A 50-Year-Old Patient with Guillain–Barré Syndrome after COVID-19: A Case Report

Chmiela, Tomasz; Rzepka, Michalina; Krzystanek, Ewa; Gorzkowska, Agnieszka

doi:10.3390/medicina57080775

Cited by 4 publications

(3 citation statements)

References 25 publications

(46 reference statements)

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“…In another case, we emphasized Lyme disease, which clinically presented as PSPS and showed a favorable clinical response to specific antimicrobial therapy [ 16 , 17 ]. Given the cases cited and taking into consideration the spectrum of immune-induced reactions already described in the context of COVID-19 infection, we hypothesize a possible cross-reactivity between COVID-19 antigen and some hosts antigens closely linked to the inhibitory neurotransmitter GABA, either directly, or by intermediary hosts proteins which interfere with GABA metabolism or receptor complex [ 20 ]. This hypothesis is in need of further exploration, but we would like to raise awareness of this specific clinical entity, as we believe it may be more common than it is currently perceived.…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Still Surprising Us—A Rare Movement Disorder Induced by Infection

Sîrbu¹,

Popescu²,

Ștefan

et al. 2022

Brain Sciences

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Background: Many neurological manifestations are part of COVID-19 infections, including movement disorders, but a clinical picture closely resembling stiff-person syndrome has not yet been described. Case presentation: We report a case of a stiff-person-like syndrome in the context of COVID-19 infection. A 79-year-old woman, with no prior history of diseases, presented global reversible stiffness associated with SARS-CoV-2 infection. We aim to shed light on several particularities regarding this clinical picture and its evolution in close relationship with the infectious disease progression, with full regression of symptoms and signs once the infectious process ceased. The impairment of speech and motility caused the wrong diagnosis of stroke in the Emergency Room. In addition, we would also like to emphasize the concomitant rhabdomyolysis, closely linked to the grade of muscle rigidity. Conclusions: We would like to raise awareness regarding this clinical setting and its association with SARS-COV-2 infection, to aid in its future recognition and management. To our knowledge, this is the first case of a stiff-person-like syndrome to be described in association with COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Still Surprising Us—A Rare Movement Disorder Induced by Infection

Sîrbu¹,

Popescu²,

Ștefan

et al. 2022

Brain Sciences

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“…Throughout medical literature, a link between COVID-19 infection and GBS emergence has been observed. 3 4 5 6 7 …”

Section: Introductionmentioning

confidence: 99%

Guillain–Barré Syndrome After COVID-19 Infection in Korea: A Case Series

Ryoo,

Son,

Kim

et al. 2024

J Korean Med Sci

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Guillain–Barré syndrome (GBS) is an autoimmune-driven condition characterized by acute polyneuropathy, often emerging as a sequel to prior infections or vaccinations. This study presents the first reported cases of GBS emerging after the full recovery from coronavirus disease 2019 (COVID-19) infection in Korea. Despite experiencing mild acute COVID-19 symptoms, these patients faced substantial weakness attributed to GBS, significantly affecting their daily lives. The timely administration of intravenous immunoglobulin treatment halted the progression of symptoms, underscoring the critical importance of early intervention. These cases highlight the potential for neurological complications associated with COVID-19 and underscore the necessity for continuous monitoring and timely medical care.

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“…Multidisciplinary medical care and immunotherapy, such as intravenous immunoglobulin (IVIG) and plasma exchange (PE), are optimal treatments in GBS [ 2 ]. Most GBS patients get a full recovery, while some patients developed chronic disabilities and 3–10% of cases die during the acute phase [ 4 ]. The novel outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, named as coronavirus disease 2019 (COVID-19), usually manifests with respiratory symptoms, and neurological harm, such as GBS.…”

Section: Introductionmentioning

confidence: 99%

Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?

et al. 2023

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Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory polyradiculoneuropathy, which commonly leads to a very high level of neurological disability. Especially, after the global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the causation between GBS and SARS-CoV-2 infection and the coronavirus disease 2019 (COVID-19) vaccination have aroused widespread concern. In the review, we analyzed the impacts of SARS-CoV-2 infection and COVID-19 vaccination on GBS globally, aiming to further understand the characteristics of GBS associated with COVID-19. Based on the electrophysiological data, patients suffering from GBS related to COVID-19 manifested as an acute inflammatory demyelinating polyneuropathy (AIDP). Moreover, we summarized the current findings, which may evidence GBS linking to SARS-CoV-2 infection and COVID-19 vaccination, and discussed the underlying mechanisms whether and how the SARS-CoV-2 virus and COVID-19 vaccination can induce GBS and its variants.

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A 50-Year-Old Patient with Guillain–Barré Syndrome after COVID-19: A Case Report

Cited by 4 publications

References 25 publications

COVID-19 Still Surprising Us—A Rare Movement Disorder Induced by Infection

COVID-19 Still Surprising Us—A Rare Movement Disorder Induced by Infection

Guillain–Barré Syndrome After COVID-19 Infection in Korea: A Case Series

Is there a causal nexus between COVID-19 infection, COVID-19 vaccination, and Guillain-Barré syndrome?

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