A 6-month randomized pilot study of black tea and cardiovascular risk factors

Mukamal, Kenneth J.; MacDermott, Kristen; Vinson, Joe A.; Oyama, Noriko; Manning, Warren J.; Mittleman, Murray A.

doi:10.1016/j.ahj.2007.07.008

Cited by 39 publications

(40 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Allocation concealment was adequate in two studies [19,22]. Three studies adopted appropriate method (e.g.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Therefore, 11 trials involved 411 adult participants were included in this metaanalysis. Six trials from 5 studies were conducted in healthy people [16,17,21,23,25] while the other five trials were performed in subjects with higher cardiovascular risk such as prediabetes or hypercholesterolemia [18e20, 22,24]. The sample size ranged from 15 to 77 with a median of 31.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The sample size ranged from 15 to 77 with a median of 31. Six trials lasted for 4 weeks [17,19e21,23,25], four trials lasted longer than 10 weeks [16,22,24] and the average duration was up to 8 weeks. Only two trials were conducted in East Asian countries [21,24] and the rest were mostly performed in America or Europe.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Only two trials were conducted in East Asian countries [21,24] and the rest were mostly performed in America or Europe. Black tea extract capsule was used in two trials [22,24] and the remaining adopted black tea beverages as the intervention treatment. Controlled background diet was adopted only in one trial [18].…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials

Zhao

Asimi

et al. 2015

Clinical Nutrition

View full text Add to dashboard Cite

“…Allocation concealment was adequate in two studies [19,22]. Three studies adopted appropriate method (e.g.…”

Section: Quality Assessmentmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials

Zhao

Asimi

et al. 2015

Clinical Nutrition

View full text Add to dashboard Cite

“…Widlansky et al (49) observed, in patients with coronary artery disease, an increase in plasma catechins concentration after 4 weeks of daily ingestion of 900 ml black tea without any effect on CRP. In diabetic subjects, CRP and IL-6, were unaffected by green tea (900 ml) administration (50) as were fibrinogen, TNFa, intercellular adhesion molecule and vascular cell adhesion molecule after 6 months of daily consumption of black tea in diabetic subjects (51) .…”

Section: Anti-inflammatory Properties Of Flavonoidsmentioning

confidence: 99%

Flavonoids as anti-inflammatory agents

2010

View full text Add to dashboard Cite

Epidemiological evidence suggests that a high intake of plant foods is associated with lower risk of chronic diseases. However, the mechanism of action and the components involved in this effect have not been identified clearly. In recent years, the scientific community has agreed to focus its attention on a class of secondary metabolites extensively present in a wide range of plant foods: the flavonoids, suggested as having different biological roles. The antiinflammatory actions of flavonoids in vitro or in cellular models involve the inhibition of the synthesis and activities of different pro-inflammatory mediators such as eicosanoids, cytokines, adhesion molecules and C-reactive protein. Molecular activities of flavonoids include inhibition of transcription factors such as NF-kB and activating protein-1 (AP-1), as well as activation of nuclear factor-erythroid 2-related factor 2 (Nrf2). However, the in vitro evidence might be somehow of limited impact due to the non-physiological concentrations utilized and to the fact that in vivo flavonoids are extensively metabolized to molecules with different chemical structures and activities compared with the ones originally present in the food. Human studies investigating the effect of flavonoids on markers of inflammation are insufficient, and are mainly focused on flavonoid-rich foods but not on pure molecules. Most of the studies lack assessment of flavonoid absorption or fail to associate an effect on inflammation with a change in circulating levels of flavonoids. Human trials with appropriate placebo and pure flavonoid molecules are needed to clarify if flavonoids represent ancillary ingredients or key molecules involved in the anti-inflammatory properties of plant foods.

show abstract