A 73-Year-Old Woman Treated for Rheumatoid Arthritis with Lower Rectal Carcinoma Who Underwent Abdominoperineal Resection, Lateral Regional Lymph Node Resection, and Partial Hepatectomy by Hand-Assisted Laparoscopic Surgery (HALS): A Case Report

Tajima, Takayuki; Mukai, Masaya; Uda, Shuji; Izumi, Hideki; Yokoyama, Daiki; Hasegawa, Sayuri; Nomura, Eiji

doi:10.12659/ajcr.936106

Cited by 1 publication

(3 citation statements)

References 18 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At present, commonly used RA drug treatments mainly include non-steroidal anti-inflammatory drugs, glucocorticoids, disease-modifying antirheumatic drugs, biological products, and traditional Chinese herbal medicines. [26][27][28] Given that the pathogenesis of RA is still unclear, existing drugs cannot completely cure RA. [26][27][28] Our study establishes that expression of TTC4 mRNA in articular tissue of mice with RA was downregulated.…”

Section: Discussionmentioning

confidence: 99%

“…[26][27][28] Given that the pathogenesis of RA is still unclear, existing drugs cannot completely cure RA. [26][27][28] Our study establishes that expression of TTC4 mRNA in articular tissue of mice with RA was downregulated. Shang et al identified TTC4 as a positive regulator of Sendai virus-induced innate immunity.…”

Section: Discussionmentioning

confidence: 99%

“…In severe cases, it can cause various complications such as cardiovascular, lung, and bone. At present, commonly used RA drug treatments mainly include non‐steroidal anti‐inflammatory drugs, glucocorticoids, disease‐modifying antirheumatic drugs, biological products, and traditional Chinese herbal medicines 26–28 . Given that the pathogenesis of RA is still unclear, existing drugs cannot completely cure RA 26–28 .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

TTC4 inhibits NLRP3 inflammation in rheumatoid arthritis by HSP70

Lü

Xie

et al. 2023

Int J of Rheum Dis

View full text Add to dashboard Cite

ObjectiveThis experiment explored the function of TTC4 in rheumatoid arthritis inflammation and its possible mechanism.MethodsC57BL/6 mice were immunized intradermally with bovine type II collagen. Lipopolysaccharide induction was performed on RAW264.7 cells.ResultsThe mRNA expression of TTC4 in articular tissue of mice with rheumatoid arthritis was downregulated. Sh‐TTC4 virus increased arthritis score, morphological change score, paw edema, and spleen index, as well as alkaline phosphatase level in mice with rheumatoid arthritis. Sh‐TTC4 virus increased the levels of inflammatory factors and MDA, and decreased anti‐oxidant factors in articular tissue of mice with rheumatoid arthritis. TTC4 reduced inflammation and oxidative stress in an in vitro model. TTC4 regulated HSP70 in a rheumatoid arthritis model. The inhibition of HSP70 reduced the effects of sh‐TTC4 gene in mice with rheumatoid arthritis. METTL3 reduced the stability of the TTC4 gene.ConclusionIn this study, the TTC4 gene reduced oxidative response and inflammation in the rheumatoid arthritis model through the HSP70/NLRP3 pathway. Therefore, it can be concluded that TTC4 can be used as diagnosis and prognosis evaluation of rheumatoid arthritis.

show abstract