A 5-year follow-up on antibody response after diphtheria and tetanus vaccination in hemodialysis patients

Krüger, Sabine; Müller‐Steinhardt, Michael; Kirchner, Holger; Kreft, Burkhard

doi:10.1053/ajkd.2001.29223

Cited by 57 publications

(51 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20] We also found a lower protection rate against diphtheria in both hemodialysis and control groups, as compared with Karakus et al [23] Previously, the Kruger study showed that during a five-year period, antibody persistence against the tetanus toxoid is better than that against the diphtheria toxoid. [2] It is noteworthy to mention that due to our results, not only is the rate of protection against diphtheria lower than the rate of protection against tetanus in both the control and HD patients, but also, unlike the serum anti-tetanus IgG level (p = 0.008), there was no meaningful difference in antidiphtheria IgG between the control and the patients groups (p = 0.48). Thus, in general, our population seems to be more susceptible to diphtheria than tetanus.…”

Section: Discussioncontrasting

confidence: 48%

“…[1] This immunodeficiency status is associated with decreased immunoglobulin production, diminished interleukin-2 secretion by T lymphocytes, impaired macrophage function, and the co-stimulatory properties of antigen presenting cells. [2,3] Thus, hemodialysis patients represent a special population because of the above-mentioned immunodeficiency status and unique exposure, which makes it imperative that we take advantage of all potential mechanisms to prevent infectious complications in patients with renal disease. [4] This deficient immune system is related to many factors, including duration of hemodialysis [5] or zinc deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…As a result, several studies have focused on the protection of these patients by vaccination. [2,8] In spite of the widespread vaccination programs against diphtheria and tetanus in the general population of Iran and other countries, [12,13] we still face cases of diphtheria and tetanus in human societies [14,15] as well as chronic kidney disease (CKD) patients, in whom we have previously shown a significant difference in the antitetanus protection rate (52.8%) compared to that of healthy individuals (74.3%). [5] In addition, it has been demonstrated that protection against diphtheria and the immune response to Td vaccine in hemodialysis (HD) patients is poor (i.e., a seroconversion rate of 37%).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

2009

View full text Add to dashboard Cite

Patients with end stage renal disease suffer from a high incidence of infectious diseases believed to be related to their impaired immune system. To determine the antitetanus and antidiphtheria IgG antibody levels in Iranian hemodialysis patients with end stage renal disease, as well as its association with sex, age, hemoglobin, zinc serum level, serum albumin, duration of dialysis, number of dialysis per week, dialysis adequacy, erythropoietin or iron supplements such as venofer, body mass index (BMI), and underlying renal disorder, we conducted a crosssectional study on a total of 112 hemodialysis patients with end stage renal disorder (60 male, 52 female ) and 36 healthy individuals in the control group (14 male, 22 female). The patients and the control group received no antitetanus or antidiphtheria vaccine or immunoglobulin in the year prior to the investigation. The serum antitetanus and antidiphtheria IgG antibody levels were measured using the ELISA method. We found out that only 16% of our hemodialysis patients were immune to diphtheria (19% of the control group), and this rate for tetanus was 24% (48.2% in the healthy control). Except for the hemodialysis duration, none of the mentioned factors seemed to affect immunity. We conclude that in our study, the level of the antitetanus IgG antibody (unlike the antidiphtheria IgG antibody level) is significantly different among the hemodialysis patients, the chronic hemodialysis patients, and the control group.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

2009

View full text Add to dashboard Cite

show abstract

“…A few studies were done on immunization against tetanus in patients with chronic renal failure [28][29][30][31][32][33] . Tetanus protected individuals in the patients group were significantly less than tetanus protected individuals in the control group (34.6 Vs 63.30%) (p = 0.011).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Tetanus Immunity in Haemodialysis Patients

Jahromi¹,

Raoofi²,

Sarikhani³

et al. 2009

American J. of Immunology

View full text Add to dashboard Cite

Problem statement: The incidence of infectious diseases is increased in patients with chronic renal failure. Chronic renal failure severely influences the immune functions of the host. Approach: To evaluate the antitetanus immunity level in southern Iranian patients with end stage renal disease undergoing hemodialysis and to find its association with sex, age, blood hemoglobin and serum albumin, duration of dialysis. This cross sectional study was carried out on a total of 52 patients, who were on hemodialysis and 52 age and sex matched healthy individuals with without any underlying renal disease as a control group. Individuals in the both groups receiving antitetanus toxoid vaccine or immunoglubins a year prior to the study were excluded. The serum antitetanus IgG antibody levels were measured by an ELISA method. Results: Tetanus protected individuals in the patients and the control groups were 34.6 and 63.30% respectively. Of the evaluating factors just hemodialysis duration found to affect on tetanus immunity. Conclusion: Tetanus protected individuals in the patients group were significantly less than tetanus protected individuals in the control group (p = 0.011). Hemodialysis duration has significant effect on antitetanus immunity level.

show abstract

“…Alle erhobenen Daten deuten zwar auf eine kaum beeinträch-tigte Primärantwort hin, deutlich verkürzt dürfte aber die Immunitätsdauer und dies insbesondere betreffend das Diphtherie-Antigen sein [43]. Die Indikation steht außer Streit.…”

Section: Chronische Nierenerkrankungen/dialysepatientenunclassified

Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Wiedermann

Sitte

Burgmann

et al. 2016

Wien Klin Wochenschr

View full text Add to dashboard Cite

A 5-year follow-up on antibody response after diphtheria and tetanus vaccination in hemodialysis patients

Cited by 57 publications

References 18 publications

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

A Study on the Protection of Hemodialysis Patients Against Diphtheria and Tetanus

Evaluation of Anti-Tetanus Immunity in Haemodialysis Patients

Impfungen bei Immundefekten/Immunsuppression – Expertenstatement und Empfehlungen

Contact Info

Product

Resources

About