A 3D multifunctional bi-layer scaffold to regulate stem cell behaviors and promote osteochondral regeneration

Zhang, Po; Chen, Jialin; Sun, Yuzhi; Cao, Zhicheng; Zhang, Yanan; Mo, Qingyun; Yao, Qingqiang; Zhang, Wei

doi:10.1039/d2tb02203f

Cited by 13 publications

(16 citation statements)

References 63 publications

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“…[2] Despite the great progress in the shape-controlled synthesis of LHP NCs, only a few reports have demonstrated to date the synthesis of ASnX 3 counterparts (Table 1). [2,54,55,[65][66][67] A wide range of approaches (such as the hot injection (HI), ligand-assisted reprecipitation (LARP), hydrothermal, ultrasonication, and emulsion synthesis, etc.) [2] have been employed for the preparation of LHP NCs.…”

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

“…Among all, HI and LARP are the most commonly adapted approaches for the synthesis of THP NCs. [2,46,54,55,[65][66][67] The THP NCs can be broadly classified into three categories: i) ASnX 3 (A = Cs, FA, MA; X = Cl, Br, I) type 3D HPs, ii) A ' 2 SnX 4 (A' = organic ligands; X = Cl, Br, I) type 2D layered perovskites and iii) A 2 SnX 6 (A = Cs, FA, MA; X = Cl, Br, I) type perovskites. In this section, we summarize the main achievements in these directions, point out the key issues that remain unresolved, and present our perspectives on future research directions.…”

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

“…Nevertheless, it should be noted that the shape-controlled synthesis of stable colloidal THP NCs is still in an early stage compared to that of LHP NCs in terms of the rational control over the reactivity of reactants used for the synthesis, understanding of reaction mechanisms and reproducibility of the synthesis. [56,65] In this regard, Gahlot et al attempted to obtain stable, tunable, and monodisperse CsSnI 3 NCs exhibiting well-defined excitonic peaks by an optimized synthetic route. [56] It was found that the presence of excess SnI 2 precursor and the substoichiometric Sn:ligand ratio are the keys to obtaining stable CsSnI 3 NCs.…”

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

“…They identified that the active intermediate complexes, polymeric alkanoate iodides that form via the reaction of the iodide source with oligomers present in the tin (II) carboxylates, play a role in governing the reactivity of the tin-iodide precursor, resulting in the variation in the size, size uniformity, and PLQY of CsSnI 3 NCs. [65] The understanding of the reaction mechanism in the synthesis of THP NCs would not only lead to improved synthesis strategies, but also might offer guidelines for fabricating high-quality polycrystalline films that can be used for optoelectronic devices such as LEDs and photovoltaics, considering the similar defect formation mechanisms in both LHP NCs and polycrystalline films.…”

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

See 3 more Smart Citations

Lead‐Free Halide Perovskite Materials and Optoelectronic Devices: Progress and Prospective

López‐Fernández,

Valli,

Wang

et al. 2023

Adv Funct Materials

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Halide perovskites, in the form of thin films and colloidal nanocrystals, have recently taken semiconductor optoelectronics research by storm, and have emerged as promising candidates for high‐performance solar cells, light‐emitting diodes (LEDs), lasers, photodetectors, and radiation detectors. The impressive optical and optoelectronic properties, along with the rapid increase in efficiencies of solar cells and LEDs, have greatly attracted researchers across many disciplines. However, most advances made so far in terms of preparation (colloidal nanocrystals and thin films), and the devices with highest efficiencies are based on Pb‐based halide perovskites, which have raised concerns over their commercialization due to the toxicity of Pb. This has triggered the search for lower‐toxicity Pb‐free halide perovskites and has led to significant progress in the last few years. In this roadmap review, researchers of different expertise have joined together to summarize the latest progress, outstanding challenges, and future directions of Pb‐free halide perovskite thin films and nanocrystals, regarding their synthesis, optical spectroscopy, and optoelectronic devices, to guide the researchers currently working in this area as well as those that will join the field in the future.

