A 9-Year-Old Boy with Multifocal Encephalomalacia: EEG Loreta and Lifespan Database, Magnetic Resonance Imaging and Neuropsychological Agreement

Cannon, Rex; Crane, Monica K.; Campbell, Paul D.; Dougherty, John H.; Baldwin, Debora R.; Effler, Joel D.; Phillips, Lisa S.; Hare, Felicia; Zachary, Matthew; Cox, Kelli E.; Loreto, Dominic J. Di

doi:10.1080/10874208.2011.545752

Cited by 6 publications

(2 citation statements)

References 62 publications

(59 reference statements)

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“…LORETA partitions the solution space into 2,394 cubic “voxels” (voxel dimension: 7 mm 3 ) limited to cortical gray matter and hippocampi, according to the digitized MNI probability atlases available from the Montreal Neurologic Institute (MNI; Montreal, Quebec, Canada). This distributed source localization technique has received cross-modal validation from studies combining LORETA with functional MRI (fMRI) (Mulert et al, 2004; Vitacco et al, 2002), structural MRI (Cannon et al, 2011; Worrell et al, 2000), intracranial EEG recordings (Zumsteg et al, 2006) and PET (Pizzagalli et al, 2004; Zumsteg et al, 2005; but see Gamma et al, 2004). Given that prior research has implicated theta current density in the rACC as a predictor of treatment response to antidepressant medication (Korb et al, 2009; Mulert et al, 2007; Pizzagalli et al, 2001; Rentzsch et al, 2014), analyses were restricted to this band (6.5–8 Hz) and a predefined rACC region-of-interest involving 13 voxels (Korb et al, 2009; Pizzagalli et al, 2001).…”

Section: Methodsmentioning

confidence: 99%

Demonstrating test‐retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response

et al. 2016

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Growing evidence suggests that loudness dependency of auditory evoked potentials (LDAEP) and resting EEG alpha and theta may be biological markers for predicting response to antidepressants. In spite of this promise, little is known about the joint reliability of these markers, and thus their clinical applicability. New, standardized procedures were developed to improve the compatibility of data acquired with different EEG platforms, and used to examine test-retest reliability for the three electrophysiological measures selected for a multisite project—Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). Thirty nine healthy controls across four clinical research sites were tested in two sessions separated by about one week. Resting EEG (eyes-open and eyes-closed conditions) was recorded and LDAEP measured using binaural tones (1000 Hz, 40 ms) at five intensities (60–100 dB SPL). Principal components analysis (PCA) of current source density (CSD) waveforms reduced volume conduction and provided reference-free measures of resting EEG alpha and N1 dipole activity to tones from auditory cortex. Low Resolution Electromagnetic Tomography (LORETA) extracted resting theta current density measures corresponding to rostral anterior cingulate (rACC), which has been implicated in treatment response. There were no significant differences in posterior alpha, N1 dipole or rACC theta across sessions. Test-retest reliability was .84 for alpha, .87 for N1 dipole, and .70 for theta rACC current density. The demonstration of good-to-excellent reliability for these measures provides a template for future EEG/ERP studies from multiple testing sites, and an important step for evaluating them as biomarkers for predicting treatment response.

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Section: Methodsmentioning

confidence: 99%

Demonstrating test‐retest reliability of electrophysiological measures for healthy adults in a multisite study of biomarkers of antidepressant treatment response

et al. 2016

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“…Of interest, the authors underlined the important role of the cerebellum in the pathogenesis of ADHD, which is in line with the conceptualization that the cerebellum is involved in higher order cognition, including executive function, through intimate reciprocal connections with frontostriatal regions (Leiner, Leiner, & Dow, 1989;McAlonan et al, 2007;Middleton & Strick, 1994). The posterior CC and its nearby cortical volumes (e.g., posterior cingulate=precuneus) share extensive connections throughout parietal and occipital cortices, and damage to these regions may be related to decreased volume of the posterior CC, which would be directly associated to decreases in numerous neuropsychological and integrative functions (Cannon, Crane, et al, 2011). These cortical regions and their functional and structural connectivity are a topic for future studies.…”

Section: Discussionmentioning

confidence: 96%