A 6-year longitudinal study: Are maternal depressive symptoms and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant treatment during pregnancy associated with everyday measures of executive function in young children?

Hutchison, Sarah M; Mâsse, Louise C.; Brain, Ursula; Oberlander, Tim F.

doi:10.1016/j.earlhumdev.2018.10.009

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…On the one hand, studies have reported higher levels of anxiety 16 and lower scores on motor-, social-emotional- and adaptive behavioral tests 17 after prenatal SSRI exposure. On the other hand, other studies found no association between in utero SSRI exposure and intellectual disability 18 , executive functioning 19 , and emotional or social problems 20 . Most of the evidence is obtained from studies in infants and children, likely due to the practical challenges of examining the effects of in utero exposure to SSRIs on behavioral outcomes in adulthood 21 .…”

Section: Introductionmentioning

confidence: 90%

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: a systematic review and meta-analyses of animal studies

Ramsteijn

Wijer

Rando

et al. 2019

Preprint

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AbstractIn the Western world, 2-5% of pregnant women use selective serotonin reuptake inhibitor (SSRI) antidepressants. There is no consensus on the potential long-term neurodevelopmental outcomes of early SSRI exposure. Our aim was to determine whether there is an overall effect of perinatal SSRI exposure in animals on a spectrum of behavioral domains. After a comprehensive database search in PubMed, PsycINFO, and Web of Science, we included 99 publications. We performed nine meta-analyses and two qualitative syntheses corresponding to different behavioral categories, aggregating data from thousands of animals. We found evidence for reduced activity and exploration behavior (standardized mean difference (SMD) −0.28 [-0.38, −0.18]), more passive stress coping (SMD −0.37 [-0.52, −0.23]), and less efficient sensory processing (SMD −0.37 [-0.69, −0.06]) in SSRI-versus vehicle-exposed animals. No differences were found for anxiety (p=0.06), social behavior, learning and memory, ingestive- and reward behavior, motoric behavior, or reflex and pain sensitivity. Exposure in the period equivalent to the human third trimester was associated with the strongest effects.HighlightsPerinatal SSRI exposure in rodents alters outcomes in three behavioral domains.It leads to reduced activity, passive stress coping, and weaker sensory processing.Females are understudied but seem to be less vulnerable than males.Early postnatal exposure in rodents leads to the largest effects on behavior.This is equivalent to the third trimester of pregnancy in humans.

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Section: Introductionmentioning

confidence: 90%

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: a systematic review and meta-analyses of animal studies

Ramsteijn

Wijer

Rando

et al. 2019

Preprint

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“…The secondary outcome measures cover the following domains—behavioural attention (inattention and hyperactivity), working memory, social cognition and numeracy—and have been included to assess whether far transfer occurs as a result of the intervention 27 36 37. The predictor measures cover the domains of sleep, intrinsic motivation, family relationships, mental health and social cognition (parent report) 15 17 38–43. Predictor measures were selected because they have been linked to cognitive development in children and may influence the efficacy of the intervention 38–43…”

Section: Methods and Analysismentioning

confidence: 99%

Training attention in children with acquired brain injury: a study protocol of a randomised controlled trial of the TALI attention training programme

et al. 2019

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IntroductionChildhood inattention has been linked with poor academic outcomes, and increased lifetime social, occupational and psychiatric morbidity. Children with an acquired brain injury (ABI) are particularly susceptible to attention deficits and may benefit from interventions aimed at enhancing attention. The primary objective of this study is to evaluate the short-term efficacy of the TALI Train programme, compared with a placebo, on the outcome of attention in children with ABI.Methods and analysisThe study is a parallel, double-blind, randomised controlled trial. Participants will consist of 80 children with a diagnosis of ABI aged 4–9 years 11 months. Participants will be randomly allocated to either (1) TALI Train (intervention group), an adaptive game-based attention training programme, or (2) a non-adaptive placebo programme (control group). Both programmes are delivered on a touchscreen tablet, and children complete five 20 min sessions per week for a 5-week period at home. Assessment of selective, sustained and executive attention (primary outcomes), and behavioural attention, working memory, social skills and mathematics ability (secondary outcomes) will occur at baseline, post-training, and at 3-month and 6-month follow-up to assess immediate and long-term efficacy of TALI Train compared with placebo. Assessments will be completed at the Royal Children’s Hospital in Melbourne, Australia. All assessments and analyses will be undertaken by researchers blinded to group membership. Latent growth curve modelling will be employed to examine primary and secondary outcomes.Ethics and disseminationEthics approval has been obtained from the Royal Children’s Hospital Human Research Ethics Committee (HREC) (38132) and the Monash University HREC (17446). Results will be disseminated through peer-reviewed journals, conference presentations, media outlets, the internet and various community/stakeholder activities.Trial registration numberACTRN12619000511134.

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“…Depression of the mother impacts the fetus, e.g., by the enhanced cortisol levels in the mother which also pass the placenta. There is strong evidence that increased stress levels of the mother may lead to neurological and behavioral changes in the child which persists at least into adolescence (e.g., [11]). In the contribution of Staal and Olivier (Chapter 2), a review is given of the consequences of depression during pregnancy.…”

Section: Side Effectsmentioning

confidence: 99%

Introductory Chapter: Antidepressants - Preclinical, Clinical and Translational Aspects

Olivier¹

2019

Antidepressants - Preclinical, Clinical and Translational Aspects

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A 6-year longitudinal study: Are maternal depressive symptoms and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant treatment during pregnancy associated with everyday measures of executive function in young children?

Cited by 21 publications

References 35 publications

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: a systematic review and meta-analyses of animal studies

Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: a systematic review and meta-analyses of animal studies

Training attention in children with acquired brain injury: a study protocol of a randomised controlled trial of the TALI attention training programme

Introductory Chapter: Antidepressants - Preclinical, Clinical and Translational Aspects

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