A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain
Jing-Ping Lin,
Alexis Brake,
Maxime Donadieu
et al.
Abstract:Single-time-point histopathological studies on postmortem multiple sclerosis (MS) tissue fail to capture lesion evolution dynamics, posing challenges for therapy development targeting development and repair of focal inflammatory demyelination. To close this gap, we studied experimental autoimmune encephalitis (EAE) in the common marmoset, the most faithful animal model of these processes. Using MRI-informed RNA profiling, we analyzed ∼600,000 single-nucleus and ∼55,000 spatial transcriptomes, comparing them ag… Show more
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