A 512×576 65-nm CMOS ISFET sensor for food safety screening with 123.8 mV/pH sensitivity and 0.01 pH resolution

Jiang, Yu; Liu, Xu; Dang, Tran Chien; Yan, Mei; Yu, Hao; Huang, Jui Chien; Hsieh, Cheng-Hsiang; Chen, Tung-Tsun

doi:10.1109/vlsit.2016.7573440

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…We observe that, in the low current regime, corresponding to the ISFET subthreshold region of operation, the resolution is much better than in the high current regime. The best (smallest) resolution is in good agreement with that of similar devices in the literature [ 12 , 14 , 41 , 42 , 43 , 44 , 45 ]. Table 3 compares the resolution of this work with works based on other ISFETs in the literature, using the same evaluation criteria.…”

Section: Resultssupporting

confidence: 88%

Sensitivity, Noise and Resolution in a BEOL-Modified Foundry-Made ISFET with Miniaturized Reference Electrode for Wearable Point-of-Care Applications

Bellando

Mele

Palestri

et al. 2021

Sensors

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Ion-sensitive field-effect transistors (ISFETs) form a high sensitivity and scalable class of sensors, compatible with advanced complementary metal-oxide semiconductor (CMOS) processes. Despite many previous demonstrations about their merits as low-power integrated sensors, very little is known about their noise characterization when being operated in a liquid gate configuration. The noise characteristics in various regimes of their operation are important to select the most suitable conditions for signal-to-noise ratio (SNR) and power consumption. This work reports systematic DC, transient, and noise characterizations and models of a back-end of line (BEOL)-modified foundry-made ISFET used as pH sensor. The aim is to determine the sensor sensitivity and resolution to pH changes and to calibrate numerical and lumped element models, capable of supporting the interpretation of the experimental findings. The experimental sensitivity is approximately 40 mV/pH with a normalized resolution of 5 mpH per µm2, in agreement with the literature state of the art. Differences in the drain current noise spectra between the ISFET and MOSFET configurations of the same device at low currents (weak inversion) suggest that the chemical noise produced by the random binding/unbinding of the H+ ions on the sensor surface is likely the dominant noise contribution in this regime. In contrast, at high currents (strong inversion), the two configurations provide similar drain noise levels suggesting that the noise originates in the underlying FET rather than in the sensing region.

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Section: Resultssupporting

confidence: 88%

Sensitivity, Noise and Resolution in a BEOL-Modified Foundry-Made ISFET with Miniaturized Reference Electrode for Wearable Point-of-Care Applications

Bellando

Mele

Palestri

et al. 2021

Sensors

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“…Recently, the development of optical sensors for various detection applications indicates their potential to be used in food safety [4][5][6]. The operating principle of optical sensors rely to the detection of refractive index of surrounding medium.…”

Section: Introductionmentioning

confidence: 99%

Real time detection of milk’s spoilage using Au/GO bend SMF sensor based on localized surface plasmon resonance effect

Mukhtar¹,

Kamarolzaman²

2020

JMES

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Potential of hybrid gold nanoparticles/Graphene Oxide (Au/GO) coated single mode fiber (SMF) sensor by exploiting localized surface plasmon resonance (LSPR) effect for detection of spoiled milk is studied. Various diameters of SMF’s cladding are prepared ranging from its original size, d=0.1250mm to d=0.1215mm. A mechanical polishing technique using sandpaper is applied to etch the cladding area in which results the SMF with diameter less than 0.1250mm. Hybrid layers of Au/GO are deposited onto the SMF via drop-casting technique by varies the number of layers of GO between one to five layers, meanwhile Au nanoparticles are kept constant at one layer. To generate LSPR, light with excitation wavelength of 1310nm and 1550nm are transmitted at the first end of Au/GO coated SMF resulting in strong scattering and extinction spectra. The fiber is bend about 8cm in diameter to produce evanescent waves around it. To investigate the sensitivity of sensor in detecting milk’s spoilage condition, the Au/GO bend SMF sensor is immersed into the milk’s solution which has been exposed to the environment for 24 hours, 48 hours and 72 hours. The maximum optical power response, ΔP%=6.85% is obtained when the one layer of Au/GO coated bend SMF had been immersed into the milk solution with exposure time of 24 hours. The values of ΔP% decrease about 3.50% and 2.00% respectively with the increment of exposure time at 48 hours and 72 hours. These results indicate the sensing ability of our proposed sensor to detect different levels of spoiled milk as the exposure time increased. The output of this study validates the main role of LSPR effect in enhancing the sensitivity of Au/GO bend SMF sensor for real time detection of milk’s spoilage.

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“…In order to solve the above issues, we proposed, for the first time, a pH-to-timeto-voltage converter (pH-TVC) (our works from [83,89,90]), where a sub-threshold ISFET is employed, as shown in Fig. 3.7(b).…”

Section: Ph-to-time-to-voltage Convertermentioning

confidence: 99%

“…In order to study and characterize ISFET properties, the 512×576 pixel array is divided into several sub-arrays with source-follower or pH-TVC readout circuits, with different ISFET chemical sensing areas or transistor sizes, and so on (our works from [83,89,90]).…”

Section: ×576 Cmos Isfet Sensormentioning

confidence: 99%

Electrochemical and optical CMOS sensors design for biochemical detection

Jiang¹

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The contributions of the co-authors are as follows:• Prof Yu provided the initial ideal and edited the manuscript drafts.• Prof. Zhang and Prof. Feng revised the manuscript drafts.• I prepared the manuscript drafts, designed the ISFET pixel array with the pH-TVC readout circuit, worked in the full chip integration, built the testing system, and performed all the measurements, experiments, and data processing.

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A 512×576 65-nm CMOS ISFET sensor for food safety screening with 123.8 mV/pH sensitivity and 0.01 pH resolution

Cited by 8 publications

References 3 publications

Sensitivity, Noise and Resolution in a BEOL-Modified Foundry-Made ISFET with Miniaturized Reference Electrode for Wearable Point-of-Care Applications

Sensitivity, Noise and Resolution in a BEOL-Modified Foundry-Made ISFET with Miniaturized Reference Electrode for Wearable Point-of-Care Applications

Real time detection of milk’s spoilage using Au/GO bend SMF sensor based on localized surface plasmon resonance effect

Electrochemical and optical CMOS sensors design for biochemical detection

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