A 56-Year-Old Woman With Chronic Fatigue Syndrome, 1 Year Later

Delbanco, Thomas L.; Daley, Jennifer; Hartman, Erin E.

doi:10.1001/jama.280.4.372

Cited by 2 publications

(3 citation statements)

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“…Nortriptyline 60 mg/day demonstrated benefit for depressive symptoms and fatigue [as measured by the Beck Depression Inventory (BDI) and Chronic Fatigue Symptom Checklist] in a double-blind crossover study [37]. Additionally, case reports in numerous patients support the benefit of amitriptyline and doxepin (25 -50 mg at night) in CFS [38][39][40]. With regard to the treatment of fibromylagia with associated fatigue, there is a more comprehensive body of data supporting the utility of TCA.…”

Section: Tricyclic Antidepressantsmentioning

confidence: 97%

Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants

Pae

Marks

Patkar

et al. 2009

Expert Opinion on Pharmacotherapy

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Chronic fatigue syndrome (CFS) is characterized by chronic, medically unexplained fatigue associated with effort- and stress-intolerance, widespread pain, and impairment in sleep and concentration. Although this constellation of symptoms is highly prevalent in clinical practice, the pathophysiological mechanisms underlying CFS are poorly understood. Current evidence indicates similarities in symptomatology, and possibly etiology and pathogenesis, between CFS and depression. Additionally, there is significant overlap between CFS and the syndrome of fibromyalgia for which antidepressants have shown consistent efficacy. Data regarding antidepressant treatment of CFS is less copious and less uniformly positive, such that antidepressant use in CFS remains controversial. The current review aims to summarize available data related to antidepressants and other psychotropic agents in CFS to provide a platform for clinicians to make decisions in their treatment of this challenging syndrome. We identified relevant studies through a PubMed literature search with a combination of the following search terms: 'fatigue,' 'depression,' 'antidepressant,' 'etiology' (e.g., 'neurobiology,' 'neurotransmitter,' 'genetic'), 'diagnosis,' and 'treatment' (e.g., 'antidepressant' plus the specific name). In addition, studies were also identified via the reference sections of retrieved articles. The authors thoroughly reviewed major findings from the scanned literatures and eventually synthesized them, providing summary, interpretation, and future directions.

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Section: Tricyclic Antidepressantsmentioning

confidence: 97%

Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants

Pae

Marks

Patkar

et al. 2009

Expert Opinion on Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…1,2,[6][7][8][9] While there is stronger evidence for the efficacy of antidepressants in conditions such as fibromyalgia, antidepressants can also work to alleviate depression brought on by dealing with a chronic medical condition. 65 In a doubleblind crossover study, 66 60 mg/day of nortriptyline was shown to relieve depressive symptoms and fatigue (as measured by the Beck Depression Inventory and Chronic Fatigue Symptom Checklist). In addition, a case report 65 has also shown benefit following a…”

Section: Antidepressantsmentioning

confidence: 99%

“…65 In a doubleblind crossover study, 66 60 mg/day of nortriptyline was shown to relieve depressive symptoms and fatigue (as measured by the Beck Depression Inventory and Chronic Fatigue Symptom Checklist). In addition, a case report 65 has also shown benefit following a…”

Section: Antidepressantsmentioning

confidence: 99%

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review

Larrimore¹,

Ramnot²,

Jaghab³

et al. 2019

The Journal of the American Osteopathic Association

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Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overall lack of awareness within the medical community. As a result, patients are often frustrated by the difficulties in acquiring a diagnosis and from the overall lack of available treatments. In an effort to increase awareness, this review discusses disease pathophysiology, clinical presentation, and treatment options, while also highlighting the benefits of an osteopathic approach.

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A 56-Year-Old Woman With Chronic Fatigue Syndrome, 1 Year Later

Cited by 2 publications

References 1 publication

Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants

Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants

Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and the Emerging Osteopathic Approach: A Narrative Review

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