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Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

Section: Synthesis Of Tin Halide Perovskite Ncsmentioning

confidence: 99%

See 2 more Smart Citations

Lead‐Free Halide Perovskite Materials and Optoelectronic Devices: Progress and Prospective

López‐Fernández,

Valli,

Wang

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Moreover, Zhang et al 23 decorated chitosan/gelatin-tannic acid (CS/GE-TA) on the porous tape suture with anti-inflammatory and antibacterial performances for tendon healing. Due to its antioxidant and anti-inflammatory bioactivities, along with its reliable modification and coating capabilities, 24 TA has sparked considerable interest in the field of biomedicine, making it highly promising for a wide range of applications. Decellularized extracellular matrix (dECM) scaffolds have been extensively applied in tendon repair 25 because of their biomimetic environment and appropriate physicochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Tannic Acid-Modified Decellularized Tendon Scaffold with Antioxidant and Anti-Inflammatory Activities for Tendon Regeneration

Zhao,

Luo,

Cui

et al. 2024

ACS Appl. Mater. Interfaces

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Tendon regeneration is greatly influenced by the oxidant and the inflammatory microenvironment. Persistent inflammation during the tendon repair can cause matrix degradation, tendon adhesion, and excessive accumulation of reactive oxygen species (ROS), while excessive ROS affect extracellular matrix remodeling and tendon integration. Herein, we used tannic acid (TA) to modify a decellularized tendon slice (DTS) to fabricate a functional scaffold (DTS-TA) with antioxidant and anti-inflammatory properties for tendon repair. The characterizations and cytocompatibility of the scaffolds were examined in vitro. The antioxidant and anti-inflammatory activities of the scaffold were evaluated in vitro and further studied in vivo using a subcutaneous implantation model. It was found that the modified DTS combined with TA via hydrogen bonds and covalent bonds, and the hydrophilicity, thermal stability, biodegradability, and mechanical characteristics of the scaffold were significantly improved. Afterward, the results demonstrated that DTS-TA could effectively reduce inflammation by increasing the M2/M1 macrophage ratio and interleukin-4 (IL-4) expression, decreasing the secretion of interleukin-6 (IL-6) and interleukin-1β (IL-1β), as well as scavenging excessive ROS in vitro and in vivo. In summary, DTS modified with TA provides a potential versatile scaffold for tendon regeneration.

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Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable

Wu,

Wang,

Wang

et al. 2024

Advanced Materials

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Over the decades, the management of osteochondral lesions remains a significant yet unmet medical challenge without curative solutions to date. Owing to the complex nature of osteochondral units with multi‐tissues and multicellularity, and inherently divergent cellular turnover capacities, current clinical practices often fall short of robust and satisfactory repair efficacy. Alternative strategies, particularly tissue engineering assisted with biomaterial scaffolds, achieve considerable advances, with the emerging pursuit of a more cost‐effective approach of in situ osteochondral regeneration, as evolving toward cell‐free modalities. By leveraging endogenous cell sources and innate regenerative potential facilitated with instructive scaffolds, promising results are anticipated and being evidenced. Accordingly, a paradigm shift is occurring in scaffold development, from biodegradable and biocompatible to bioadaptable in spatiotemporal control. Hence, this review summarizes the ongoing progress in deploying bioadaptable criteria for scaffold‐based engineering in endogenous osteochondral repair, with emphases on precise control over the scaffolding material, degradation, structure and biomechanics, and surface and biointerfacial characteristics, alongside their distinguished impact on the outcomes. Future outlooks of a highlight on advanced, frontier materials, technologies, and tools tailoring precision medicine and smart healthcare are provided, which potentially paves the path toward the ultimate goal of complete osteochondral regeneration with function restoration.

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A 3D multifunctional bi-layer scaffold to regulate stem cell behaviors and promote osteochondral regeneration

Abstract: Osteochondral defect (OCD) regeneration remains a great challenge. Recently, multilayer scaffolds simulating native osteochondral structures have aroused broad interest in osteochondral tissue engineering. Here, we developed a 3D multifunctional bi-layer...

Cited by 13 publications

References 63 publications

Lead‐Free Halide Perovskite Materials and Optoelectronic Devices: Progress and Prospective

Lead‐Free Halide Perovskite Materials and Optoelectronic Devices: Progress and Prospective

Tannic Acid-Modified Decellularized Tendon Scaffold with Antioxidant and Anti-Inflammatory Activities for Tendon Regeneration

Advancing Scaffold‐Assisted Modality for In Situ Osteochondral Regeneration: A Shift From Biodegradable to Bioadaptable

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