Abstract:Tumor-specific molecular targets and alternative therapeutic strategies for triple-negative breast cancer (TNBC) are urgently needed. The protease cathepsin D (cath-D) is a marker of poor prognosis in TNBC and a tumor-specific extracellular target for antibody-based therapy. The identification of cath-D substrates is essential for the mechanistic understanding of its role in TNBC and future therapeutic developments. Using degradomic analyses by TAILS, we discovered that the matricellular protein SPARC is a sub… Show more
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