial treatment schemes for severe complicated burn injuries. The prescription of empirical therapy for nosocomial infections in burn patients should be based on the results of monitoring the microbial flora and determining its sensitivity to antibacterial drugs. In addition, methods of local treatment of wounds are constantly being improved using special wound dressings with antiseptic solutions and bacteriophage. To improve treatment rates for such patients, it is necessary to evaluate not only the local state of the wound surface, the degree of bacterial contamination of wounds and systemic inflammation during the entire period of hospitalization, but also the state of the epidemiological situation in burn care hospitals.

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Designing a Novel Multi-epitope Peptide as a Potential Serodiagnosis Marker for the Diagnosis of Acinetobacter baumannii: An In silico Approach

Rezaee,

Mohammadi,

Savardashtaki

et al. 2024

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Background: Acinetobacter baumannii is an opportunistic pathogen that causes many infections, including nosocomial infections; this bacterium has a high mortality rate among other bacteria. A. baumannii has an elastic genome that changes rapidly when exposed to harsh environmental conditions, leading to widespread bacterial resistance to various disinfectants and antibiotics. The high ability of bacteria to bind to all surfaces and survive in different conditions has caused the spread of bacteria in various environments. Rapid detection is very important in preventing the spread and even treatment of the infection. Methods: Currently, the Polymerase Chain Reaction (PCR) method is the only effective method used for diagnosis, which has some pros and cons. Results and Conclusion: This study aimed to design a new recombinant multi-epitope protein from Acinetobacter baumannii that can be used in ELISA for rapid diagnosis. The unique feature of this study from others is the use of patient serum for antibody monitoring.

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A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds

Cited by 3 publications

References 52 publications

Phage therapy: an alternative treatment modality for MDR bacterial infections

Phage therapy: an alternative treatment modality for MDR bacterial infections

Modern views on the microflora of burn wounds and its antibiotic resistance

Designing a Novel Multi-epitope Peptide as a Potential Serodiagnosis Marker for the Diagnosis of Acinetobacter baumannii: An In silico Approach

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