2004
DOI: 10.1016/s0190-9622(03)03323-1
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A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis*1

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“…Our findings, although significant, were not as impressive as those observed in the psoriasis vulgaris group (75% vs 53% reduction). Carlin et al (16) have suggested that a PASI score reduction of 50% can be considered a clinically significant endpoint in the assessment of psoriasis. We chose to treat this group less intensively with a once weekly dosing regimen in order to evaluate whether this schedule was effective, as this schedule provides the greatest convenience to the patient and increases therapy compliance.…”
Section: Discussionmentioning
confidence: 99%
“…Our findings, although significant, were not as impressive as those observed in the psoriasis vulgaris group (75% vs 53% reduction). Carlin et al (16) have suggested that a PASI score reduction of 50% can be considered a clinically significant endpoint in the assessment of psoriasis. We chose to treat this group less intensively with a once weekly dosing regimen in order to evaluate whether this schedule was effective, as this schedule provides the greatest convenience to the patient and increases therapy compliance.…”
Section: Discussionmentioning
confidence: 99%