A 6-Month Follow-Up Study of the Relation between Apolipoprotein E Gene Polymorphism and Major Adverse Cardiovascular Events in Patients with Acute Coronary Syndrome

Abstract

Objectives: This study aimed to investigate the relation between ApoE gene polymorphisms and major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) during a 6-month follow-up. Methods: From October 2016 to July 2017, 211 patients were admitted to a cardiology clinic with a diagnosis of ACS. Blood samples were obtained from all patients on the first day. The primary end point was a 6-month incidence of MACE. ApoE gene polymorphism was genotyped by real-time PCR using TaqMan® SNP Genotyping Assay. Results: The patients with the E4 allele were associated with higher low-density lipoprotein (LDL) cholesterol and total cholesterol (TC) levels compared with the patients without the E4 allele (p = 0001 and p = 0.001). The patients with the E4 allele were associated with a higher rate of MACE compared with the patients without the E4 allele (ApoE4 allele(+) 23.1% vs. ApoE4 allele(−) 9.3%; p = 0.03). Multivariable analysis suggested that E4 allele carriers showed an 85% risk increment of 6-month MACE (odds ratio 2.48, 95% confidence interval 2.37–5.95; p = 0.01). Conclusions: The trial shows that E4 allele carriers were correlated with not only higher LDL cholesterol and TC levels, but also with a higher incidence of MACE during a 6-month follow-up.

Association of Apolipoprotein E Gene Polymorphism with Lipid Profile in Patients with Acute Coronary Syndrome in Han Chinese: A Critical Review

“…Approximately, 200 hundred patients with myocardial infarction patients were followed for six months and demonstrated higher MACE in MI patient with ApoE gene isoform [13]. This study might have a new insight into the prognostic effect of ApoE genotype on coronary artery disease, specially, acute coronary syndrome.…”

“…It is consists of 3597 nucleotides. ApoE polymorphism has three different isoforms which are ApoE2, ApoE3 and ApoE4, synthesizing six various alleles such as E2/E2 (counted as E2 or E2 homozygous), E2/E3 (counted as E2 or E2 carrier), E3/E3 (counted as E3 and is the most common isoform amongst all three isoforms), E2/E4, E3/E4 (counted as E4 carrier), and E4/E4 (E4 homozygous) [13].…”