A 40-year-old Woman with Hypercalcemia Crisis Caused by Bone Metastasis in Stage IV Breast Cancer

Abstract

Breast cancer is still global burden especially for woman with 2.3 million cases every year dan 15% mortality among cancer diseases. In developing countries, most of the cases are diagnosed at terminal stage when metastasis already found. Bone metastasis is the highest among other metastasis sites such as: lung, liver and brain. Bone metastasis will cause hypercalcemia and bone pain as complications. Both will gradually decrease patient’s quality of life. Comprehensive and holistic management for these complications will reduce deterioration and hopefully increase patient’s quality of life even they were at terminal stage. We describe a 40-year-old woman who got hypercalcemia crisis. Hypercalcemia usually manifest as a consequence of other diseases. Epidemiologically, majority come from metastasis, but can be other diseases, such as multiple myeloma. Interestingly, during medical investigation through her medical history, and physical examination, and laboratory examinations, we conclude that her hypercalcemia crisis was caused by bone metastasis from breast cancer.

Parathyroid Carcinoma Mimicking Multiple Myeloma: A Tale of Refractory Hypercalcemia

“…On the contrary, hyperparathyroidism (primary and tertiary) causes refractory hypercalcemia with elevated intact PTH and normal to increased 24-hours urine calcium. [2][3][4] Primary hyperparathyroidism (PHPT) is a parathyroid gland abnormality causing inappropriately high and unsuppressed PTH. The symptoms of PHPT are related to PTH hyperactivity, such as hypercalcemia, bone diseases (fracture and pain), and kidney stone formation.…”

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“…In 2020, breast cancer stood out as the most frequently identified cancer type, securing fifth place among the primary contributors to global mortality [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15].…”

Interleukin-6 serum levels in metastatic breast cancer and non-metastatic breast cancer

“…In Indonesia, a total of 17,792 new breast cancer cases were reported. (Hyuna et al, 2021;Dewi et al, 2020;Hadisuwarno et al, 2021;Dewi TK, 2018) Despite many recent advances in the detection and treatment of breast cancer, the development of metastasis remains a significant problem and the main driver of mortality. Indeed, patients with localized breast cancer have a five-year survival rate of about 98%.…”