A bacteria-resistant and self-healing spray dressing based on lyotropic liquid crystals to treat infected post-operative wounds

Abstract

The delayed healing of infected post-operative wounds had turned into a worldwide medical problem. In the clinical treatment, effective bacterial clearance and promoted wound healing were considered as two crucial...

Graphene quantum dot doped viscoelastic lyotropic liquid crystal nanocolloids for antibacterial applications

“…78,79 The liquid viscoelastic and gel-like nature/behavior of LLCs & LLC nanocolloids make them potential candidates for microbial and pharmaceutical applications. 78,80,81 The microbial behavior of these systems is presented in the subsequent section.…”

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

“…LCCs have received attention for their potential as carriers of active molecules, both hydrophilic and hydrophobic, with controlled delivery [46,47]. However, their application as a spray wound dressing has been evaluated only recently [48][49][50]. For spray wound dressings, systems based on monooleins (GMO) were used, which present a phase transition when the water content is increased.…”

“…AMPs attract attention for having a wide range of action against gram-positive and gram-negative bacteria, fungi, viruses, and unicellular protozoa [79]. Because they also act fast and against resistant strains, AMPs have also been incorporated into spray-dressing formulations [37,38,48,59]. Furthermore, Annabi et al [38] demonstrated that the AMP Tet213 conjugated with a GelMA/MeTro hydrogel had a similar action to ZnO nanoparticles at 30-fold lower concentrations.…”

Emulsion Template Fabrication of Antibacterial Gelatin-Based Scaffolds with a Preferred Microstructure for Accelerated Wound Healing

“…Skin is the biggest organ in human beings and acts as the first barrier of the body. − Skin with multiple functions can maintain the internal microenvironment and resist external injuries, including harmful microorganisms, extreme temperature, mechanical injury, toxic substances, and radiation. , Once the skin barrier is damaged, it is difficult for injured skin to be rapidly completely repaired due to body dehydration, electrolyte loss, and pathogen invasion . Moreover, abnormal wound repair will be induced by the impact of various factors, including diabetes, large-area injuries caused by accident or burns, and infection .…”

“…4,5 Once the skin barrier is damaged, it is difficult for injured skin to be rapidly completely repaired due to body dehydration, electrolyte loss, and pathogen invasion. 6 Moreover, abnormal wound repair will be induced by the impact of various factors, including diabetes, 7 large-area injuries caused by accident 8 or burns, 9 and infection. 10 Compromised wound healing can lead to a great risk of chronic wounds and even death.…”