A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats

Song, Hai; He, Xiaoyun; Zou, Shiying; Zhang, Teng; Luo, Yunbo; Huang, Kunlun; Zhu, Zhen; Xu, Wentao

doi:10.1007/s11248-014-9844-6

Cited by 19 publications

(15 citation statements)

References 56 publications

(56 reference statements)

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“…Although the reports do not indicate direct risks to human and animal health, when the details of all the reports are considered, certain effects were observed, such as statistically significant differences in clinical performance of SD rats in response to consumption of high amylose and resistant GM-rice (Zhou et al 2011). Song et al (2015) concluded that biochemical and hematological blood parameters were comparable when SD rats were fed with Bt transgenic rice (expressing cry1Ab). Broiler chickens fed with GM soybean (expressing an imidazolinone tolerance gene) had lower body weight in comparison to the controls.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

Tsatsakis

Nawaz

Tutelyan

et al. 2017

Food and Chemical Toxicology

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Modern agriculture provides the potential for sustainable feeding of the world's increasing population. Up to the present moment, genetically modified (GM) products have enabled increased yields and reduced pesticide usage. Nevertheless, GM products are controversial amongst policy makers, scientists and the consumers, regarding their possible environmental, ecological, and health risks. Scientific-and-political debates can even influence legislation and prospective risk assessment procedure. Currently, the scientifically-assessed direct hazardous impacts of GM food and feed on fauna and flora are conflicting; indeed, a review of literature available data provides some evidence of GM environmental and health risks. Although the consequences of gene flow and risks to biodiversity are debatable. Risks to the environment and ecosystems can exist, such as the evolution of weed herbicide resistance during GM cultivation. A matter of high importance is to provide precise knowledge and adequate current information to regulatory agencies, governments, policy makers, researchers, and commercial GMO-releasing companies to enable them to thoroughly investigate the possible risks.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

Tsatsakis

Nawaz

Tutelyan

et al. 2017

Food and Chemical Toxicology

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“…The 90-day feeding study in rats has a unique advantage in the evaluation of GE food safety. Rats have been widely used for safety assessment of GE food, particularly for food from GE crops [21–23]. Rats also have been used as a model for safety evaluation of meat derived from GE animals.…”

Section: Introductionmentioning

confidence: 99%

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

et al. 2016

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Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. To assess any potential subchronic toxicity risks of this GE pork, a 90-day feeding study was conducted in Sprague-Dawley rats. Rats were randomly divided into five groups, and fed for 90 days with basic diet and basic diets formulated with low dose and high dose pork prepared from wild type pigs and GE pigs, respectively. Animal behaviors and clinical signs were monitored twice daily, and body weight and food consumption were measured and recorded weekly. At days 45 and 90, blood tests (lipid panel, electrolytes, parameters related to liver and kidney functions, and complete blood counts) were performed. Additionally, gross pathology and histopathological analyses were performed for major organs in each group. Data analysis shows that there were no significant differences in growth rate, food consumption, and blood test parameters between rat groups fed with GE pork and wild type pork. Although differences in some liver function parameters (such as aspartate aminotransferase, total proteins, albumin, and alkaline phosphatase) and white blood cell counts (such as lymphocyte percentage and monocyte percentage) were observed between rats fed with high dose GE pork and basic diet, all test results in rats fed with GE pork are in the normal range. Additionally, there are no apparent lesions noted in all organs isolated from rats in all five feeding groups on days 45 and 90. Overall, our results clearly indicate that food consumption of GE pork produced by ZFN-edited myostatin loss-of-function mutant pigs did not have any long-term adverse effects on the health status in rats.

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“…Otros estudios similares en ratas y pollos alimentados con arroz transgénico informan sobre alteraciones clínicas en parámetros hematológicos y en el peso de los animales (Zhou et al 2011;Song et al 2015).…”

Section: Resultados Y Discusiónunclassified

Alimentos Transgénicos: ¿sí O No? La Perspectiva Sudamericana

et al. 2019

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En 1983, después de una década de investigaciones en ingeniería genética, se creó la primera planta transgénica de tabaco. Unos diez años después se aprobó la introducción de plantas transgénicas en la producción agrícola, iniciándose una vertiginosa carrera ascendente en la presencia de los organismos genéticamente modificados (OGMs) en la agricultura. Sin embargo, hasta hoy se mantiene una álgida controversia entre los que, por un lado, defienden la inocuidad de los alimentos transgénicos y los que, en el extremo opuesto, se oponen tajantemente a su consumo. El debate ha conducido a que muchos países hayan legislado sobre el uso de los cultivos transgénicos y los alimentos resultantes. Los objetivos de este artículo fueron analizar el posible riesgo de los alimentos transgénicos y el estado en que se encuentran las legislaciones sobre ellos en Sudamérica. Se realizó una investigación documental sobre los riesgos de los alimentos obtenidos a partir de OGMs y las legislaciones vigentes en el subcontinente. El estudio permitió definir que aunque no se han informado afectaciones de los alimentos transgénicos a la salud humana, los datos no son concluyentes. Existen legislaciones en varios países sudamericanos, pero su perdurabilidad no está garantizada, lo que podría acarrear perjuicio a los consumidores.

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A 90-day subchronic feeding study of genetically modified rice expressing Cry1Ab protein in Sprague–Dawley rats

Cited by 19 publications

References 56 publications

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

Impact on environment, ecosystem, diversity and health from culturing and using GMOs as feed and food

A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork

Alimentos Transgénicos: ¿sí O No? La Perspectiva Sudamericana

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