A 61‐year‐old man with livedo reticularis

Hoganson, Deana D.; Weenig, Roger H.; Warrington, Kenneth J.

doi:10.1002/art.24199

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…There is one prior case report in the literature of a patient with NK cell leukemia who presented with generalized livedo reticularis and histopathologic findings that were consistent with polyarteritis nodosa [6]. The authors hypothesized that the specific expression pattern of killer cell immunoglobulin-like receptors (KIRs) that were demonstrated on flow cytometry, specifically the loss of inhibitory CD158a, CD158b, and CD158e, may lead to unopposed NK-cell activation and resulting vascular inflammation.…”

Section: Case Synopsismentioning

confidence: 99%

Livedo reticularis

Rose¹,

Saggar²,

Boyd³

et al. 2013

Dermatology Online Journal

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Livedo reticularis (LR) is a net-like, violaceous, hyperpigmented pattern on the skin that reflects an underlying change in cutaneous blood flow. The causes of LR are many and most commonly include connective tissue diseases, vasculitis, hypercoagulability, and embolic events. We describe a 49-year-old man who presented with painful LR and ulcers on the lower extremities as a manifestation of chronic natural killer cell leukemia (CNKL). There have been only a few cases previously reported in the literature. We report an additional case of a patient with both LR and CNKL and suggest a possible mechanism that explains this association.

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Section: Case Synopsismentioning

confidence: 99%