A 65-Year-Old Male With Classic Cardiac Sarcoidosis: Case Report and Review of the Literature

Abstract

Sarcoidosis is a systemic disease characterized by the formation of non-necrotizing granulomas, primarily involving the lungs and other organs such as the heart. The diagnosis of cardiac sarcoidosis can be difficult. The last set of diagnostic guidelines for diagnosis and treatment of cardiac sarcoidosis was published in 2019 by the Japanese Circulation Society (JCS).We describe a case of classic cardiac sarcoidosis and review the literature on clinical presentation, imaging, and management.

Synergistic Effects of Sulopenem in Combination with Cefuroxime or Durlobactam againstMycobacterium abscessus

“…The synergistic effects of dual β-lactams (imipenem and ceftaroline combination) (11), was achieved through the inhibition of multiple target proteins. Emerging clinical data further corroborate the effectiveness of dual β-lactam combinations (14–16). However, the co-administration of imipenem and cefoxitin, which are the sole two β-lactams recommended in the guidelines for Mab treatment, has undergone clinical trials with outcomes that lack clear evidence of efficacy (17).…”

“…Combination β-lactams was also found highly active in vitro in prior studies, this is exemplified by various combinations such as ceftaroline and imipenem (11), doripenem and cefdinir (12), ceftazidime and ceftaroline (28), imipenem and cefdinir, imipenem and cefoxitin (26), and sulopenem with CXM (29, 30), tebipenem, and CXM combined with amoxicillin (30) questioning the need for Bla Mab inhibition. Clinicians have utilized this approach in treating macrolide resistant Mab infections with reports of clinical success (14–16).…”

Soporte orgánico en la gestación de paciente con muerte cerebral. Reporte de caso

“…En la mayoría de los casos reportados en la literatura consultada la edad gestacional promedio al momento del parto fue de 29.5 semanas. Durante el soporte vital extendido, los pacientes desarrollaron varias complicaciones, incluyendo infección, inestabilidad hemodinámica, diabetes insípida, panhipopituitarismo, síndrome de dificultad respiratoria aguda y coagulación intravascular diseminada 4,5 .…”