A bacteriological study of perforated duodenal ulcers

Shinagawa, N; Muramoto, Masayuki; Sakurai, Satoshi; Fukui, Takuji; Hori, Keiichi; Taniguchi, Masaaki; Mashita, Keiji; Mizuno, Akira; Yura, Jiro

doi:10.1007/bf02470859

Cited by 16 publications

(9 citation statements)

References 10 publications

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“…The reported rate of anaerobic infection peritonitis from ranges from 5.5% to 7.1%. 2,6,7 The higher isolation rate in our population may be attributed to the adoption of the following techniques. We aspirated peritoneal fluid before starting antibiotics, used appropriate transport medium for anaerobes (RCM) and incubation at 37°C in all cases.…”

Section: Discussionmentioning

confidence: 91%

“…In accordance with the trends seen in the previous studies in our institute, our study also documented that nearly 50% of the PPU patients belonged to the 30-50 years age group highlighting the socio-economic impact of this condition. [5][6][7] Male to female ratio in this series was 9.2: 1. There is a wide variation in the gender distribution reported in literature in different studies.…”

Section: Discussionmentioning

confidence: 92%

“…Isolates from gastro-duodenal perforations are predominantly aerobes in most cases. 6 However, previous studies have documented presence of anaerobes in PPU. 6,7 There is a paucity of data both from India and abroad, on this topic.…”

Section: Introductionmentioning

confidence: 95%

“…6 However, previous studies have documented presence of anaerobes in PPU. 6,7 There is a paucity of data both from India and abroad, on this topic. Hence this study was conducted to determine the clinico-microbiological profile of PPU with special reference to anaerobic bacteria.…”

Section: Introductionmentioning

confidence: 95%

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A clinico-microbiological profile in patients with perforated peptic ulcer with special reference to anaerobic organisms: a descriptive study

et al. 2017

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

A clinico-microbiological profile in patients with perforated peptic ulcer with special reference to anaerobic organisms: a descriptive study

et al. 2017

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“…3,4 While CECT scan remains the most widely used imaging technique for preoperative assessment, its sensitivity for detecting the peritoneal metastasis has been found to be low. 5,6 Diagnostic laparoscopy has been found to be effective in detecting this unsuspected peritoneal metastasis and avoid unnecessary laparotomies in recent studies. Hence the study was conducted to compare the efficacy of CECT and diagnostic laparoscopy in detecting unsuspected peritoneal metastasis in gastric carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of contrast enhanced computed tomography and diagnostic laparoscopy in detecting unsuspected peritoneal metastasis in gastric carcinoma

et al. 2017

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INTRODUCTIONGastric cancer remains the second most common cause of death from cancer worldwide.1,2 Peritoneal metastasis is the most frequent pattern of disease failure after curative resection of gastric cancer.3,4 Detection of these deposits and free cancer cells are necessary for predicting the risk of recurrence and prognostication. 3,4 While CECT scan remains the most widely used imaging technique for preoperative assessment, its sensitivity for detecting the peritoneal metastasis has been found to be low. 5,6 Diagnostic laparoscopy has been found to be effective in detecting this unsuspected peritoneal metastasis and avoid unnecessary laparotomies in recent studies. Hence the study was conducted to compare the efficacy of CECT and diagnostic laparoscopy in detecting unsuspected peritoneal metastasis in gastric carcinoma. ABSTRACTBackground: Gastric cancer remains the second most common cause of death from cancer worldwide. Peritoneal metastasis is the most frequent pattern of disease failure after curative resection of gastric cancer. Detection of these deposits and free cancer cells are necessary for predicting the risk of recurrence and prognostication. Methods: The study was conducted in Department of Surgery from October 2011 to July 2013. The study was designed as a prospective comparative study. All the patients diagnosed with gastric cancer by upper gastrointestinal endoscopy guided biopsy and not having clinical and / or radiological evidence of distant metastasis were included in the study. All patients underwent contrast enhanced computed tomography pre-operatively to detect metastatic disease or advanced gastric cancer. Subsequently the patients were planned for diagnostic laparoscopy followed by appropriate surgery. Sensitivities of the procedure in detecting peritoneal metastases was calculated and compared. Results: A total of 35 gastric cancer patients who met the inclusion and exclusion criteria were recruited in the study. The mean age of these patients was 53.5 years. Diagnostic laparoscopy detected 11 cases of metastatic diseases which were not picked up by CECT, which was statistically significant (p <0.05). Diagnostic laparoscopy showed adjacent organ infiltration in 18 patients, 9 of which were also identified on CT scan. Difference in detection of adjacent organ infiltration was not statistically significant. Infiltration of the serosal surface was seen in 31 patients and 9 of them were identified on CECT scan. Conclusions: Diagnostic laparoscopy is more sensitive and specific than current generation MDCT in detecting peritoneal metastasis and liver surface nodules in cases of gastric cancer. Diagnostic laparoscopy is also more specific in diagnosing the local infiltration into adjacent organs.

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Risk factors influencing the short-term results of gastroduodenal perforation

et al. 1994

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The purpose of this study was to evaluate the risk factors influencing the short-term results of gastroduodenal perforation to determine the optimal treatment for reducing mortality. A total of 136 patients were retrospectively reviewed and the prognostic factors were examined. Seven patients died within 30 days, with an overall mortality rate of 5.1%. Mortality was significantly worse in those aged 50 years or more, when the leukocyte count was less than 9,500/mm3, when treatment was delayed more than 12h after perforation, in cases of preoperative shock and renal failure, and when associated with liver cirrhosis or an immunocompromised state. Tolerance to the time delay was inversely proportional to age, while the deaths in patients aged 65 years or younger were related to serious concurrent diseases. Shock and renal failure occurred most often in elderly patients as a result of delayed surgery, and the leukocyte count was an age-dependent prognostic indicator. Thus, age, the time interval between perforation and treatment, serious concurrent disease, shock, and renal failure were presumed to be the most important prognostic factors. Although definitive operations were performed on low-risk patients with an acceptably low mortality, it remains to be determined whether simpler procedures should be adopted for high-risk patients.

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A bacteriological study of perforated duodenal ulcers

Cited by 16 publications

References 10 publications

A clinico-microbiological profile in patients with perforated peptic ulcer with special reference to anaerobic organisms: a descriptive study

A clinico-microbiological profile in patients with perforated peptic ulcer with special reference to anaerobic organisms: a descriptive study

Efficacy of contrast enhanced computed tomography and diagnostic laparoscopy in detecting unsuspected peritoneal metastasis in gastric carcinoma

Risk factors influencing the short-term results of gastroduodenal perforation

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