A 6‐Month Multi‐Center Evaluation of Adjunctive Tetracycline Fiber Therapy Used in Conjunction With Scaling and Root Planing in Maintenance Patients: Clinical Results

Abstract

The purpose of this study was to compare the efficacy of scaling and root planing (S and RP) alone versus tetracycline fiber therapy used adjunctively with S and RP in the treatment of localized recurrent periodontitis sites in maintenance patients. A total of 113 patients receiving regular supportive periodontal therapy (SPT) were treated with whole mouth S and RP. Two non-adjacent sites in separate quadrants were selected in each patient for monitoring based on criteria that the sites were 5 to 8 mm deep and had a history of bleeding on probing. The chosen sites were randomly assigned to one of the two treatment groups. Probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL) were measured at baseline and 1, 3, and 6 months. At 1, 3 and 6 months, adjunctive fiber therapy was significantly better in reducing PD (P < 0.05) and reducing BOP (P < 0.05) than S and RP alone. At 6 months, fiber therapy was significantly better in promoting clinical attachment gain (P < 0.05) than S and RP alone. Overall, these results indicate that fiber therapy significantly enhanced the effectiveness of S and RP in the management of localized recurrent periodontitis sites, in patients receiving regular supportive periodontal treatment.

Effect of Tetracycline Hydrochloride Fibers (Periocol-Tc) on The Level of P. Gingivalis in Chronic Generalized Periodontitis: Clinical & Microbiological Study

“…Manufactured by Eucare pharmaceuticals pvt LTD Chennai (6) . The percentage improvement in mean gingival index score in experimental and control groups from Similar findings were observed in the studies conducted by Newman MG et al, 1994 (14) and Chandrashekar KT and Sinha S, 2011 (15) . Microbial parameters were assessed by collection of plaque sample on 0 (baseline), 15 th and 45 th day for quantitative and qualitative analysis of Porphyromonas gingivalis, On comparing the colony forming units per ml from baseline to 15 th day, mean change of 169.150 with 't' value of t= 10.404 indicates reduction up to 65.9% and 213.200 with 't' value of t= 22.323 showed reduction up to 73.6% in experimental and control groups respectively, indicating no statistical difference among two groups.…”

A comparative evaluation of the clinical effects of systemic and local doxycycline in the treatment of chronic periodontitis

“…Many studies on clinical effects of both systemic and local tetracyclines have been performed. In some of these studies, tetracyclines made no statistically significant difference on probing depths and clinical attachment levels (10,11,(14)(15)(16)(17)(18)(19) while in others successful clinical results were obtained by tetracycline and minocycline treatments (20)(21)(22)(23)(24)(25)(26)(27)(28). These studies evaluated only systemic or local antibiotic treatments with or without mechanical periodontal treatment.…”

“…Oral Sci. 46, [25][26][27][28][29][30][31][32][33][34][35] 2004) Key Words: tetracycline; systemic doxycycline; local doxycycline; periodontal treatment; local drug delivery; chronic periodontitis. …”

Perioceutics in the management of Periodontal Disease

“…Study done by Newman et al on adjunctive tetracycline fiber therapy showed that fiber markedly improved the success of scaling and root planing in the treatment of localized recurrent periodontal cases and in supportive periodontal therapy. 19 For subgingival delivery, tetracycline impregnated fibres of 0.5mm in diameter made up of copolymer of ethylene vinyl acetate and tetracycline hydrochloride are used. It has been noted that a sustained high level of tetracycline averaging 1590 μg/ml delivering up to 25% of available tetracycline was observed following 10days post placement in gingival crevicular fluid.…”