A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing

Lu, Jiawei; Chen, Yi; Ding, Mengxian; Fan, Xiaokun; Hu, Jiawei; Chen, Yihua; Li, Jie; Li, Zhihan; Liu, Wenyong

doi:10.1016/j.carbpol.2021.118871

Cited by 143 publications

(56 citation statements)

References 43 publications

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“…Thus, bacterial infection of wounds should be detected and treated as soon as possible. In recent years, many SAMN-based antibacterial strategies have been demonstrated for surgical wound treatment. ,,,, …”

Section: Emerging Applications Of Samnsmentioning

confidence: 99%

“…, wound treatment, oral disease treatment), antibacterial materials are often incorporated into hydrogels, fabrics, etc . to create removable ointments or dressings that can effectively conform to the treated area. , For medical device surface anti-biofilm activity, e.g. , food and pharmaceutical manufacturing equipment and medical implants, antibacterial materials are generally processed into the form of coating that adheres to solid surfaces. , In water disinfection, antibacterial materials are often incorporated in meshes ( e.g.…”

Section: Emerging Applications Of Samnsmentioning

confidence: 99%

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Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

et al. 2022

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Bacterial infections remain the leading cause of death worldwide today. The emergence of antibiotic resistance has urged the development of alternative antibacterial technologies to complement or replace traditional antibiotic treatments. In this regard, metal nanomaterials have attracted great attention for their controllable antibacterial functions that are less prone to resistance. This review discusses a particular family of stimuli-activable metal-bearing nanomaterials (denoted as SAMNs) and the associated on-demand antibacterial strategies. The various SAMN-enabled antibacterial strategies stem from basic light and magnet activation, with the addition of bacterial microenvironment responsiveness and/or bacteriatargeting selectivity and therefore offer higher spatiotemporal controllability. The discussion focuses on nanomaterial design principles, antibacterial mechanisms, and antibacterial performance, as well as emerging applications that desire on-demand and selective activation (i.e., medical antibacterial treatments, surface anti-biofilm, water disinfection, and wearable antibacterial materials). The review concludes with the authors' perspectives on the challenges and future directions for developing industrial translatable next-generation antibacterial strategies.

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Section: Emerging Applications Of Samnsmentioning

confidence: 99%

Section: Emerging Applications Of Samnsmentioning

confidence: 99%

Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

et al. 2022

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“…NPs can be integrated with various hydrogel materials such as alginate, gelatin, gelatin methacrylate, and chitosan [ 106 , 127 , 128 ]. There are several approaches to integrating NPs into hydrogels, including hydrogel formation on a preformed nanoparticle suspension or gelation of the hydrogel followed by physical incorporation of the NPs within it [ 129 , 130 ]. As well as the incorporation of collagen nanofibers with metallic NPs, in vivo studies already demonstrate that the healing rate of wounds treated with collagen nanofibers and metallic NPs was accelerated compared to simple collagen nanofibers, with accelerated re-epithelialization, collagen production and better wound contraction [ 131 , 132 ].…”

Section: Perspectivesmentioning

confidence: 99%

The Use of Metallic Nanoparticles in Wound Healing: New Perspectives

Mendes

Thirupathi

Corrêa

et al. 2022

IJMS

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Chronic wounds represent a challenge for the health area, as they directly impact patients’ quality of life and represent a threat to public health and the global economy due to their high cost of treatment. Alternative strategies must be developed for cost-effective and targeted treatment. In this scenario, the emerging field of nanobiotechnology may provide an alternative platform to develop new therapeutic agents for the chronic wound healing process. This manuscript aims to demonstrate that the application of metallic nanoparticles (gold, silver, copper, and zinc oxide) opened a new chapter in the treatment of wounds, as they have different properties such as drug delivery, antimicrobial activity, and healing acceleration. Furthermore, metallic nanoparticles (NPs) produced through green synthesis ensure less toxicity in biological tissues, and greater safety of applicability, other than adding the effects of NPs with those of extracts.

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“…Hydrogels are a three-dimensional crosslinked polymeric matrix which can maintain its structure while preserving large amounts of water [9,10]. With the capability to mimic the properties of extracellular matrices, cells, and soft tissues, hydrogels are widely used as biomedical implants and tissue substitutes [11,12].…”

Section: Introductionmentioning

confidence: 99%

Injectable PTHF-based thermogelling polyurethane implants for long-term intraocular application

et al. 2022

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Background Hydrogels show great potential to be used for intraocular applications due to their high-water content and similarity to the native vitreous. Injectable thermosensitive hydrogels through a small-bore needle can be used as a delivery system for drugs or a tamponading substitute to treat posterior eye diseases with clear clinical potential. However, none of the currently available thermosensitive hydrogels can provide intraocular support for up to 3 months or more. Method In this study, an injectable polytetrahydrofuran (PTHF)-based thermosensitive hydrogel was synthesized by polyurethane reaction. We examined the injectability, rheological properties, microstructure, cytotoxicity, and in vivo compatibility and stability of the hydrogels in rabbit eyes. Results We found that the PTHF block type and PTHF component ratio could modulate thermogelation properties of the polyurethane polymers. The PTHF-based hydrogel implants retained normal retinal structure and function. Incorporating bioinert PTHF generated highly biocompatible and more stable thermogels in the vitreous cavity, with gel networks and the presence of polymer still observed after 3 months when other thermogels would have been completely cleared. Moreover, despite lacking hydrolytically cleavable linkages, the polymers could be most naturally removed from the native vitreous by bio-erosion without additional surgical interventions. Conclusion Our findings suggest the potential of incorporating hydrophobic bioinert blocks to enhance the in vivo stability of supramolecularly associated hydrogels for long-term intraocular applications. Graphical Abstract

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A 4arm-PEG macromolecule crosslinked chitosan hydrogels as antibacterial wound dressing

Cited by 143 publications

References 43 publications

Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

Stimuli-Activable Metal-Bearing Nanomaterials and Precise On-Demand Antibacterial Strategies

The Use of Metallic Nanoparticles in Wound Healing: New Perspectives

Injectable PTHF-based thermogelling polyurethane implants for long-term intraocular application

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